Treatment of severe generalized chronic periodontitis in a patient with Behçet’s disease: A case report

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Behçet’s disease is a systemic disorder of unknown etiology. It involves multiple organ systems and is characterized by recurring episodes of oral ulcers as well as ocular, genital, and skin lesions. Oral ulcers can affect tooth brushing and impair proper oral hygiene. As a result, a dental biofilm accumulates, and the condition of the teeth and periodontal tissue deteriorates. The aim of this case report is to highlight the efficacy of periodontal treatment for patients with Behçet’s disease. A 51-year-old man with Behçet’s disease presented with generalized severe periodontitis. After basic treatment of the periodontal tissues, periodontal surgery was performed at several sites with bony defects. However, the patient developed severe stomatitis in the oral mucosa and gingiva after periodontal surgery. Administration of the antimicrobial agent cefdinir had little effect on recovery; however, subsequent administration of sitafloxacin resulted in significant improvement of the stomatitis. This case demonstrates that periodontal therapy is very useful for alleviating the oral signs and symptoms of Behçet’s disease. Systemic antibiotic treatment with sitafloxacin (but not cefdinir) and mechanical debridement were effective in preventing the recurrence of aphthous ulcer outbreaks after periodontal surgery.

Original languageEnglish
Pages (from-to)2037-2045
Number of pages9
JournalJournal of International Medical Research
Issue number5
Publication statusPublished - 2018 May 1


  • Behçet’s disease
  • oral aphthous ulcers
  • outbreak of stomatitis
  • periodontal disease
  • periodontal surgery
  • sitafloxacin

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Biochemistry, medical


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