True moving bed chromatography: Solid-liquid multi-stage counter-current extraction

Hideyuki Nishizawa, Kayoko Tahara, Shinobu Miyamori, Yoko Motegi, Tomoko Shoji, Yoshihiro Abe

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)


An apparatus for solid-liquid multi-stage dual-flow counter-current extraction was created for performance of true moving bed chromatography. Using the 12-vessel apparatus, continuous adsorptive separation of methyl- and propyl-4-hydroxybenzoate was accomplished using octadecyl-silica gel as the solid phase, and a mixture of water-1-propanol (8:2) as the liquid phase. From a 1:1 mixture of methyl and propyl esters, methyl ester was extracted into the liquid phase at a purity of 98.83% and propyl ester was recovered from the solid phase by desorption with the same liquid phase to 95.89% purity. Copyright (C) 1999 Elsevier Science B.V.

Original languageEnglish
Pages (from-to)61-69
Number of pages9
JournalJournal of Chromatography A
Issue number1
Publication statusPublished - 1999 Jul 16


  • Counter-current extraction
  • Extraction methods
  • Hydroxybenzoate
  • Instrumentation
  • Preparative chromatography
  • True moving bed chromatography

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Organic Chemistry


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