Trypanocidal constituents of Dracocephalum komarovi

Nahoko Uchiyama, Fumiyuki Kiuchi, Michiho Ito, Gisho Honda, Yoshio Takeda, Olimjon K. Khodzhimatov, Ozodbek A. Ashurmetov

Research output: Contribution to journalArticlepeer-review

27 Citations (Scopus)


Trypanocidal constituents of Dracocephalum komarovi were investigated. Under guidance of the in vitro trypanocidal activity against epimastigotes of Trypanosoma cruzi, the causative agent of Chagas' disease, two new diterpenes, dracocequinones A (1) and B (2), and two known triterpene acids, ursonic acid and ursolic acid, were isolated as trypanocidal constituents, in addition to previously reported diterpenes, cyclocoulterone (4), komaroviquinone (5), dracocephalone A (6) and komarovispirone (7). Furthermore a new diterpene, komarovinone A (3), was isolated, together with four known terpenes. Among these compounds, komaroviquinone (5) showed the most potent activity with minimum lethal concentration of 0.4 μM. Structure elucidation of the new diterpenes 1-3 was described.

Original languageEnglish
Pages (from-to)4355-4359
Number of pages5
Issue number18
Publication statusPublished - 2006 May 1
Externally publishedYes


  • Diterpene
  • Dracocephalum komarovi
  • Trypanocidal activity
  • Trypanosoma cruzi

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry


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