Trypanocidal terpenoids from Laurus nobilis L.

Nahoko Uchiyama, Keiji Matsunaga, Fumiyuki Kiuchi, Gisho Honda, Akiko Tsubouchi, Junko Nakajima-Shimada, Takashi Aoki

Research output: Contribution to journalArticlepeer-review

45 Citations (Scopus)


Trypanocidal constituents of dried leaves of Laurus nobilis L. (Lauraceae) were examined. Activity-guided fractionation of the methanol extract resulted in the isolation of two guaianolides, dehydrocostus lactone (1) and zaluzanin D (2), and a new p-menthane hydroperoxide, (1R,4S)-1-hydroperoxy-p-menth-2-en-8-ol acetate (3). The minimum lethal concentrations of these compounds against epimastigotes of Trypanosoma cruzi were 6.3, 2.5, and 1.4 μM, respectively.

Original languageEnglish
Pages (from-to)1514-1516
Number of pages3
JournalChemical and Pharmaceutical Bulletin
Issue number11
Publication statusPublished - 2002 Nov
Externally publishedYes


  • Guaianolide
  • Lauraceae
  • Laurus nobilis
  • Trypanosoma cruzi
  • p-menthane hydroperoxide

ASJC Scopus subject areas

  • Chemistry(all)
  • Drug Discovery


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