Trypanocidal terpenoids from Laurus nobilis L.

Nahoko Uchiyama; Keiji Matsunaga; Fumiyuki Kiuchi; Gisho Honda; Akiko Tsubouchi; Junko Nakajima-Shimada; Takashi Aoki

doi:10.1248/cpb.50.1514

Trypanocidal terpenoids from Laurus nobilis L.

Nahoko Uchiyama, Keiji Matsunaga, Fumiyuki Kiuchi, Gisho Honda, Akiko Tsubouchi, Junko Nakajima-Shimada, Takashi Aoki

Research output: Contribution to journal › Article › peer-review

45 Citations (Scopus)

Abstract

Trypanocidal constituents of dried leaves of Laurus nobilis L. (Lauraceae) were examined. Activity-guided fractionation of the methanol extract resulted in the isolation of two guaianolides, dehydrocostus lactone (1) and zaluzanin D (2), and a new p-menthane hydroperoxide, (1R,4S)-1-hydroperoxy-p-menth-2-en-8-ol acetate (3). The minimum lethal concentrations of these compounds against epimastigotes of Trypanosoma cruzi were 6.3, 2.5, and 1.4 μM, respectively.

Original language	English
Pages (from-to)	1514-1516
Number of pages	3
Journal	Chemical and Pharmaceutical Bulletin
Volume	50
Issue number	11
DOIs	https://doi.org/10.1248/cpb.50.1514
Publication status	Published - 2002 Nov
Externally published	Yes

Keywords

Guaianolide
Lauraceae
Laurus nobilis
Trypanosoma cruzi
p-menthane hydroperoxide

ASJC Scopus subject areas

Chemistry(all)
Drug Discovery

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10.1248/cpb.50.1514

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title = "Trypanocidal terpenoids from Laurus nobilis L.",

abstract = "Trypanocidal constituents of dried leaves of Laurus nobilis L. (Lauraceae) were examined. Activity-guided fractionation of the methanol extract resulted in the isolation of two guaianolides, dehydrocostus lactone (1) and zaluzanin D (2), and a new p-menthane hydroperoxide, (1R,4S)-1-hydroperoxy-p-menth-2-en-8-ol acetate (3). The minimum lethal concentrations of these compounds against epimastigotes of Trypanosoma cruzi were 6.3, 2.5, and 1.4 μM, respectively.",

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language = "English",

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T1 - Trypanocidal terpenoids from Laurus nobilis L.

AU - Uchiyama, Nahoko

AU - Matsunaga, Keiji

AU - Kiuchi, Fumiyuki

AU - Honda, Gisho

AU - Tsubouchi, Akiko

AU - Nakajima-Shimada, Junko

AU - Aoki, Takashi

PY - 2002/11

Y1 - 2002/11

N2 - Trypanocidal constituents of dried leaves of Laurus nobilis L. (Lauraceae) were examined. Activity-guided fractionation of the methanol extract resulted in the isolation of two guaianolides, dehydrocostus lactone (1) and zaluzanin D (2), and a new p-menthane hydroperoxide, (1R,4S)-1-hydroperoxy-p-menth-2-en-8-ol acetate (3). The minimum lethal concentrations of these compounds against epimastigotes of Trypanosoma cruzi were 6.3, 2.5, and 1.4 μM, respectively.

AB - Trypanocidal constituents of dried leaves of Laurus nobilis L. (Lauraceae) were examined. Activity-guided fractionation of the methanol extract resulted in the isolation of two guaianolides, dehydrocostus lactone (1) and zaluzanin D (2), and a new p-menthane hydroperoxide, (1R,4S)-1-hydroperoxy-p-menth-2-en-8-ol acetate (3). The minimum lethal concentrations of these compounds against epimastigotes of Trypanosoma cruzi were 6.3, 2.5, and 1.4 μM, respectively.

KW - Guaianolide

KW - Lauraceae

KW - Laurus nobilis

KW - Trypanosoma cruzi

KW - p-menthane hydroperoxide

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Trypanocidal terpenoids from Laurus nobilis L.

Abstract

Keywords

ASJC Scopus subject areas

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