TY - JOUR
T1 - TFH-IgA responses keep microbiota in check
AU - Honda, Kenya
N1 - Publisher Copyright:
© 2015 Elsevier Inc.
PY - 2015/2/11
Y1 - 2015/2/11
N2 - In this issue of Cell Host & Microbe, Kubinak et al. (2015) demonstrate that gut microbiota-mediated signaling through MyD88 in CD4+ T cells induces their differentiation into T follicular helper (TFH) cells that promote affinity-matured microbiota antigen-specific immunoglobulin A (IgA) responses. These TFH-driven IgA responses are essential for maintaining gut bacterial diversity and a healthy microbiota.
AB - In this issue of Cell Host & Microbe, Kubinak et al. (2015) demonstrate that gut microbiota-mediated signaling through MyD88 in CD4+ T cells induces their differentiation into T follicular helper (TFH) cells that promote affinity-matured microbiota antigen-specific immunoglobulin A (IgA) responses. These TFH-driven IgA responses are essential for maintaining gut bacterial diversity and a healthy microbiota.
UR - http://www.scopus.com/inward/record.url?scp=84922907573&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84922907573&partnerID=8YFLogxK
U2 - 10.1016/j.chom.2015.01.009
DO - 10.1016/j.chom.2015.01.009
M3 - Short survey
C2 - 25674979
AN - SCOPUS:84922907573
SN - 1931-3128
VL - 17
SP - 144
EP - 146
JO - Cell Host and Microbe
JF - Cell Host and Microbe
IS - 2
ER -