TFH-IgA responses keep microbiota in check

Research output: Contribution to journalShort surveypeer-review

7 Citations (Scopus)


In this issue of Cell Host & Microbe, Kubinak et al. (2015) demonstrate that gut microbiota-mediated signaling through MyD88 in CD4+ T cells induces their differentiation into T follicular helper (TFH) cells that promote affinity-matured microbiota antigen-specific immunoglobulin A (IgA) responses. These TFH-driven IgA responses are essential for maintaining gut bacterial diversity and a healthy microbiota.

Original languageEnglish
Pages (from-to)144-146
Number of pages3
JournalCell Host and Microbe
Issue number2
Publication statusPublished - 2015 Feb 11

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Virology


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