TFH-IgA responses keep microbiota in check

Kenya Honda

doi:10.1016/j.chom.2015.01.009

T_FH-IgA responses keep microbiota in check

Kenya Honda

Department of Microbiology and Immunology

Research output: Contribution to journal › Short survey › peer-review

7 Citations (Scopus)

Abstract

In this issue of Cell Host & Microbe, Kubinak et al. (2015) demonstrate that gut microbiota-mediated signaling through MyD88 in CD4⁺ T cells induces their differentiation into T follicular helper (T_FH) cells that promote affinity-matured microbiota antigen-specific immunoglobulin A (IgA) responses. These T_FH-driven IgA responses are essential for maintaining gut bacterial diversity and a healthy microbiota.

Original language	English
Pages (from-to)	144-146
Number of pages	3
Journal	Cell Host and Microbe
Volume	17
Issue number	2
DOIs	https://doi.org/10.1016/j.chom.2015.01.009
Publication status	Published - 2015 Feb 11

ASJC Scopus subject areas

Parasitology
Microbiology
Virology

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10.1016/j.chom.2015.01.009

Cite this

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title = "TFH-IgA responses keep microbiota in check",

abstract = "In this issue of Cell Host \& Microbe, Kubinak et al. (2015) demonstrate that gut microbiota-mediated signaling through MyD88 in CD4+ T cells induces their differentiation into T follicular helper (TFH) cells that promote affinity-matured microbiota antigen-specific immunoglobulin A (IgA) responses. These TFH-driven IgA responses are essential for maintaining gut bacterial diversity and a healthy microbiota.",

author = "Kenya Honda",

note = "Publisher Copyright: {\textcopyright} 2015 Elsevier Inc.",

year = "2015",

month = feb,

day = "11",

doi = "10.1016/j.chom.2015.01.009",

language = "English",

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T1 - TFH-IgA responses keep microbiota in check

AU - Honda, Kenya

PY - 2015/2/11

Y1 - 2015/2/11

N2 - In this issue of Cell Host & Microbe, Kubinak et al. (2015) demonstrate that gut microbiota-mediated signaling through MyD88 in CD4+ T cells induces their differentiation into T follicular helper (TFH) cells that promote affinity-matured microbiota antigen-specific immunoglobulin A (IgA) responses. These TFH-driven IgA responses are essential for maintaining gut bacterial diversity and a healthy microbiota.

AB - In this issue of Cell Host & Microbe, Kubinak et al. (2015) demonstrate that gut microbiota-mediated signaling through MyD88 in CD4+ T cells induces their differentiation into T follicular helper (TFH) cells that promote affinity-matured microbiota antigen-specific immunoglobulin A (IgA) responses. These TFH-driven IgA responses are essential for maintaining gut bacterial diversity and a healthy microbiota.

UR - https://www.scopus.com/pages/publications/84922907573

UR - https://www.scopus.com/pages/publications/84922907573#tab=citedBy

U2 - 10.1016/j.chom.2015.01.009

DO - 10.1016/j.chom.2015.01.009

M3 - Short survey

C2 - 25674979

AN - SCOPUS:84922907573

SN - 1931-3128

VL - 17

SP - 144

EP - 146

JO - Cell Host and Microbe

JF - Cell Host and Microbe

IS - 2

ER -

T_FH-IgA responses keep microbiota in check

Abstract

ASJC Scopus subject areas

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