@inproceedings{cb4c514fd7214d3a97c20cc1692bf760,
title = "Tublogenesis of endothelial cells in core-shell hydrogel microfibers",
abstract = "This paper describes tube formation of endothelial cells in collagen/alginate core-shell hydrogel microfiber. We found that encapsulated MS1 (mouse pancreatic endothelial cell line) and HUVEC (human umbilical vein endothelial cell) spontaneously create tube-like monolayer cell structures along the axial direction of the fiber at meter-length scale. Because the produced endothelial tubes are free-standing and handleable in a culture medium with the support of the alginate shell, our endothelial cell fibers would be a fundamental tissue unit for constructing three-dimensional (3D) macroscopic tissues with vascular network and for analyzing cellular behaviors (ex. vasculogenesis or angiogenesis) under intercellular/chemical/mechanical/fluidic interactions.",
keywords = "Cell encapsulation, Endothelial cell, Hydrogel, Microfiber, Vascular",
author = "Hiroaki Onoe and Shoji Takeuchi",
year = "2012",
month = jan,
day = "1",
language = "English",
isbn = "9780979806452",
series = "Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012",
publisher = "Chemical and Biological Microsystems Society",
pages = "1069--1071",
booktitle = "Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012",
note = "16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012 ; Conference date: 28-10-2012 Through 01-11-2012",
}