Tumor angiogenesis and dynamic CT in lung adenocarcinoma: Radiologic-Pathologic correlation

Ukihide Tateishi, Hiroshi Nishihara, Satoshi Watanabe, Toshiaki Morikawa, Kazuhiro Abe, Kazuo Miyasaka

Research output: Contribution to journalArticlepeer-review

105 Citations (Scopus)


Purpose: The purpose of this work was to evaluate the correlation of tumor angiogenesis and dynamic CT in lung adenocarcinoma. Method: Thirty-five consecutive patients with lung adenocarcinoma underwent dynamic chest CT. Maximum attenuation of dynamic CT was compared with microvessel densities (MVDs) and vascular endothelial growth factor (VEGF) expression by immunohistochemistry. Results: The mean peak attenuation (APA) of lung adenocarcinoma correlated with MVD (r = 0.689, p < 0.0001). VEGF positiveness of lung adenocarcinoma was 63%. There was a significant difference in APA between VEGF-positive and -negative lung adenocarcinomas (39.9 ± 3.9 and 24.3 ± 2.3; p < 0.05). The mean MVDs of VEGF-positive adenocarcinomas were significantly higher than those of negative ones (82.5 ± 5.9 and 49.2 ± 7.1; p < 0.05). The mean APA of VEGF-positive lung adenocarcinomas correlated positively with MVD (r = 0.707, p < 0.0001). Conclusion: The APA value of dynamic CT reflects MVD in lung adenocarcinoma. The APA value of dynamic CT might be an index for VEGF-related tumor angiogenesis.

Original languageEnglish
Pages (from-to)23-27
Number of pages5
JournalJournal of Computer Assisted Tomography
Issue number1
Publication statusPublished - 2001
Externally publishedYes


  • Computed tomography
  • Lungs, adenocarcinoma
  • Lungs, cancer
  • Vascular endothelial growth factor

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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