Tumor-identification method for predicting recurrence of early-stage lung adenocarcinoma using digital pathology images by machine learning

Hideharu Hattori, Shingo Sakashita, Masahiro Tsuboi, Genichiro Ishii, Toshiyuki Tanaka

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


Lung cancer is one of the cancers with the highest morbidity and mortality in the world. Recurrence often occurs even after complete resection of early-stage lung cancer, and prediction of recurrence after resection is clinically important. However, the pathological characteristics of the recurrence of pathological stage IB lung adenocarcinoma (LAIB) have not yet been elucidated. Therefore, the problem is what type of histological image of lung adenocarcinoma recurs, and it is important to examine the histological image of recurrence. We attempted to predict recurrence of early lung adenocarcinoma after resection on the basis of digital pathological images of hematoxylin and eosin-stained specimens and machine learning applying a convolutional neural network. We constructed a model that extracts the features of two-color spaces and a switching model that automatically switches between our extraction model and one that extracts the features of one-color space for each image. We then developed a tumor-identification method for predicting the presence or absence of LAIB recurrence using these models. We conducted an experiment involving 55 patients with LAIB who underwent surgical resection to evaluate the proposed method. The proposed method determined LAIB recurrence with an accuracy of 84.8%. The use of digital pathology and machine learning can be used for highly accurate prediction of LAIB recurrence after surgical resection. The proposed method has the potential for objective postoperative follow-up observation.

Original languageEnglish
Article number100175
JournalJournal of Pathology Informatics
Publication statusPublished - 2023 Jan


  • Convolutional neural network
  • H&E staining
  • Lung adenocarcinoma
  • Pathological image
  • Tumor tissue

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Health Informatics
  • Computer Science Applications


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