Tumor suppression by stromal TIMPs

Masayuki Shimoda, Hartland W. Jackson, Rama Khokha

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)


The tumor stroma has the capacity to drive cancer progression, although the mechanisms governing these effects are incompletely understood. Recently, we reported that deletion of tissue inhibitor of metalloproteinases (Timps) in fibroblasts unleashes the function of cancer-associated fibroblasts and identifies a novel mode of stromal–tumor communication that activates key oncogenic pathways invoving Notch and ras homolog gene family, member A (RhoA) via stromal exosomes.

Original languageEnglish
Article numbere975082
JournalMolecular and Cellular Oncology
Issue number3
Publication statusPublished - 2016 May 3


  • ADAM10
  • CAF
  • Notch
  • RhoA
  • TIMP
  • complete Timp deficiency
  • exosomes

ASJC Scopus subject areas

  • Molecular Medicine
  • Cancer Research


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