Tumor suppressor candidate 5 (TUSC5) is expressed in brown adipocytes

Hisashi Koide, Takahisa Shibata, Nobuko Yamada, Toshiyuki Asaki, Toshitaka Nagao, Tomohiko Yoshida, Yoshihiko Noguchi, Tomoaki Tanaka, Yasushi Saito, Ichiro Tatsuno

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)


Rat brain endothelial cell derived gene-1 (BEC-1) had considerable homology with tumor suppressor candidate 5 (TUSC5). TUSC5 was expressed abundantly, and its mRNA was inhibited by cold exposure in rat brown adipose tissue (BAT). In the present study, we investigated its regulatory mechanism using primary cultured rat brown preadipocytes (RBPA) and Zucker lean rats (ZL). We found that: (1) TUSC5 mRNA began to increase in a manner similar to C/EBP-α, PPAR-γ, and adiponectin during differentiation in RBPA; (2) neither β3-adrenoceptor agonist BRL 37344 nor dexamethasone affected TUSC5 mRNA in RBPA; (3) propranolol did not block the decrease of TUSC5 mRNA by cold exposure in ZL; (4) BRL 37344 did not influence TUSC5 mRNA in ZL; and (5) dexamethasone inhibited TUSC5 mRNA in a dose-dependent manner similar to UCP-1 in ZL. These data suggested that TUSC5 is involved in the differentiation, and its expression is regulated independently of the β-adrenergic pathway in BAT.

Original languageEnglish
Pages (from-to)139-145
Number of pages7
JournalBiochemical and Biophysical Research Communications
Issue number1
Publication statusPublished - 2007 Aug 17
Externally publishedYes


  • Adipocyte
  • BEC-1
  • Brown adipose tissue
  • Obese
  • TUSC5

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology


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