Two cases of "fulminant" type 1 diabetes suggesting involvement of autoimmunity

Yoshinori Nakagawa A, Akira Shimada, Yoichi Oikawa, Jun Ichiro Irie, Toshkatsu Shigihara, Kazuhiro Tsumura, Shosaku Narumi, Takao Saruta

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)


Recently, a novel subtype of type 1 diabetes, so-called fulminant type 1 diabetes, has been proposed. One of the characteristics of this subtype is the absence of detectable "islet-associated" autoantibody, so it was originally proposed as being "nonautoimmune-mediated"; however, it has not yet been concluded whether autoimmunity is involved. We have previously shown that serum interferon-inducible protein-10 and glutamic acid decarboxylase-reactive CD4+ interferon-γ-producing cells in the peripheral blood are good markers for T cell-mediated autoimmunity in type 1 diabetes. Here, we report two cases of fulminant type 1 diabetes in which these markers were detected and in which the involvement of islet-associated autoimmunity is suggested.

Original languageEnglish
Pages (from-to)359-361
Number of pages3
JournalAnnals of the New York Academy of Sciences
Publication statusPublished - 2003


  • Fulminant type 1 diabetes mellitus
  • Glutamic acid decarboxylase (GAD)
  • Interferon-inducible protein-10 (IP-10)

ASJC Scopus subject areas

  • General Neuroscience
  • General Biochemistry,Genetics and Molecular Biology
  • History and Philosophy of Science


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