TY - JOUR
T1 - Two new terpenes isolated from dictyostelium cellular slime molds
AU - Sasaki, Hitomi
AU - Kubohara, Yuzuru
AU - Ishigaki, Hirotaka
AU - Takahashi, Katsunori
AU - Eguchi, Hiromi
AU - Sugawara, Akihiro
AU - Oshima, Yoshiteru
AU - Kikuchi, Haruhisa
N1 - Funding Information:
Funding: This work was funded in part by the Grants-in-Aid for Scientific Research (no. 16H03279 and 19H02837) from the Ministry of Education, Culture, Sports, Science and Technology (MEXT), Japan; the Platform Project for Supporting in Drug Discovery and Life Science Research (Basis for Supporting Innovative Drug Discovery and Life Science Research (BINDS)) from AMED (no. P18am0101100); the Takeda Science Foundation; Suzuken Memorial Foundation; the Uehara Memorial Foundation; and Tokyo Biochemical Research Foundation.
Publisher Copyright:
© 2020 by the authors.
PY - 2020/6
Y1 - 2020/6
N2 - We report a protoilludane-type sesquiterpene, mucoroidiol, and a geranylated bicyclogermacranol, firmibasiol, isolated from Dictyostelium cellular slime molds. The methanol extracts of the fruiting bodies of cellular slime molds were separated by chromatographic methods to give these compounds. Their structures have been established by several spectral means. Mucoroidiol and firmibasiol are the first examples of more modified and oxidized terpenoids isolated from cellular slime molds. Mucoroidiol showed moderate osteoclast-differentiation inhibitory activity despite demonstrating very weak cell-proliferation inhibitory activity. Therefore, cellular slime molds produce considerably diverse secondary metabolites, and they are promising sources of new natural product chemistry.
AB - We report a protoilludane-type sesquiterpene, mucoroidiol, and a geranylated bicyclogermacranol, firmibasiol, isolated from Dictyostelium cellular slime molds. The methanol extracts of the fruiting bodies of cellular slime molds were separated by chromatographic methods to give these compounds. Their structures have been established by several spectral means. Mucoroidiol and firmibasiol are the first examples of more modified and oxidized terpenoids isolated from cellular slime molds. Mucoroidiol showed moderate osteoclast-differentiation inhibitory activity despite demonstrating very weak cell-proliferation inhibitory activity. Therefore, cellular slime molds produce considerably diverse secondary metabolites, and they are promising sources of new natural product chemistry.
KW - Cellular slime molds
KW - Dictyostelid
KW - Natural products
KW - Terpenoids
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U2 - 10.3390/molecules25122895
DO - 10.3390/molecules25122895
M3 - Article
C2 - 32585998
AN - SCOPUS:85087141416
SN - 1420-3049
VL - 25
JO - Molecules
JF - Molecules
IS - 12
M1 - 25122895
ER -