Two new terpenes isolated from dictyostelium cellular slime molds

Hitomi Sasaki; Yuzuru Kubohara; Hirotaka Ishigaki; Katsunori Takahashi; Hiromi Eguchi; Akihiro Sugawara; Yoshiteru Oshima; Haruhisa Kikuchi

doi:10.3390/molecules25122895

Two new terpenes isolated from dictyostelium cellular slime molds

Hitomi Sasaki, Yuzuru Kubohara, Hirotaka Ishigaki, Katsunori Takahashi, Hiromi Eguchi, Akihiro Sugawara, Yoshiteru Oshima, Haruhisa Kikuchi

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

We report a protoilludane-type sesquiterpene, mucoroidiol, and a geranylated bicyclogermacranol, firmibasiol, isolated from Dictyostelium cellular slime molds. The methanol extracts of the fruiting bodies of cellular slime molds were separated by chromatographic methods to give these compounds. Their structures have been established by several spectral means. Mucoroidiol and firmibasiol are the first examples of more modified and oxidized terpenoids isolated from cellular slime molds. Mucoroidiol showed moderate osteoclast-differentiation inhibitory activity despite demonstrating very weak cell-proliferation inhibitory activity. Therefore, cellular slime molds produce considerably diverse secondary metabolites, and they are promising sources of new natural product chemistry.

Original language	English
Article number	25122895
Journal	Molecules
Volume	25
Issue number	12
DOIs	https://doi.org/10.3390/molecules25122895
Publication status	Published - 2020 Jun
Externally published	Yes

Keywords

Cellular slime molds
Dictyostelid
Natural products
Terpenoids

ASJC Scopus subject areas

Analytical Chemistry
Chemistry (miscellaneous)
Molecular Medicine
Pharmaceutical Science
Drug Discovery
Physical and Theoretical Chemistry
Organic Chemistry

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10.3390/molecules25122895

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title = "Two new terpenes isolated from dictyostelium cellular slime molds",

abstract = "We report a protoilludane-type sesquiterpene, mucoroidiol, and a geranylated bicyclogermacranol, firmibasiol, isolated from Dictyostelium cellular slime molds. The methanol extracts of the fruiting bodies of cellular slime molds were separated by chromatographic methods to give these compounds. Their structures have been established by several spectral means. Mucoroidiol and firmibasiol are the first examples of more modified and oxidized terpenoids isolated from cellular slime molds. Mucoroidiol showed moderate osteoclast-differentiation inhibitory activity despite demonstrating very weak cell-proliferation inhibitory activity. Therefore, cellular slime molds produce considerably diverse secondary metabolites, and they are promising sources of new natural product chemistry.",

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AU - Sasaki, Hitomi

AU - Kubohara, Yuzuru

AU - Ishigaki, Hirotaka

AU - Takahashi, Katsunori

AU - Eguchi, Hiromi

AU - Sugawara, Akihiro

AU - Oshima, Yoshiteru

AU - Kikuchi, Haruhisa

PY - 2020/6

Y1 - 2020/6

N2 - We report a protoilludane-type sesquiterpene, mucoroidiol, and a geranylated bicyclogermacranol, firmibasiol, isolated from Dictyostelium cellular slime molds. The methanol extracts of the fruiting bodies of cellular slime molds were separated by chromatographic methods to give these compounds. Their structures have been established by several spectral means. Mucoroidiol and firmibasiol are the first examples of more modified and oxidized terpenoids isolated from cellular slime molds. Mucoroidiol showed moderate osteoclast-differentiation inhibitory activity despite demonstrating very weak cell-proliferation inhibitory activity. Therefore, cellular slime molds produce considerably diverse secondary metabolites, and they are promising sources of new natural product chemistry.

AB - We report a protoilludane-type sesquiterpene, mucoroidiol, and a geranylated bicyclogermacranol, firmibasiol, isolated from Dictyostelium cellular slime molds. The methanol extracts of the fruiting bodies of cellular slime molds were separated by chromatographic methods to give these compounds. Their structures have been established by several spectral means. Mucoroidiol and firmibasiol are the first examples of more modified and oxidized terpenoids isolated from cellular slime molds. Mucoroidiol showed moderate osteoclast-differentiation inhibitory activity despite demonstrating very weak cell-proliferation inhibitory activity. Therefore, cellular slime molds produce considerably diverse secondary metabolites, and they are promising sources of new natural product chemistry.

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KW - Dictyostelid

KW - Natural products

KW - Terpenoids

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Two new terpenes isolated from dictyostelium cellular slime molds

Abstract

Keywords

ASJC Scopus subject areas

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