Tyrosine phosphorylated proteins in synovial cells of rheumatoid arthritis

Tsutomu Takeuchi, Tohru Abe

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)


Two of the key events in the pathogenesis of rheumatoid arthritis are the synovial cell proliferation and lymphocyte infiltration into the synovium. The resulting synovitis is longlasting and leads to destructive arthritis, which is a hallmark of rheumatoid arthritis. Accumulating evidence suggests that one of the key biochemical events in the altered cell function of RA is phosphorylation of the tyrosine residues of proteins. In this paper we review the cellular components participating in the chronic inflammation of RA joints. We present the results of analyzing tyrosine phosphorylated proteins of synovial cells from RA patients and discuss a possible pathogenic role of non-receptor tyrosine kinase in RA.

Original languageEnglish
Pages (from-to)365-382
Number of pages18
JournalInternational Reviews of Immunology
Issue number5-6
Publication statusPublished - 1998
Externally publishedYes


  • Adhesion molecules
  • FAK
  • Integrins
  • Signal transduction
  • Tyrosine kinase

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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