Ultrasound-Induced New Cellular Mechanism Involved in Drug Resistance

Mariame A. Hassan, Yukihiro Furusawa, Masami Minemura, Natalya Rapoport, Toshiro Sugiyama, Takashi Kondo

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)


The acoustic effects in a biological milieu offer several scenarios for the reversal of multidrug resistance. In this study, we have observed higher sensitivity of doxorubicin-resistant uterine sarcoma MES-SA/DX5 cells to ultrasound exposure compared to its parent counterpart MES-SA cells; however, the results showed that the acoustic irradiation was genotoxic and could promote neotic division in exposed cells that was more pronounced in the resistant variant. The neotic progeny, imaged microscopically 24 hr post sonication, could contribute in modulating the final cell survival when an apoptotic dose of doxorubicin was combined with ultrasound applied either simultaneously or sequentially in dual-treatment protocols. Depending on the time and order of application of ultrasound and doxorubicin in combination treatments, there was either desensitization of the parent cells or sensitization of the resistant cells to doxorubicin action.

Original languageEnglish
Article numbere48291
JournalPloS one
Issue number12
Publication statusPublished - 2012 Dec 19
Externally publishedYes

ASJC Scopus subject areas

  • General Biochemistry,Genetics and Molecular Biology
  • General Agricultural and Biological Sciences
  • General


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