TY - GEN
T1 - Ultrasound-triggered controlled release of nanoparticles from hydrogel microbeads by release-promoting particles
AU - Kubota, Takeshi
AU - Kurashina, Yuta
AU - Onoe, Hiroaki
N1 - Funding Information:
This work was partly supported by Grant-in Aid for Scientific Research (B) (18H03551), Japan Society for the Promotion of Science (JSPS), Japan.
Publisher Copyright:
© 2019 CBMS-0001.
PY - 2019
Y1 - 2019
N2 - We propose an ultrasound-triggered drug delivery system (DDS) with release promoting particles for long-term controlled drug release with low power ultrasound. By using a centrifugal fluidic device, we fabricated calcium alginate hydrogel microbeads containing fluorescent silica nano-particles as a drug model and tungsten micro-particles for promoting release. The silica nano-beads were efficiently released from the microbeads by the ultrasound because the tungsten micro-particles can receive the energy of the applied ultrasound. This ultrasound method will be a key technology of DDS for control of drug release with less burden on the patients.
AB - We propose an ultrasound-triggered drug delivery system (DDS) with release promoting particles for long-term controlled drug release with low power ultrasound. By using a centrifugal fluidic device, we fabricated calcium alginate hydrogel microbeads containing fluorescent silica nano-particles as a drug model and tungsten micro-particles for promoting release. The silica nano-beads were efficiently released from the microbeads by the ultrasound because the tungsten micro-particles can receive the energy of the applied ultrasound. This ultrasound method will be a key technology of DDS for control of drug release with less burden on the patients.
KW - Centrifugal microfluidics
KW - DDS
KW - Hydrogel
KW - Ultrasound
UR - http://www.scopus.com/inward/record.url?scp=85094964830&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85094964830&partnerID=8YFLogxK
M3 - Conference contribution
AN - SCOPUS:85094964830
T3 - 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019
SP - 756
EP - 757
BT - 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019
PB - Chemical and Biological Microsystems Society
T2 - 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019
Y2 - 27 October 2019 through 31 October 2019
ER -