@article{ad9026d5da79467f988ad8ecd03c2dda,
title = "Unified Total Synthesis of Pentacyclic Stemoamide-type Alkaloids",
abstract = "The collective synthesis of pentacyclic stemoamide-type alkaloids is recognized as a daunting task despite high demand for a comprehensive biological profiling of these natural products. In this Letter, we report a unified synthesis of seven pentacyclic alkaloids and two unnatural derivatives. The keys to success are (1) the chemoselective assembly of four five-membered building blocks, (2) the direct oxidation of pyrrolidine natural products to pyrrole derivatives, and (3) the stereodivergent construction of totally E- or Z-substituted butenolides.",
author = "Yasuki Soda and Yasukazu Sugiyama and Makoto Yoritate and Hayato Tajima and Kana Shibuya and Chisato Ogihara and Takeshi Oishi and Takaaki Sato and Noritaka Chida",
note = "Funding Information: This research was supported by a Grant-in-Aid for Scientific Research (C) from MEXT (18K05127), the Tobe Maki Foundation, the JGC-S Scholarship Foundation, the Kato Memorial Bioscience Foundation, and the Yoshida Scholarship Foundation (to Y. Soda). We thank Prof. Yang Ye, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, China for giving us precious advice, the H and C NMR spectra of protostemoamide ( 3 ), and the H NMR spectra of protostemonine ( 5 ) and isoprotostemonine ( 28 ). 1 13 1 Publisher Copyright: {\textcopyright} 2020 American Chemical Society.",
year = "2020",
month = oct,
day = "2",
doi = "10.1021/acs.orglett.0c02697",
language = "English",
volume = "22",
pages = "7502--7507",
journal = "Organic Letters",
issn = "1523-7060",
publisher = "American Chemical Society",
number = "19",
}