Unprecedented chemo-enzymatic synthesis of stereochemically pure 3-acetoxy-2-methyl-2-vinylcycloalkanones

Ken Ichi Fuhshuku, Mina Tomita, Takeshi Sugai

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)


A new approach to 3-acetoxy-2-methyl-2-vinylcyclohexanone and 3-acetoxy-2-methyl-2-vinylcyclopentanone in stereochemically pure state, by means of a combination of yeast-catalyzed reduction and subsequent radical β-fragmentation is described.

Original languageEnglish
Pages (from-to)1763-1767
Number of pages5
JournalTetrahedron Letters
Issue number8
Publication statusPublished - 2004 Feb 16


  • Hydroxyketone
  • Radical β-fragmentation
  • Substituted cyclohexanone
  • Substituted cyclopentanone

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry


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