Up-regulation of the Ire I-mediated signaling molecule, Bip, in ischemic rat brain

D. Ito, K. Tanaka, S. Suzuki, T. Dembo, A. Kosakai, Y. Fukuuchi

Research output: Contribution to journalArticlepeer-review

48 Citations (Scopus)


The endoplasmic reticulum (ER) is thought to play important roles in various neurological diseases via multifactorial and complex mechanisms. The Ire1-mediated signal is part of one ER signaling pathways; the signal induces the expression of an ER-resident protein, Bip/GRP78, and is thought to be involved in cell death under ER stress. In this study, we examined time-dependent Bip expression after transient middle cerebral artery occlusion and characterized the Bip-positive cells. Ire1- mediated molecules, Bip, were rapidly up-regulated in the ischemic area after 3.5 h recirculation. Their immunoreactivity continued to increase until 24-48h. Immunofluorescence staining revealed Bip up-regulation in ischemic neurons, which were TUNEL positive. Our studies suggest that the Ire1-mediated signal might be associated with ischemic neuronal damage.

Original languageEnglish
Pages (from-to)4023-4028
Number of pages6
Issue number18
Publication statusPublished - 2001 Dec 21


  • Cerebral ischemia
  • Endoplasmic reticulum
  • Rat
  • Stroke

ASJC Scopus subject areas

  • Neuroscience(all)


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