Upper gastrointestinal triple stenosis in a patient with trisomy 17p syndrome: Case report and literature review

Hiroko Ando; Hideki Mori; Kaoru Takabayashi; Noriko Matsuura; Tatsuhiro Masaoka; Juntaro Matsuzaki; Yoshimasa Saito; Motohiko Kato; Kenjiro Kosaki; Takanori Kanai

doi:10.1002/deo2.70043

Upper gastrointestinal triple stenosis in a patient with trisomy 17p syndrome: Case report and literature review

Hiroko Ando, Hideki Mori, Kaoru Takabayashi, Noriko Matsuura, Tatsuhiro Masaoka, Juntaro Matsuzaki, Yoshimasa Saito, Motohiko Kato, Kenjiro Kosaki, Takanori Kanai

Research output: Contribution to journal › Article › peer-review

Abstract

Upper gastrointestinal stenosis, which can be congenital or acquired, can lead to dysphagia. The association between trisomy 17p syndrome, a rare chromosomal abnormality, and upper gastrointestinal stenosis is unclear. A 20-year-old man diagnosed with trisomy 17p syndrome was referred to our department due to recurrent vomiting. Esophagogastroduodenoscopy revealed stenotic areas in the esophagus, stomach, and duodenum. The congenital gastrointestinal stenosis present in both the duodenum and esophagus suggested that the stasis and reflux of digestive fluids exacerbated stenosis in the stomach and esophagus. Gastric acid suppression therapy and endoscopic dilation of the esophagus and duodenum effectively resolved the patient's vomiting symptoms.

Original language	English
Article number	e70043
Journal	DEN Open
Volume	5
Issue number	1
DOIs	https://doi.org/10.1002/deo2.70043
Publication status	Published - 2025 Apr

Keywords

duodenal web
gastric ulcer
gastroesophageal reflux disease
trisomy 17p syndrome
upper gastrointestinal stenosis

ASJC Scopus subject areas

Gastroenterology
Internal Medicine
Surgery

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10.1002/deo2.70043

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title = "Upper gastrointestinal triple stenosis in a patient with trisomy 17p syndrome: Case report and literature review",

abstract = "Upper gastrointestinal stenosis, which can be congenital or acquired, can lead to dysphagia. The association between trisomy 17p syndrome, a rare chromosomal abnormality, and upper gastrointestinal stenosis is unclear. A 20-year-old man diagnosed with trisomy 17p syndrome was referred to our department due to recurrent vomiting. Esophagogastroduodenoscopy revealed stenotic areas in the esophagus, stomach, and duodenum. The congenital gastrointestinal stenosis present in both the duodenum and esophagus suggested that the stasis and reflux of digestive fluids exacerbated stenosis in the stomach and esophagus. Gastric acid suppression therapy and endoscopic dilation of the esophagus and duodenum effectively resolved the patient's vomiting symptoms.",

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T2 - Case report and literature review

AU - Ando, Hiroko

AU - Mori, Hideki

AU - Takabayashi, Kaoru

AU - Matsuura, Noriko

AU - Masaoka, Tatsuhiro

AU - Matsuzaki, Juntaro

AU - Saito, Yoshimasa

AU - Kato, Motohiko

AU - Kosaki, Kenjiro

AU - Kanai, Takanori

PY - 2025/4

Y1 - 2025/4

N2 - Upper gastrointestinal stenosis, which can be congenital or acquired, can lead to dysphagia. The association between trisomy 17p syndrome, a rare chromosomal abnormality, and upper gastrointestinal stenosis is unclear. A 20-year-old man diagnosed with trisomy 17p syndrome was referred to our department due to recurrent vomiting. Esophagogastroduodenoscopy revealed stenotic areas in the esophagus, stomach, and duodenum. The congenital gastrointestinal stenosis present in both the duodenum and esophagus suggested that the stasis and reflux of digestive fluids exacerbated stenosis in the stomach and esophagus. Gastric acid suppression therapy and endoscopic dilation of the esophagus and duodenum effectively resolved the patient's vomiting symptoms.

AB - Upper gastrointestinal stenosis, which can be congenital or acquired, can lead to dysphagia. The association between trisomy 17p syndrome, a rare chromosomal abnormality, and upper gastrointestinal stenosis is unclear. A 20-year-old man diagnosed with trisomy 17p syndrome was referred to our department due to recurrent vomiting. Esophagogastroduodenoscopy revealed stenotic areas in the esophagus, stomach, and duodenum. The congenital gastrointestinal stenosis present in both the duodenum and esophagus suggested that the stasis and reflux of digestive fluids exacerbated stenosis in the stomach and esophagus. Gastric acid suppression therapy and endoscopic dilation of the esophagus and duodenum effectively resolved the patient's vomiting symptoms.

KW - duodenal web

KW - gastric ulcer

KW - gastroesophageal reflux disease

KW - trisomy 17p syndrome

KW - upper gastrointestinal stenosis

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Upper gastrointestinal triple stenosis in a patient with trisomy 17p syndrome: Case report and literature review

Abstract

Keywords

ASJC Scopus subject areas

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