Uremic Solutes and Sarcopenia

Hiroshi Watanabe, Hiromasa Kato, Yuki Enoki, Hitoshi Maeda, Toru Maruyama

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Sarcopenia in chronic kidney disease (CKD) is characterized by muscle wasting and decreased muscle endurance. Many insights have been made into the molecular mechanisms of muscle atrophy in CKD. A persistent imbalance between protein synthesis and degradation causes a loss of muscle mass. A decrease in insulin/IGF-1-Akt-mTOR signaling and an increased ubiquitin–proteasome system have emerged as inducers of muscle loss. During muscle wasting, abnormal levels of reactive oxygen species (ROS) and inflammatory cytokines are detected in skeletal muscle. The increased ROS and inflammatory cytokine induce the expression of myostatin, a negative regulator of muscle growth. An impaired mitochondrial function also contributes to reduced muscle endurance. Uremic toxins such as indoxyl sulfate, p-cresyl sulfate, and parathyroid hormone have a negative effect on muscle mass and endurance by affecting protein synthesis and degradation in addition to mitochondrial function in skeletal muscle. Some potential therapeutic approaches based on the molecular mechanisms of muscle wasting in CKD are currently in the testing stages.

Original languageEnglish
Title of host publicationUremic Toxins and Organ Failure
PublisherSpringer Singapore
Pages131-147
Number of pages17
ISBN (Electronic)9789811577932
ISBN (Print)9789811577925
DOIs
Publication statusPublished - 2020 Jan 1

Keywords

  • Inflammation
  • Muscle atrophy
  • Oxidative stress
  • Sarcopenia
  • Uremic toxin

ASJC Scopus subject areas

  • General Medicine

Fingerprint

Dive into the research topics of 'Uremic Solutes and Sarcopenia'. Together they form a unique fingerprint.

Cite this