Urumamide, a novel chymotrypsin inhibitor with a β-amino acid from a marine cyanobacterium Okeania sp.

Yuki Kanamori; Arihiro Iwasaki; Shinpei Sumimoto; Kiyotake Suenaga

doi:10.1016/j.tetlet.2016.08.012

Urumamide, a novel chymotrypsin inhibitor with a β-amino acid from a marine cyanobacterium Okeania sp.

Yuki Kanamori, Arihiro Iwasaki, Shinpei Sumimoto, Kiyotake Suenaga

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

Urumamide, a novel cyclic depsipeptide that contains a β-amino acid, was isolated from a marine cyanobacterium Okeania sp. Its gross structure was determined by spectroscopic analyses, and the absolute configuration was established based on Marfey's analyses and chiral HPLC analyses of hydrolysis products. Biologically, urumamide inhibited the growth of human cancer cells. In addition, urumamide inhibited chymotrypsin.

Original language	English
Pages (from-to)	4213-4216
Number of pages	4
Journal	Tetrahedron Letters
Volume	57
Issue number	37
DOIs	https://doi.org/10.1016/j.tetlet.2016.08.012
Publication status	Published - 2016

Keywords

Depsipeptide
Marine cyanobacteria
Okeania
Urumamide
β-Amino acid

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.tetlet.2016.08.012

Cite this

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title = "Urumamide, a novel chymotrypsin inhibitor with a β-amino acid from a marine cyanobacterium Okeania sp.",

abstract = "Urumamide, a novel cyclic depsipeptide that contains a β-amino acid, was isolated from a marine cyanobacterium Okeania sp. Its gross structure was determined by spectroscopic analyses, and the absolute configuration was established based on Marfey's analyses and chiral HPLC analyses of hydrolysis products. Biologically, urumamide inhibited the growth of human cancer cells. In addition, urumamide inhibited chymotrypsin.",

keywords = "Depsipeptide, Marine cyanobacteria, Okeania, Urumamide, β-Amino acid",

author = "Yuki Kanamori and Arihiro Iwasaki and Shinpei Sumimoto and Kiyotake Suenaga",

note = "Funding Information: This work was supported by JSPS KAKENHI Grant Number 16H03285 . Publisher Copyright: {\textcopyright} 2016",

year = "2016",

doi = "10.1016/j.tetlet.2016.08.012",

language = "English",

volume = "57",

pages = "4213--4216",

journal = "Tetrahedron Letters",

issn = "0040-4039",

publisher = "Elsevier Limited",

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TY - JOUR

T1 - Urumamide, a novel chymotrypsin inhibitor with a β-amino acid from a marine cyanobacterium Okeania sp.

AU - Kanamori, Yuki

AU - Iwasaki, Arihiro

AU - Sumimoto, Shinpei

AU - Suenaga, Kiyotake

PY - 2016

Y1 - 2016

N2 - Urumamide, a novel cyclic depsipeptide that contains a β-amino acid, was isolated from a marine cyanobacterium Okeania sp. Its gross structure was determined by spectroscopic analyses, and the absolute configuration was established based on Marfey's analyses and chiral HPLC analyses of hydrolysis products. Biologically, urumamide inhibited the growth of human cancer cells. In addition, urumamide inhibited chymotrypsin.

AB - Urumamide, a novel cyclic depsipeptide that contains a β-amino acid, was isolated from a marine cyanobacterium Okeania sp. Its gross structure was determined by spectroscopic analyses, and the absolute configuration was established based on Marfey's analyses and chiral HPLC analyses of hydrolysis products. Biologically, urumamide inhibited the growth of human cancer cells. In addition, urumamide inhibited chymotrypsin.

KW - Depsipeptide

KW - Marine cyanobacteria

KW - Okeania

KW - Urumamide

KW - β-Amino acid

UR - http://www.scopus.com/inward/record.url?scp=84983089397&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84983089397&partnerID=8YFLogxK

U2 - 10.1016/j.tetlet.2016.08.012

DO - 10.1016/j.tetlet.2016.08.012

M3 - Article

AN - SCOPUS:84983089397

SN - 0040-4039

VL - 57

SP - 4213

EP - 4216

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 37

ER -

Urumamide, a novel chymotrypsin inhibitor with a β-amino acid from a marine cyanobacterium Okeania sp.

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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