Usefulness of a simple clinical risk prediction method, modified acef score, for transcatheter aortic valve implantation

Takahide Arai, Thierry Lefèvre, Kentaro Hayashida, Yusuke Watanabe, Stephen A. O’Connor, Thomas Hovasse, Mauro Romano, Philippe Garot, Erik Bouvier, Bernard Chevalier, Marie Claude Morice

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)


Background: We assessed the predictive accuracy of a simple risk score, modified age, creatinine clearance, ejection fraction (ACEFmodif) score, for outcome of transcatheter aortic valve implantation (TAVI). Methods and Results: We prospectively included 703 consecutive patients undergoing TAVI. Patients were divided into low, middle and high ACEFmodif tertiles. Increased ACEFmodif score was associated with a significantly higher 1-year mortality rate (22%, 28% and 36%, P<0.01) and higher risk of acute kidney injury (AKI; 10%, 10% and 22%, P<0.01). On multivariate logistic regression analysis, ACEFmodif score was the only independent predictor of AKI. On multivariate Cox regression, ACEFmodif score was an independent predictor of 1-year cumulative mortality. Although the area under curve (AUC) showed that all risk scores poorly predicted the incidence of AKI and 1-year cumulative mortality, ACEFmodif score was more efficient in predicting the incidence of AKI compared with STS, LES and ES II (AUC, 0.61, 0.55, 0.54, 0.57, respectively). Furthermore, ACEFmodif score had similar accuracy in predicting 1-year mortality compared with other risk scores (AUC, 0.61, 0.61, 0.61, 0.61, respectively). Conclusions: ACEFmodif score may provide useful information for predicting AKI, 30-day and 1-year mortality in patients undergoing TAVI, but these results need further confirmation.

Original languageEnglish
Pages (from-to)1496-1503
Number of pages8
JournalCirculation Journal
Issue number7
Publication statusPublished - 2015 Jun 9


  • Acute kidney injury
  • Creatinine clearance
  • Ejection fraction score
  • Modified age
  • Severe symptomatic aortic stenosis
  • Transcatheter aortic valve implantation

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


Dive into the research topics of 'Usefulness of a simple clinical risk prediction method, modified acef score, for transcatheter aortic valve implantation'. Together they form a unique fingerprint.

Cite this