Usefulness of Choline-PET for the detection of residual hemangiopericytoma in the skull base: Comparison with FDG-PET

Shin Ito; Junkichi Yokoyama; Hitoshi Yoshimoto; Masaki Yazawa; Kubota Kazuo; Makoto Hanaguri; Shinichi Ohba; Mitsuhisa Fujimaki; Katsuhisa Ikeda

doi:10.1186/1746-160X-8-3

Usefulness of Choline-PET for the detection of residual hemangiopericytoma in the skull base: Comparison with FDG-PET

Shin Ito, Junkichi Yokoyama, Hitoshi Yoshimoto, Masaki Yazawa, Kubota Kazuo, Makoto Hanaguri, Shinichi Ohba, Mitsuhisa Fujimaki, Katsuhisa Ikeda

Department of Plastic Surgery

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

Background: Choline is a new PET tracer that is useful for the detection of malignant tumor. Choline is a precursor of the biosynthesis of phosphatidylcholine, a major phospholipid in the cell membrane of eukaryotic cells. Malignant tumors have an elevated level of phosphatidylcholine in cell membrane. Thus, choline is a marker of tumor malignancy.Method: The patient was a 51-year-old man with repeated recurrent hemangiopericytoma in the skull base. We performed Choline-PET in this patient after various treatments and compared findings with those of FDG-PET.Results: Choline accumulated in this tumor, but FDG did not accumulate. We diagnosed this tumor as residual hemangiopericytoma and performed the resection of the residual tumor. FDG-PET is not appropriate for skull base tumor detection because uptake in the brain is very strong.Conclusion: We emphasize the usefulness of Choline-PET for the detection of residual hemangiopericytoma in the skull base after various treatments, compared with FDG-PET.

Original language	English
Article number	3
Journal	Head and Face Medicine
Volume	8
Issue number	1
DOIs	https://doi.org/10.1186/1746-160X-8-3
Publication status	Published - 2012 Feb 7

Keywords

Choline-pet
Hemangiopericytoma
Skull base tumor
Skullbase surgery

ASJC Scopus subject areas

Otorhinolaryngology
Dentistry(all)
Clinical Neurology

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@article{821633d52b9342d08a3e4dad6236da9d,

title = "Usefulness of Choline-PET for the detection of residual hemangiopericytoma in the skull base: Comparison with FDG-PET",

abstract = "Background: Choline is a new PET tracer that is useful for the detection of malignant tumor. Choline is a precursor of the biosynthesis of phosphatidylcholine, a major phospholipid in the cell membrane of eukaryotic cells. Malignant tumors have an elevated level of phosphatidylcholine in cell membrane. Thus, choline is a marker of tumor malignancy.Method: The patient was a 51-year-old man with repeated recurrent hemangiopericytoma in the skull base. We performed Choline-PET in this patient after various treatments and compared findings with those of FDG-PET.Results: Choline accumulated in this tumor, but FDG did not accumulate. We diagnosed this tumor as residual hemangiopericytoma and performed the resection of the residual tumor. FDG-PET is not appropriate for skull base tumor detection because uptake in the brain is very strong.Conclusion: We emphasize the usefulness of Choline-PET for the detection of residual hemangiopericytoma in the skull base after various treatments, compared with FDG-PET.",

keywords = "Choline-pet, Hemangiopericytoma, Skull base tumor, Skullbase surgery",

author = "Shin Ito and Junkichi Yokoyama and Hitoshi Yoshimoto and Masaki Yazawa and Kubota Kazuo and Makoto Hanaguri and Shinichi Ohba and Mitsuhisa Fujimaki and Katsuhisa Ikeda",

note = "Funding Information: Supported in part by a Grant for Clinical Cancer Research from the Ministry of Health, Labor, and Welfare of Japan.",

year = "2012",

month = feb,

day = "7",

doi = "10.1186/1746-160X-8-3",

language = "English",

volume = "8",

journal = "Head and Face Medicine",

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TY - JOUR

T1 - Usefulness of Choline-PET for the detection of residual hemangiopericytoma in the skull base

T2 - Comparison with FDG-PET

AU - Ito, Shin

AU - Yokoyama, Junkichi

AU - Yoshimoto, Hitoshi

AU - Yazawa, Masaki

AU - Kazuo, Kubota

AU - Hanaguri, Makoto

AU - Ohba, Shinichi

AU - Fujimaki, Mitsuhisa

AU - Ikeda, Katsuhisa

N1 - Funding Information: Supported in part by a Grant for Clinical Cancer Research from the Ministry of Health, Labor, and Welfare of Japan.

PY - 2012/2/7

Y1 - 2012/2/7

N2 - Background: Choline is a new PET tracer that is useful for the detection of malignant tumor. Choline is a precursor of the biosynthesis of phosphatidylcholine, a major phospholipid in the cell membrane of eukaryotic cells. Malignant tumors have an elevated level of phosphatidylcholine in cell membrane. Thus, choline is a marker of tumor malignancy.Method: The patient was a 51-year-old man with repeated recurrent hemangiopericytoma in the skull base. We performed Choline-PET in this patient after various treatments and compared findings with those of FDG-PET.Results: Choline accumulated in this tumor, but FDG did not accumulate. We diagnosed this tumor as residual hemangiopericytoma and performed the resection of the residual tumor. FDG-PET is not appropriate for skull base tumor detection because uptake in the brain is very strong.Conclusion: We emphasize the usefulness of Choline-PET for the detection of residual hemangiopericytoma in the skull base after various treatments, compared with FDG-PET.

AB - Background: Choline is a new PET tracer that is useful for the detection of malignant tumor. Choline is a precursor of the biosynthesis of phosphatidylcholine, a major phospholipid in the cell membrane of eukaryotic cells. Malignant tumors have an elevated level of phosphatidylcholine in cell membrane. Thus, choline is a marker of tumor malignancy.Method: The patient was a 51-year-old man with repeated recurrent hemangiopericytoma in the skull base. We performed Choline-PET in this patient after various treatments and compared findings with those of FDG-PET.Results: Choline accumulated in this tumor, but FDG did not accumulate. We diagnosed this tumor as residual hemangiopericytoma and performed the resection of the residual tumor. FDG-PET is not appropriate for skull base tumor detection because uptake in the brain is very strong.Conclusion: We emphasize the usefulness of Choline-PET for the detection of residual hemangiopericytoma in the skull base after various treatments, compared with FDG-PET.

KW - Choline-pet

KW - Hemangiopericytoma

KW - Skull base tumor

KW - Skullbase surgery

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Usefulness of Choline-PET for the detection of residual hemangiopericytoma in the skull base: Comparison with FDG-PET

Abstract

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