Vacuolar-type H+-ATPase inhibitory activity of synthetic analogues of the concanamycins: Is the hydrogen bond network involving the lactone carbonyl, the hemiacetal hydroxy group, and the C-19 hydroxy group essential for the biological activity of the concanamycins?

Yuya Yoshimoto; Takaaki Jyojima; Tsuyoshi Arita; Minoru Ueda; Masaya Imoto; Shuichi Matsumura; Kazunobu Toshima

doi:10.1016/S0960-894X(02)00806-5

Vacuolar-type H⁺-ATPase inhibitory activity of synthetic analogues of the concanamycins: Is the hydrogen bond network involving the lactone carbonyl, the hemiacetal hydroxy group, and the C-19 hydroxy group essential for the biological activity of the concanamycins?

Yuya Yoshimoto, Takaaki Jyojima, Tsuyoshi Arita, Minoru Ueda, Masaya Imoto, Shuichi Matsumura, Kazunobu Toshima

Department of Applied Chemistry

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

Synthetic analogue of the concanamycins, which lacks the hydrogen bond network existing in the concanamycin structure, retains vacuolar-type H⁺-ATPase (V-ATPase) inhibitory activity and induces apoptosis to cancer cells that overexpressing epidermal growth factor receptors (EGFR).

Original language	English
Pages (from-to)	3525-3528
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	12
Issue number	24
DOIs	https://doi.org/10.1016/S0960-894X(02)00806-5
Publication status	Published - 2002 Dec

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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Yoshimoto, Y., Jyojima, T., Arita, T., Ueda, M., Imoto, M., Matsumura, S., & Toshima, K. (2002). Vacuolar-type H⁺-ATPase inhibitory activity of synthetic analogues of the concanamycins: Is the hydrogen bond network involving the lactone carbonyl, the hemiacetal hydroxy group, and the C-19 hydroxy group essential for the biological activity of the concanamycins? Bioorganic and Medicinal Chemistry Letters, 12(24), 3525-3528. https://doi.org/10.1016/S0960-894X(02)00806-5

Vacuolar-type H⁺-ATPase inhibitory activity of synthetic analogues of the concanamycins: Is the hydrogen bond network involving the lactone carbonyl, the hemiacetal hydroxy group, and the C-19 hydroxy group essential for the biological activity of the concanamycins? / Yoshimoto, Yuya; Jyojima, Takaaki; Arita, Tsuyoshi et al.
In: Bioorganic and Medicinal Chemistry Letters, Vol. 12, No. 24, 12.2002, p. 3525-3528.

Research output: Contribution to journal › Article › peer-review

Yoshimoto, Y, Jyojima, T, Arita, T, Ueda, M, Imoto, M, Matsumura, S & Toshima, K 2002, 'Vacuolar-type H⁺-ATPase inhibitory activity of synthetic analogues of the concanamycins: Is the hydrogen bond network involving the lactone carbonyl, the hemiacetal hydroxy group, and the C-19 hydroxy group essential for the biological activity of the concanamycins?', Bioorganic and Medicinal Chemistry Letters, vol. 12, no. 24, pp. 3525-3528. https://doi.org/10.1016/S0960-894X(02)00806-5

Yoshimoto Y, Jyojima T, Arita T, Ueda M, Imoto M, Matsumura S et al. Vacuolar-type H⁺-ATPase inhibitory activity of synthetic analogues of the concanamycins: Is the hydrogen bond network involving the lactone carbonyl, the hemiacetal hydroxy group, and the C-19 hydroxy group essential for the biological activity of the concanamycins? Bioorganic and Medicinal Chemistry Letters. 2002 Dec;12(24):3525-3528. doi: 10.1016/S0960-894X(02)00806-5

Yoshimoto, Yuya ; Jyojima, Takaaki ; Arita, Tsuyoshi et al. / Vacuolar-type H⁺-ATPase inhibitory activity of synthetic analogues of the concanamycins : Is the hydrogen bond network involving the lactone carbonyl, the hemiacetal hydroxy group, and the C-19 hydroxy group essential for the biological activity of the concanamycins?. In: Bioorganic and Medicinal Chemistry Letters. 2002 ; Vol. 12, No. 24. pp. 3525-3528.

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