TY - GEN
T1 - Valiable frequency characteristics multi-channel on-chip patch-clamp system using 0.18 um CMOS technology
AU - Kubo, Masahiro
AU - Kosaka, Taro
AU - Miyawaki, Takanori
AU - Ito, Kohta
AU - Nakano, Nobuhiko
N1 - Publisher Copyright:
© 2016 IEEE.
Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2017/1/18
Y1 - 2017/1/18
N2 - Patch-clamp measurement system is one of the useful techniques in the field of Electrophysiology. This technique makes it possible to measure ion current and is expected to contribution of the treatment of neurological disease and elucidation of the neuronal activity. In this paper, we propose multi-channel patch-clamp measurement system. The system is composed of I-V converter, parasitic components compensation circuit, programmable gain amplifier, anti-aliasing filter, multiplexer, and serial to parallel converter. The current-to-voltage conversion rate of the whole system is a maximum 379 Gohm. The input referred current noise is achieved 1.86 pArms in simulation, 2.09 pArms in measurement. In order to fine tune the cutoff frequency of entire system, the variable capacitance is used for the filter. It is possible to eliminate the influence of variations between the channels in a multi-channel system. The system was fabricated using the 0.18um CMOS process. 8-channel system is implemented in a chip size of 2.5 mm times 5 mm.
AB - Patch-clamp measurement system is one of the useful techniques in the field of Electrophysiology. This technique makes it possible to measure ion current and is expected to contribution of the treatment of neurological disease and elucidation of the neuronal activity. In this paper, we propose multi-channel patch-clamp measurement system. The system is composed of I-V converter, parasitic components compensation circuit, programmable gain amplifier, anti-aliasing filter, multiplexer, and serial to parallel converter. The current-to-voltage conversion rate of the whole system is a maximum 379 Gohm. The input referred current noise is achieved 1.86 pArms in simulation, 2.09 pArms in measurement. In order to fine tune the cutoff frequency of entire system, the variable capacitance is used for the filter. It is possible to eliminate the influence of variations between the channels in a multi-channel system. The system was fabricated using the 0.18um CMOS process. 8-channel system is implemented in a chip size of 2.5 mm times 5 mm.
KW - Anti-aliasing filter
KW - Electrophysiology
KW - I-V converter
KW - Low-noise amplifier
KW - Patch-clamp measurement
KW - Programmable gain amplifier
UR - http://www.scopus.com/inward/record.url?scp=85015093073&partnerID=8YFLogxK
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U2 - 10.1109/ISPACS.2016.7824689
DO - 10.1109/ISPACS.2016.7824689
M3 - Conference contribution
AN - SCOPUS:85015093073
T3 - 2016 International Symposium on Intelligent Signal Processing and Communication Systems, ISPACS 2016
BT - 2016 International Symposium on Intelligent Signal Processing and Communication Systems, ISPACS 2016
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 2016 International Symposium on Intelligent Signal Processing and Communication Systems, ISPACS 2016
Y2 - 24 October 2016 through 27 October 2016
ER -