Value of labial salivary gland histopathology for diagnosis of Sjögren's syndrome in patients with anti-centromere antibody positivity

Masako Tsukamoto, Katsuya Suzuki, Kazuyuki Tsunoda, Kazuhiro Ikeura, Kaori Kameyama, Tsutomu Takeuchi

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


Aim/Introduction: Although anti-centromere antibody (ACA)+ Sjögren's syndrome (SS) is considered a subtype of SS, it was not included in the recent American College of Rheumatology/ European League Against Rheumatism (ACR/EULAR) SS classification criteria. ACA+ patients without anti-SS-A/Ro antibodies require salivary gland histopathology to fulfill the ACR/EULAR criteria for diagnosis of SS. We reviewed salivary gland histology among ACA+ patients referred for the diagnosis of SS using the ACR/EULAR and Japanese criteria which does not require biopsy. Method: Data from 147 ACA+ patients with dry eyes and/or mouth who visited our department were retrospectively analyzed. Clinical, immunological, and histological data were collected and statistically analyzed. Result: Sixty-five patients (44%) had undergone labial salivary gland biopsy. The frequency of dry mouth was higher in ACA+ patients who had undergone labial salivary gland biopsy than in those who had not (P =.046), while there were no differences in biopsy rates between patients with and without sclerodactyly (P =.51). According to the current ACR/EULAR classification criteria, Greenspan grade of 3 or 4 for labial salivary gland histopathology is required in patients without anti-SS-A/Ro antibody for the diagnosis of SS. Four patients with Greenspan grades <3 and anti-SS-A/Ro antibody met the criteria for SS. In 54 patients in which the ACR/EULAR criteria were met, 53 patients were diagnosed with SS using the Japanese criteria. Conclusion: In ACA+/anti-SS-A/Ro– antibody patients, agreement between ACR/EULAR and Japanese criteria sets was excellent. For easily classifying ACA+ patients as SS cases, salivary gland biopsy should be performed in ACA+ patients with dry symptoms to identify ACA+ patients.

Original languageEnglish
Pages (from-to)1024-1029
Number of pages6
JournalInternational Journal of Rheumatic Diseases
Issue number8
Publication statusPublished - 2020 Aug 1


  • Sjögren's syndrome
  • anti-SS-A/Ro antibody
  • centromere/IM

ASJC Scopus subject areas

  • Rheumatology


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