Various Endoscopic Features in Monomorphic Epitheliotropic Intestinal T-Cell Lymphoma

Yasuhiro Aoki, Tomohisa Sujino, Kaoru Takabayashi, Makoto Mutakuchi, Katsura Emoto, Naoki Hosoe, Haruhiko Ogata, Takanori Kanai

Research output: Contribution to journalReview articlepeer-review

4 Citations (Scopus)


A 77-year-old female who had an acute severe abdominal pain was taken to the emergency room in the previous hospital. CT scans showed jejunum and ileum wall thickening and fatty deposits around the small intestinal tract, and gastrointestinal perforation could not be ruled out. By using single anal and oral balloon endoscopy, we observed mild edema with petechial erythema, shallow erosions with edematous mucosa and ulcers with surrounded disrupted villous structures at the jejunum and ileum. Histological analysis revealed atypical lymphocytes infiltrating the small intestinal mucosa demonstrating intraepithelial lymphocytosis. Immunohistochemical staining revealed that CD3, CD7, and CD56 staining was positive, and CD4, CD5, and CD8 staining was negative in infiltrated lymphocytes. We made the diagnosis of monomorphic epitheliotropic intestinal T-cell lymphoma (MEITL) with the combination of HE staining and IHC. PET-CT showed abnormal uptake in irregular wall thickening of the small intestine, lymph nodes, ribs, spine and pelvic bone. She was treated with chemotherapy (etoposide, prednisolone, oncovin, cyclophosphamide, hydroxydaunorubicin) and is still alive 1 year after the diagnosis. We reported the various endoscopic findings in the same MEITL patient by using single balloon endoscopy. We also summarized endoscopic characteristics of MEITL patients.

Original languageEnglish
Pages (from-to)312-322
Number of pages11
JournalCase Reports in Gastroenterology
Issue number1
Publication statusPublished - 2021 Jan


  • Balloon endoscopy
  • Gastrointestinal lymphoma
  • Monomorphic epitheliotropic intestinal T-cell lymphoma
  • Small intestine

ASJC Scopus subject areas

  • Gastroenterology


Dive into the research topics of 'Various Endoscopic Features in Monomorphic Epitheliotropic Intestinal T-Cell Lymphoma'. Together they form a unique fingerprint.

Cite this