@article{cb37cf98cade4860b9fb41e80ae9511b,
title = "Virucidal effect of the mesoscopic structure of cac-717 on severe acute respiratory syndrome coronavirus-2",
abstract = "Here, the virucidal effect of calcium bicarbonate with a mesoscopic structure (CAC-717) on severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) was determined. Assays showed that CAC-717 had a strong virucidal effect on all examined SARS-CoV-2 isolates, including variant strains. The viral infectivity decreased within 15 s, and the virucidal activity of CAC-717 at a 1:49 ratio was similar to that of ethanol disinfectant. CAC-717 neutralization eliminated this viru-cidal effect, indicating that the alkaline condition of CAC-717 is important for virus inactivation and is an indicator of its mesoscopic structure and virucidal activity. The virucidal effect was observed in the presence of organic matter (bovine serum albumin). CAC-717 is a non-invasive and non-flammable substance with a low environmental burden, and its usefulness as a novel disinfectant has been confirmed.",
keywords = "CAC-717, Disinfectant, Mesoscopic structure, SARS-CoV-2",
author = "Takashi Yokoyama and Tomoyasu Nishimura and Yoshifumi Uwamino and Kenjiro Kosaki and Koichi Furusaki and Rumiko Onishi and Takashi Onodera and Makoto Haritani and Katsuaki Sugiura and Rikio Kirisawa and Naoki Hasegawa",
note = "Funding Information: Orix and Santa Mineral provided financial support to conduct the research and prepare the article. We thank Kashimura, S. for overseeing the BSL3 laboratory maintenance. We also thank Takayama-Ito, M. of the National Institute of Infectious Diseases for providing SARS-CoV-2 isolates and Yamada, S. for critically reading the manuscript. Funding Information: Conflicts of Interest: Santa Mineral Co., Ltd. supports the endowed laboratory of Environmental Science for Sustainable Development, Tokyo University (T.Y., T.O., M.H. and K.S.). Orix conducts joint business with Santa Mineral and supports the Department of Infectious Diseases, Keio University School of Medicine (T.Y., T.N., Y.U. and N.H.). The Mineral Activation Technical Research Center is supported by Santa Mineral Co., Ltd. (K.F.). RO presides over Santa Mineral Co., Ltd. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results. Funding Information: Funding: Orix and Santa Mineral provided financial support to conduct the research and prepare the article. Publisher Copyright: {\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland.",
year = "2021",
month = oct,
doi = "10.3390/microorganisms9102096",
language = "English",
volume = "9",
journal = "Microorganisms",
issn = "2076-2607",
publisher = "MDPI AG",
number = "10",
}