Viscometric and electron microscopic analysis of effects of griseofulvin and its derivatives on in vitro polymerization of microtubule proteins and depolymerization of microtubules

Yoshihiro Sato; Takako Tezuka; Taiko Oda; Hiroshi Jun Hosoi

doi:10.1248/bpb1978.7.156

Viscometric and electron microscopic analysis of effects of griseofulvin and its derivatives on in vitro polymerization of microtubule proteins and depolymerization of microtubules

Yoshihiro Sato, Takako Tezuka, Taiko Oda, Hiroshi Jun Hosoi

School of Pharmacy

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

Griseofulvin and its sixteen derivatives were investigated by viscometry to examine their effects on in vitro polymerization and aggregation of microtubule proteins and depolymerization of microtubules. Of these compounds, eight pairs of enantiomers were compared in their activities. Electron microscopic studies were performed in several samples. The results indicate that in the C ring moiety of griseofulvin derivatives natural (+)-griseofulvin structure is essential to show their functions on microtubule proteins and microtubules.

Original language	English
Pages (from-to)	156-163
Number of pages	8
Journal	Journal of Pharmacobio-Dynamics
Volume	7
Issue number	3
DOIs	https://doi.org/10.1248/bpb1978.7.156
Publication status	Published - 1984 Jan 1

Keywords

aggregation
depolymerization
electron microscopy
enantiomer
griseofulvin derivative
microtubule
polymerization
structure activity relationship
viscometry

ASJC Scopus subject areas

Pharmacology

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10.1248/bpb1978.7.156

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Viscometric and electron microscopic analysis of effects of griseofulvin and its derivatives on in vitro polymerization of microtubule proteins and depolymerization of microtubules. / Sato, Yoshihiro; Tezuka, Takako; Oda, Taiko et al.
In: Journal of Pharmacobio-Dynamics, Vol. 7, No. 3, 01.01.1984, p. 156-163.

Research output: Contribution to journal › Article › peer-review

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Viscometric and electron microscopic analysis of effects of griseofulvin and its derivatives on in vitro polymerization of microtubule proteins and depolymerization of microtubules

Abstract

Keywords

ASJC Scopus subject areas

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