Enterprises and information societies confront crucial challenges currently, while Society 5.0 should contribute to a super smart society, especially for healthcare. Human computer interaction (HCI)—artificial intelligence (AI) digital healthcare platforms are architected to improve the healthcare status of patients with lifestyle-related diseases such as diabetes, and osteoporosis. Furthermore, the above digital platforms are expected to help control costs in the healthcare ecosystem. However, current digital enterprise architecture approaches have not achieved their full potential, especially in the healthcare sector. In this paper, we describe how the adaptive integrated digital architecture framework (AIDAF) with the HCI-AI integrated digital healthcare platform is proposed with a planned case of a university hospital in the Americas. In addition, challenges and future activities for this area are discussed that cover the directions for Society 5.0. We argue that the design of an open healthcare platform “Open Healthcare Platform 2030 - OHP2030” for medical product design and robotics can be developed with AIDAF. The vision of AIDAF applications to enable Society 5.0 in the OHP2030 research initiative is explained.