Water-soluble fullerene derivatives for drug discovery

Shigeo Nakamura, Tadahiko Mashino

Research output: Contribution to journalReview articlepeer-review

40 Citations (Scopus)


Fullerenes (represented by buckminsterfullerene, C60) are a new kind of organic compound with a cage-like structure. A great deal of attention has been focused on their unique properties. From the viewpoint of drug discovery, fullerenes could be novel lead compounds for drug discovery. However, fullerenes are poorly soluble in aqueous media. Incorporation of water-soluble groups into the fullerene core enables investigation of its biological activities. Certain fullerene derivatives show inhibitory activity against human immunodeficiency virus reverse transcriptase. Hepatitis C virus RNA polymerase is also inhibited by fullerene derivatives. Therefore, fullerene derivatives are candidate antiviral agents. In addition, fullerene derivatives exhibit antiproliferative activity by inducing apoptosis related to the generation of reactive oxygen species. Fullerene derivatives also have the potential to be anticancer drugs.

Original languageEnglish
Pages (from-to)248-254
Number of pages7
JournalJournal of Nippon Medical School
Issue number4
Publication statusPublished - 2012 Aug


  • Antitumor agents
  • Apoptosis
  • Fullerenes
  • Human immunodeficiency virus reverse transcriptase
  • Reactive oxygen species

ASJC Scopus subject areas

  • Medicine(all)


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