When a model learned in a domain is applied to a different domain, even if in the same task, there is no guarantee of accuracy. This is a very important issue when deep learning and machine learning are applied in the field. In medical applications, there is a wide variety of domain bias, making it very difficult to create a model appropriate for all domains. Furthermore, semantic segmentation needs fine annotation and its high labor cost makes its application difficult. Histopathological image segmentation enables drug discovery and medical image analysis, but it is expensive due to its annotation cost and the need for the skills of histopathological experts. In this paper, we focus on a weakly supervised method using point annotation unique to histopathological image segmentation, and tackled on weakly supervised domain adaptation to suppress domain gaps. Providing point level annotation instead of fine annotation decreases the high cost of labor normally required.