When albumin meets liposomes: A feasible drug carrier for biomedical applications

Kazuaki Taguchi, Yuko Okamoto, Kazuaki Matsumoto, Masaki Otagiri, Victor Tuan Giam Chuang

Research output: Contribution to journalReview articlepeer-review

19 Citations (Scopus)


Albumin, the most abundant protein in plasma, possesses some inherent beneficial structural and physiological characteristics that make it suitable for use as a drug delivery agent, such as an extraordinary drug-binding capacity and long blood retention, with a high biocompatibility. The use of these characteristics as a nanoparticle drug delivery system (DDS) offers several advantages, including a longer circulation time, lower toxicity, and more significant drug loading. To date, many innovative liposome preparations have been developed in which albumin is involved as a DDS. These novel albumin-containing liposome preparations show superior deliverability for genes, hydrophilic/hydrophobic substances and proteins/peptides to the targeting area compared to original liposomes by virtue of their high biocompatibility, stability, effective loading content, and the capacity for targeting. This review summarizes the current status of albumin applications in liposome-based DDS, focusing on albumin-coated liposomes and albumin-encapsulated liposomes as a DDS carrier for potential medical applications.

Original languageEnglish
Article number296
Issue number4
Publication statusPublished - 2021 Apr


  • Albumin
  • Drug delivery
  • Enhanced permeability retention effect
  • Liposome
  • Protein

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmaceutical Science
  • Drug Discovery


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