Whole-genome analysis of human papillomavirus type 16 prevalent in japanesewomen with or without cervical lesions

Yusuke Hirose, Mamiko Onuki, Yuri Tenjimbayashi, Mayuko Yamaguchi-Naka, Seiichiro Mori, Nobutaka Tasaka, Toyomi Satoh, Tohru Morisada, Takashi Iwata, Tohru Kiyono, Takashi Mimura, Akihiko Sekizawa, Koji Matsumoto, Iwao Kukimoto

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)


Recent large-scale genomics studies of human papillomaviruses (HPVs) have shown a high level of genomic variability of HPV16, the most prevalent genotype in HPV-associated malignancies, and provided new insights into the biological and clinical relevance of its genetic variations in cervical cancer development. Here, we performed deep sequencing analyses of the viral genome to explore genetic variations of HPV16 that are prevalent in Japan. A total of 100 complete genome sequences of HPV16 were determined from cervical specimens collected from Japanese women with cervical intraepithelial neoplasia and invasive cervical cancer, or without cervical malignancies. Phylogenetic analyses revealed the variant distribution in the Japanese HPV16 isolates; overall, lineage A was the most prevalent (94.0%), in which sublineage A4 was dominant (52.0%), followed by sublineage A1 (21.0%). The relative risk of sublineage A4 for cervical cancer development was significantly higher compared to sublineages A1/A2/A3 (odds ratio = 6.72, 95% confidence interval = 1.78–28.9). Interestingly, a novel cluster of variants that branched from A1/A2/A3 was observed for the Japanese HPV16 isolates, indicating that unique HPV16 variants are prevalent among Japanese women.

Original languageEnglish
Article number350
Issue number4
Publication statusPublished - 2019 Apr


  • Cervical cancer
  • HPV16
  • Papillomavirus
  • Variant

ASJC Scopus subject areas

  • Infectious Diseases
  • Virology


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