Wilson's Disease Associated with Olfactory Paranoid Syndrome and Idiopathic Thrombocytopenic Purpura

Morihiko Sagawa, Masaki Takao, Shigeru Nogawa, Masafumi Mizuno, Mitsuru Murata, Takahiro Amano, Atsuo Koto

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17 Citations (Scopus)


In this study we report an individual of Wilson's disease associated with olfactory paranoid syndrome and idiopathic thrombocytopenic purpura. The initial symptom of this female patient was olfactory paranoia at age 17. Although that psychiatric symptom was well controlled under pharmacological treatment for two years, she developed olfactory paranoia as well as sialorrhea, dysarthria and finger tremor at age 20. A year later rigidity was also present in the extremities. At age 23, idiopathic thrombocytopenic purpura was found based on hematological examinations. Because her extrapyramidal symptoms were progressive, she was referred to our department to evaluate her neurologic condition. She was diagnosed as having Wilson's disease based on (1) the presence of Kayser-Fleischer rings, (2) extrapyramidal signs, and (3) a decreased level of serum copper and ceruloplasmin. T2 and FLAIR images of brain MRI showed hyperintense lesions in the putamen, thalamus and pontine tegmentum. Diffusion-weighted images also showed hyperintense lesions in the thalamus and pontine tegmentum. The biopsy specimen of the liver revealed chronic hepatitis with copper accumulation. Since D-penicillamine treatment was initiated, she has shown no olfactory paranoia and exacerbation of ITP. Her gait disturbance has also improved. Olfactory paranoia and ITP are rare clinical complications of Wilson's disease. Further analysis may warrant consideration of the pathophysiological mechanism of the psychiatric, hematological and neuroradiological condition seen in Wilson's disease.

Original languageEnglish
Pages (from-to)899-902
Number of pages4
JournalBrain and Nerve
Issue number10
Publication statusPublished - 2003 Oct


  • Idiopathic thrombocytopenic purpura
  • MRI
  • Olfactory paranoid syndrome
  • Wilson disease

ASJC Scopus subject areas

  • General Neuroscience


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