TY - JOUR
T1 - Work-related psychosocial factors and inflammatory markers
T2 - A systematic review and meta-analysis
AU - Eguchi, Hisashi
AU - Watanabe, Kazuhiro
AU - Kawakami, Norito
AU - Ando, Emiko
AU - Imamura, Kotaro
AU - Sakuraya, Asuka
AU - Sasaki, Natsu
AU - Inoue, Akiomi
AU - Tsuno, Kanami
AU - Otsuka, Yasumasa
AU - Inoue, Reiko
AU - Nishida, Norimitsu
AU - Iwanaga, Mai
AU - Hino, Ayako
AU - Shimazu, Akihito
AU - Tsutsumi, Akizumi
N1 - Funding Information:
This study was financially supported by Japan Society for the Promotion of Science (JSPS) KAKENHI (Grant-in-Aid for Young Scientists) Grant Number 20K18941 , Industrial Diseases Clinical Research Grant 2018 ( 180701-01 ) and Industrial Diseases Clinical Research Grant 2021 (200401-01) from the Ministry of Health, Labour and Welfare, Japan . The funders had no involvement in study design, in the collection, analysis, and interpretation of data, in the writing of the report, or in the decision to submit the article for publication.
Publisher Copyright:
© 2023
PY - 2023/7
Y1 - 2023/7
N2 - Objective: We conducted a systematic review and meta-analysis to evaluate the prospective effect of adverse work-related psychosocial factors on increases in inflammatory markers. Methods: A systematic literature search was conducted in PubMed, Embase, PsycINFO, PsycARTICLES, and the Japan Medical Abstracts Society database. Studies were eligible for inclusion if they examined associations between work-related psychosocial factors and inflammatory markers (interleukin-6, tumor necrosis factor-alpha, and C-reactive protein), used longitudinal or prospective cohort designs, were conducted among workers, were original articles written in English or Japanese, and were published up to 2017 for the first search, October 2020 for the second, and November 2022 for the third. A meta-analysis was conducted using a random-effects model to assess the pooled effect size for the associations. A meta-regression analysis was used to estimate the association between length of follow-up and effect size. The ROBINS-I tool was used to assess risk of bias. Results: Of the 11,121 studies identified in the first search, 29,135 studies from the second, and 9448 studies from the third, eleven were eligible for this review and meta-analysis. The pooled coefficient between adverse work-related psychosocial factors and inflammatory markers was significant and positive (β = 0.014, 95% confidence interval: 0.005–0.023). However, a clear association was only observed for interleukin-6, and all the studies included had serious risks of bias. Meta-regression showed the effect size decreased depending on the follow-up period. Conclusion: This study revealed a weak positive association between adverse work-related psychosocial factors and increases in inflammatory markers. Trial registration: PROSPERO CRD42018081553 (https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=81553).
AB - Objective: We conducted a systematic review and meta-analysis to evaluate the prospective effect of adverse work-related psychosocial factors on increases in inflammatory markers. Methods: A systematic literature search was conducted in PubMed, Embase, PsycINFO, PsycARTICLES, and the Japan Medical Abstracts Society database. Studies were eligible for inclusion if they examined associations between work-related psychosocial factors and inflammatory markers (interleukin-6, tumor necrosis factor-alpha, and C-reactive protein), used longitudinal or prospective cohort designs, were conducted among workers, were original articles written in English or Japanese, and were published up to 2017 for the first search, October 2020 for the second, and November 2022 for the third. A meta-analysis was conducted using a random-effects model to assess the pooled effect size for the associations. A meta-regression analysis was used to estimate the association between length of follow-up and effect size. The ROBINS-I tool was used to assess risk of bias. Results: Of the 11,121 studies identified in the first search, 29,135 studies from the second, and 9448 studies from the third, eleven were eligible for this review and meta-analysis. The pooled coefficient between adverse work-related psychosocial factors and inflammatory markers was significant and positive (β = 0.014, 95% confidence interval: 0.005–0.023). However, a clear association was only observed for interleukin-6, and all the studies included had serious risks of bias. Meta-regression showed the effect size decreased depending on the follow-up period. Conclusion: This study revealed a weak positive association between adverse work-related psychosocial factors and increases in inflammatory markers. Trial registration: PROSPERO CRD42018081553 (https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=81553).
KW - C-reactive protein
KW - Interleukin-6
KW - Meta-analysis
KW - Psychosocial factor
KW - Tumor necrosis factor-alpha
KW - Workplace
UR - http://www.scopus.com/inward/record.url?scp=85162785026&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85162785026&partnerID=8YFLogxK
U2 - 10.1016/j.jpsychores.2023.111349
DO - 10.1016/j.jpsychores.2023.111349
M3 - Review article
C2 - 37187013
AN - SCOPUS:85162785026
SN - 0022-3999
VL - 170
JO - Journal of Psychosomatic Research
JF - Journal of Psychosomatic Research
M1 - 111349
ER -
