Work-related psychosocial factors and metabolic syndrome onset among workers: a systematic review and meta-analysis

K. Watanabe, A. Sakuraya, N. Kawakami, K. Imamura, E. Ando, Y. Asai, H. Eguchi, Y. Kobayashi, N. Nishida, H. Arima, A. Shimazu, A. Tsutsumi

Research output: Contribution to journalReview articlepeer-review

45 Citations (Scopus)


Background: Work-related psychosocial factors have been associated with metabolic syndrome. However, no systematic reviews or meta-analyses have evaluated this association. Methods: A systematic literature search was conducted, using PubMed, Embase, PsycINFO, PsycARTICLES and the Japan Medical Abstracts Society. Eligible studies included those that examined the previously mentioned association; had a longitudinal or prospective cohort design; were conducted among workers; provided sufficient data for calculating odds ratios, relative risks or hazard ratios with 95% confidence intervals; were original articles in English or Japanese; and were published no later than 2016. Study characteristics, exposure and outcome variables and association measures of studies were extracted by the investigators independently. Results: Among 4,664 identified studies, 8 were eligible for review and meta-analysis. The pooled risk of adverse work-related stress on metabolic syndrome onset was significant and positive (RR = 1.47; 95% CI, 1.22–1.78). Sensitivity analyses limiting only the effects of job strain and shift work also indicated a significant positive relationship (RR = 1.75; 95% CI, 1.09–2.79; and RR = 1.59; 95% CI, 1.00–2.54, P = 0.049 respectively). Conclusion: This study reveals a strong positive association between work-related psychosocial factors and an elevated risk of metabolic syndrome onset. The effects of job strain and shift work on metabolic syndrome appear to be significant.

Original languageEnglish
Pages (from-to)1557-1568
Number of pages12
JournalObesity Reviews
Issue number11
Publication statusPublished - 2018 Nov
Externally publishedYes


  • metabolic syndrome
  • psychosocial
  • worker
  • workplace

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Public Health, Environmental and Occupational Health


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