Wss1 Promotes Replication Stress Tolerance by Degrading Histones

Karthik Maddi, Daniel Kwesi Sam, Florian Bonn, Stefan Prgomet, Eric Tulowetzke, Masato Akutsu, Jaime Lopez-Mosqueda, Ivan Dikic

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)


Maddi et al. show that Wss1 degrades unincorporated histones to tolerate replication stress. Wss1 is a DNA-dependent metalloprotease that cleaves DNA-protein crosslinks to maintain genome stability. Unlike DNA-protein crosslink removal, Wss1 does not require interactions with Sumo or Cdc48 to act on histones that bind non-specifically to DNA.

Original languageEnglish
Pages (from-to)3117-3126.e4
JournalCell Reports
Issue number9
Publication statusPublished - 2020 Mar 3
Externally publishedYes


  • DNA-protein crosslinks
  • Ddi1
  • HU
  • Rad51
  • Wss1
  • histone H2A
  • histone H3
  • histone H4
  • hydroxyurea
  • metalloprotease
  • replication stress

ASJC Scopus subject areas

  • General Biochemistry,Genetics and Molecular Biology


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