TY - JOUR
T1 - X-rays vs. carbon-ion tumor therapy
T2 - Cytogenetic damage in lymphocytes
AU - Durante, Marco
AU - Yamada, Shigeru
AU - Ando, Koichi
AU - Furusawa, Yoshiya
AU - Kawata, Tetsuya
AU - Majima, Hideyuki
AU - Nakano, Takashi
AU - Tsujii, Hirohiko
N1 - Funding Information:
This work was partially supported by NIRS Research Project with Heavy Ions grant. During this research, Dr. Marco Durante was on leave of absence from University “Federico II” (Naples, Italy), supported by Science and Technology Agency (Japan) fellowship 196121.
PY - 2000/6/1
Y1 - 2000/6/1
N2 - Purpose: To measure chromosomal aberrations in peripheral blood lymphocytes from cancer patients treated with X-rays or carbon ions (C-ions). Methods and Materials: Blood samples from patients diagnosed for esophageal or uterine cervical cancer were obtained before, during, and at the end of the radiation treatment. The novel technique of interphase chromosome painting was used to detect aberrations in prematurely condensed chromosomes 2 and 4. The fraction of aberrant lymphocytes was measured as a function of the dose to the tumor volume. For comparison, blood samples were also exposed in vitro to X-rays or to carbon ions accelerated at the HIMAC. Results: C- ions were more efficient than X-rays in the induction of chromosomal aberrations in vitro. In patients with similar pathologies, tumor positions, and radiation field sizes, however, C-ions induced a lower fraction of aberrant lymphocytes than X-rays during the treatment. The initial slope of the dose-response curve for the induction of chromosomal aberrations during the treatment was correlated to the relative decrease in the number of white blood cells and lymphocytes during the treatment. Conclusion: C-ions induce a lower level of cytogenetic damage in lymphocytes than X-rays, reducing the risk of bone marrow morbidity. (C) 2000 Elsevier Science Inc.
AB - Purpose: To measure chromosomal aberrations in peripheral blood lymphocytes from cancer patients treated with X-rays or carbon ions (C-ions). Methods and Materials: Blood samples from patients diagnosed for esophageal or uterine cervical cancer were obtained before, during, and at the end of the radiation treatment. The novel technique of interphase chromosome painting was used to detect aberrations in prematurely condensed chromosomes 2 and 4. The fraction of aberrant lymphocytes was measured as a function of the dose to the tumor volume. For comparison, blood samples were also exposed in vitro to X-rays or to carbon ions accelerated at the HIMAC. Results: C- ions were more efficient than X-rays in the induction of chromosomal aberrations in vitro. In patients with similar pathologies, tumor positions, and radiation field sizes, however, C-ions induced a lower fraction of aberrant lymphocytes than X-rays during the treatment. The initial slope of the dose-response curve for the induction of chromosomal aberrations during the treatment was correlated to the relative decrease in the number of white blood cells and lymphocytes during the treatment. Conclusion: C-ions induce a lower level of cytogenetic damage in lymphocytes than X-rays, reducing the risk of bone marrow morbidity. (C) 2000 Elsevier Science Inc.
KW - Chromosomal aberrations
KW - Esophageal cancer
KW - Heavy-ion therapy
KW - Human lymphocytes
KW - Uterine cancer
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U2 - 10.1016/S0360-3016(00)00455-7
DO - 10.1016/S0360-3016(00)00455-7
M3 - Article
C2 - 10837966
AN - SCOPUS:0034212314
SN - 0360-3016
VL - 47
SP - 793
EP - 798
JO - International Journal of Radiation Oncology Biology Physics
JF - International Journal of Radiation Oncology Biology Physics
IS - 3
ER -
