Yeast-mediated synthesis of optically active diols with C2-symmetry and (R)-4-pentanolide

Hajime Ikeda, Eriko Sato, Takeshi Sugai, Hiromichi Ohta

Research output: Contribution to journalArticlepeer-review

50 Citations (Scopus)


Reduction of some diketones and a ketoacid with yeast, Pichia farinosa IAM 4682 was examined. The reduction of carbonyl groups proceeded highly selectively with an anti-Prelog fashion to give (R)-alcohols. (2R,5R)-2,5-Hexanediol (83% yd., >99% e.e., 95% d.e.), (2R,4R)-2,4-pentanediol (94% yd., >99% e.e., 98% d.e.), and (R)-pentanolide (67% yd., >99% e.e.) were highly efficiently obtained from the corresponding ketones. Effect of the structure of substrate on the stereochemical course as well as the selectivity were discussed.

Original languageEnglish
Pages (from-to)8113-8122
Number of pages10
Issue number24
Publication statusPublished - 1996 Jun 10

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry


Dive into the research topics of 'Yeast-mediated synthesis of optically active diols with C2-symmetry and (R)-4-pentanolide'. Together they form a unique fingerprint.

Cite this