Zonal distribution of sulfotransferase for phenol in olfactory sustentacular cells

Atsushi Miyawaki; Hiroshi Homma; Hiro Omi Tamura; Michio Matsui; Katsuhiko Mikoshiba

doi:10.1002/j.1460-2075.1996.tb00558.x

Zonal distribution of sulfotransferase for phenol in olfactory sustentacular cells

Atsushi Miyawaki, Hiroshi Homma, Hiro Omi Tamura, Michio Matsui, Katsuhiko Mikoshiba

School of Pharmacy

Research output: Contribution to journal › Article › peer-review

52 Citations (Scopus)

Abstract

We have immunolocalized phenol sulfotransferase (PST)G, an isoform of PST in sustentacular cells which reside in the dorso-medial portion of the nasal cavity of the mouse. The same topographical pattern of gene expression has been reported for some olfactory neuron-specific genes. When several established (phenol-containing) odorants were used as substrate, mouse nasal tissue cytosol showed a significant level of PST activity, as does mouse liver cytosol. This study is the first to demonstrate that gene expression in the olfactory sustentacular cells is also organized zonally, and indicates the involvement of sulfo-conjugation in olfactory perireceptor processes, such as odorant clearance and xenobiotic detoxification.

Original language	English
Pages (from-to)	2050-2055
Number of pages	6
Journal	EMBO Journal
Volume	15
Issue number	9
DOIs	https://doi.org/10.1002/j.1460-2075.1996.tb00558.x
Publication status	Published - 1996 May 1

Keywords

Olfactory epithelium
Perireceptor processes
Phenol sulfotransferase
Sustentacular cells

ASJC Scopus subject areas

Neuroscience(all)
Molecular Biology
Biochemistry, Genetics and Molecular Biology(all)
Immunology and Microbiology(all)

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10.1002/j.1460-2075.1996.tb00558.x

Cite this

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title = "Zonal distribution of sulfotransferase for phenol in olfactory sustentacular cells",

abstract = "We have immunolocalized phenol sulfotransferase (PST)G, an isoform of PST in sustentacular cells which reside in the dorso-medial portion of the nasal cavity of the mouse. The same topographical pattern of gene expression has been reported for some olfactory neuron-specific genes. When several established (phenol-containing) odorants were used as substrate, mouse nasal tissue cytosol showed a significant level of PST activity, as does mouse liver cytosol. This study is the first to demonstrate that gene expression in the olfactory sustentacular cells is also organized zonally, and indicates the involvement of sulfo-conjugation in olfactory perireceptor processes, such as odorant clearance and xenobiotic detoxification.",

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AU - Miyawaki, Atsushi

AU - Homma, Hiroshi

AU - Tamura, Hiro Omi

AU - Matsui, Michio

AU - Mikoshiba, Katsuhiko

PY - 1996/5/1

Y1 - 1996/5/1

N2 - We have immunolocalized phenol sulfotransferase (PST)G, an isoform of PST in sustentacular cells which reside in the dorso-medial portion of the nasal cavity of the mouse. The same topographical pattern of gene expression has been reported for some olfactory neuron-specific genes. When several established (phenol-containing) odorants were used as substrate, mouse nasal tissue cytosol showed a significant level of PST activity, as does mouse liver cytosol. This study is the first to demonstrate that gene expression in the olfactory sustentacular cells is also organized zonally, and indicates the involvement of sulfo-conjugation in olfactory perireceptor processes, such as odorant clearance and xenobiotic detoxification.

AB - We have immunolocalized phenol sulfotransferase (PST)G, an isoform of PST in sustentacular cells which reside in the dorso-medial portion of the nasal cavity of the mouse. The same topographical pattern of gene expression has been reported for some olfactory neuron-specific genes. When several established (phenol-containing) odorants were used as substrate, mouse nasal tissue cytosol showed a significant level of PST activity, as does mouse liver cytosol. This study is the first to demonstrate that gene expression in the olfactory sustentacular cells is also organized zonally, and indicates the involvement of sulfo-conjugation in olfactory perireceptor processes, such as odorant clearance and xenobiotic detoxification.

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KW - Perireceptor processes

KW - Phenol sulfotransferase

KW - Sustentacular cells

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Zonal distribution of sulfotransferase for phenol in olfactory sustentacular cells

Abstract

Keywords

ASJC Scopus subject areas

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