医学部基礎教室

2025

A case of immunoglobulin G4-related disease with a urethral lesion diagnosed by radiological imaging before biopsy

Yagi, F., Akita, H., Matsumoto, K., Arai, E., Meng, W., Furuya, K., Senda, S., Oya, M. & Jinzaki, M., 2025 4月, In: Abdominal Radiology. 50, 4, p. 1672-1678 7 p.

研究成果: Article › 査読

A case of testicular dysgenesis syndrome with squamous cell carcinoma of the prostate harboring a CDK12 mutation

Murata, Y., Kosaka, T., Nakamura, K., Baba, Y., Arai, E., Yasumizu, Y., Matsumoto, K., Nishihara, H. & Oya, M., 2025 3月, In: IJU Case Reports. 8, 2, p. 125-128 4 p.

研究成果: Article › 査読

Open Access

Advanced intrahepatic cholangiocarcinoma successfully treated with combined immunotherapy: focusing on the tumor immune microenvironment

Omoto, M., Sugimoto, K., Kurebayashi, Y., Kakegawa, T., Takahashi, H., Wada, T., Takeuchi, H., Nagao, T., Nagakawa, Y. & Itoi, T., 2025, (Accepted/In press) In: Clinical journal of gastroenterology.

研究成果: Article › 査読

Open Access

Aquaporin 3 inhibition attenuates imiquimod-induced psoriatic symptoms in a murine model

Okubo, R., Tanaka, M., Kubo, A., Yasui, M. & Hara-Chikuma, M., 2025 12月, In: Molecular Biology Reports. 52, 1, 354.

研究成果: Article › 査読

Open Access

Association of methotrexate polyglutamates concentration with methotrexate efficacy and safety in patients with rheumatoid arthritis treated with predefined dose: results from the MIRACLE trial

MIRACLE Study Group, 2025 1月, In: Annals of the rheumatic diseases. 84, 1, p. 41-48 8 p.

研究成果: Article › 査読

2 被引用数 (Scopus)

Being underweight or obese in adolescence may increase the risk of female infertility later in life: The Japan Nurses' Health Study

Iida, M., Ideno, Y., Nagai, K., Miyazaki, Y., Toki, R., Sato, Y., Iwasa, T., Arata, N., Kurabayashi, T. & Hayashi, K., 2025 2月, In: Maturitas. 193, 108172.

研究成果: Article › 査読

Open Access

Blood DNA virome associates with autoimmune diseases and COVID-19

Japan COVID-19 Task Force, 2025 1月, In: Nature genetics. 57, 1, p. 65-79 15 p., e20191766.

研究成果: Article › 査読

Open Access

1 被引用数 (Scopus)

Cathepsin C (dipeptidyl peptidase 1) inhibition in adults with bronchiectasis: AIRLEAF, a phase II randomised, double-blind, placebo-controlled, dose-finding study

Chalmers, J. D., Shteinberg, M., Mall, M. A., O'Donnell, A. E., Watz, H., Gupta, A., Frahm, E., Eleftheraki, A., Rauch, J., Chotirmall, S. H., Armstrong, A. W., Eickholz, P., Hasegawa, N., Sauter, W. & McShane, P. J., 2025, In: European Respiratory Journal. 65, 1, 2401551.

研究成果: Article › 査読

Open Access

8 被引用数 (Scopus)

Celecoxib prevents malignant progression of smoking-induced lung tumors via suppression of the COX-2/PGE₂ signaling pathway in mice

Sakurai, K., Chubachi, S., Miyata, J., Hamamoto, J., Naganuma, T., Shimada, T., Otake, S., Nakayama, S., Irie, H., Tsutsumi, A., Kameyama, N., Hegab, A. E., Shimoda, M., Terai, H., Yasuda, H., Kanai, Y., Arita, M. & Fukunaga, K., 2025, In: Frontiers in Immunology. 16, 1557790.

研究成果: Article › 査読

Open Access

Combined dual β-lactams and diazabicyclooctane β-lactamase inhibitor is highly effective against Mycobacterium abscessus species in vitro

Misawa, K., Nishimura, T., Yoshikawa, M., Shimamura, R., Kashimura, S., Enoki, Y., Taguchi, K., Matsumoto, K. & Hasegawa, N., 2025 5月, In: Journal of Global Antimicrobial Resistance. 42, p. 142-150 9 p.

研究成果: Article › 査読

Open Access

Correction to: A case of immunoglobulin G4-related disease with a urethral lesion diagnosed by radiological imaging before biopsy (Abdominal Radiology, (2024), 10.1007/s00261-024-04594-0)

Yagi, F., Akita, H., Matsumoto, K., Arai, E., Meng, W., Furuya, K., Senda, S., Oya, M. & Jinzaki, M., 2025, (Accepted/In press) In: Abdominal Radiology.

研究成果: Comment/debate › 査読

Corrigendum to ‘Impact of accumulative smoking exposure and chronic obstructive pulmonary disease on COVID-19 outcomes: report based on findings from the Japan COVID-19 task force’ [IJID 128 (2023) 121–127, (S1201971222006555), (10.1016/j.ijid.2022.12.019)]

The Japan COVID-19 Task Force, 2025 2月, In: International Journal of Infectious Diseases. 151, 107322.

研究成果: Comment/debate › 査読

Open Access

CTCF-mediated 3D chromatin sets up the gene expression program in the male germline

Kitamura, Y., Takahashi, K., Maezawa, S., Munakata, Y., Sakashita, A., Katz, S. P., Kaplan, N. & Namekawa, S. H., 2025, (Accepted/In press) In: Nature Structural and Molecular Biology. 4856.

研究成果: Article › 査読

Distributed representations of temporally accumulated reward prediction errors in the mouse cortex

Makino, H. & Suhaimi, A., 2025 1月 24, In: Science Advances. 11, 4, eadi4782.

研究成果: Article › 査読

Do mothers’ socioeconomic factors affect children’s sodium and potassium intake?

Miyagawa, N., 2025, (Accepted/In press) In: Hypertension Research.

研究成果: Comment/debate › 査読

Elevated hematopoietic stem cell frequency in mouse alveolar bone marrow

Niizuma, K., Morikawa, S., Gars, E., Xiang, J., Matsubara-Takahashi, T., Saito, R., Takematsu, E., Wang, Y., Xu, H., Wakimoto, A., Tan, T. K., Kubota, Y., Chan, C. K. F., Weissman, I. L., Nakagawa, T., Wilkinson, A. C., Nakauchi, H. & Yamamoto, R., 2025 1月 14, In: Stem cell reports. 20, 1, 102374.

研究成果: Article › 査読

Open Access

1 被引用数 (Scopus)

Exercise therapy can effectively improve trunk performance and sitting balance in spinal cord injury: a systematic review and meta-analysis

Okawara, H., Sawada, T., Onuki, S., Sugai, K., Okubo, T., Ozaki, M., Tsuji, O., Nagoshi, N., Sato, Y. & Nakamura, M., 2025 4月, In: Neurological Sciences. 46, 4, p. 1581-1597 17 p.

研究成果: Review article › 査読

Factors associated with the change of antimicrobial prescription before and after the national action plan on antimicrobial resistance: Additional analysis of a nationwide survey conducted by the Japanese Society of Chemotherapy and the Japanese Association for Infectious Diseases

Morioka, S., Tsuzuki, S., Gu, Y., Fujitomo, Y., Soeda, H., Nakahama, C., Hasegawa, N., Maesaki, S., Maeda, M., Matsumoto, T., Miyairi, I. & Ohmagari, N., 2025 2月, In: Journal of Infection and Chemotherapy. 31, 2, 102532.

研究成果: Article › 査読

Open Access

Ghrelin Promotes Lipid Uptake into White Adipose Tissue via Endothelial Growth Hormone Secretagogue-Receptor in Mice

Urai, H., Azegami, T., Komatsu, M., Takahashi, R., Kubota, Y., Hasegawa, K., Tokuyama, H., Wakino, S., Hayashi, K., Kanda, T. & Itoh, H., 2025 1月, In: Nutrients. 17, 1, 146.

研究成果: Article › 査読

Open Access

KRAB zinc-finger proteins regulate endogenous retroviruses to sculpt germline transcriptomes and genome evolution

Otsuka, K., Sakashita, A., Maezawa, S., Schultz, R. M. & Namekawa, S. H., 2025 3月, In: Genome Research. 35, 3, p. 417-431 15 p.

研究成果: Article › 査読

Open Access

MAPT-A152T mutation drives neuronal hyperactivity through Fyn-NMDAR signaling in human iPSC-Derived neurons: Insights into Alzheimer's pathogenesis

Itsuno, M., Tanabe, H., Sano, E., Sasaki, T., Oyama, C., Bannai, H., Saito, K., Nakata, K., Endoh-Yamagami, S., Okano, H. & Maeda, S., 2025 3月, In: Regenerative Therapy. 28, p. 201-213 13 p.

研究成果: Article › 査読

Open Access

Occupational health topics series on the effects of chemicals: epidemiological and toxicological risk assessments of ortho-toluidine for bladder cancer

Nakano, M., Gi, M., Toyooka, T., Suzuki, S., Wanibuchi, H. & Takebayashi, T., 2025 1月 1, In: Journal of occupational health. 67, 1, uiaf005.

研究成果: Review article › 査読

Open Access

Optimal incubation duration of liquid cultures for assessing culture negative conversion in patients with Mycobacterium avium complex and Mycobacterium abscessus pulmonary diseases

Uwamino, Y., Hasegawa, N., Kamoshita, Y., Inose, R., Aoki, W., Nagata, M., Namkoong, H., Nishimura, T. & Matsushita, H., 2025 1月, In: European Journal of Clinical Microbiology and Infectious Diseases. 44, 1, p. 45-51 7 p.

研究成果: Article › 査読

1 被引用数 (Scopus)

Pathological characteristics of inflammatory bowel diseases

Nakajima, M., Iwao, Y., Okabayashi, K., Kanai, Y. & Shimoda, M., 2025, (Accepted/In press) In: Journal of Medical Ultrasonics. 152608.

研究成果: Review article › 査読

Patient education status regarding peritoneal dialysis: a questionnaire-based survey study

Ryuzaki, M., Inoue, S., Morimoto, K., Wakabayashi, K., Yoshifuji, A., Komatsu, M., Fujii, K., Kato, A., Honjoh, H., Wakino, S., Uchiyama, K. & Itoh, H., 2025 12月, In: Renal Replacement Therapy. 11, 1, 8.

研究成果: Article › 査読

Open Access

Propagation of neuronal micronuclei regulates microglial characteristics

Yano, S., Asami, N., Kishi, Y., Takeda, I., Kubotani, H., Hattori, Y., Kitazawa, A., Hayashi, K., Kubo, K. I., Saeki, M., Maeda, C., Hiraki, C., Teruya, R. I., Taketomi, T., Akiyama, K., Okajima-Takahashi, T., Sato, B., Wake, H., Gotoh, Y. & Nakajima, K. & 4 others, Ichinohe, T., Nagata, T., Chiba, T. & Tsuruta, F., 2025 3月, In: Nature Neuroscience. 28, 3, p. 487-498 12 p., 12540.

研究成果: Article › 査読

Relationship between hearing thresholds and cognitive function in hearing aid non-users and long-term users post-midlife

Nishiyama, T., Kimizuka, T., Kataoka, C., Tazoe, M., Sato, Y., Hosoya, M., Shimanuki, M. N., Wakabayashi, T., Ueno, M., Ozawa, H. & Oishi, N., 2025 12月, In: npj Aging. 11, 1, 14.

研究成果: Article › 査読

Open Access

Targeting neutrophil serine proteases in bronchiectasis

Chalmers, J. D., Mall, M. A., Chotirmall, S. H., O’Donnell, A. E., Flume, P. A., Hasegawa, N., Ringshausen, F. C., Watz, H., Xu, J. F., Shteinberg, M. & McShane, P. J., 2025, In: European Respiratory Journal. 65, 1, 2401050.

研究成果: Review article › 査読

Open Access

3 被引用数 (Scopus)

2024

Aberrant cell adhesiveness due to DNA hypermethylation of KLF11 in papillary urothelial carcinomas

Tsumura, K., Fujimoto, M., Tian, Y., Kawahara, T., Fujimoto, H., Maeshima, A. M., Nakagawa, T., Kume, H., Yoshida, T., Kanai, Y. & Arai, E., 2024 6月, In: Experimental and Molecular Pathology. 137, 104908.

研究成果: Article › 査読

Open Access

2 被引用数 (Scopus)

Aberrant proximal tubule DNA methylation underlies phenotypic changes related to kidney dysfunction in patients with diabetes

Marumo, T., Yoshida, N., Inoue, N., Yamanouchi, M., Ubara, Y., Urakami, S., Fujii, T., Takazawa, Y., Ohashi, K., Kawarazaki, W., Nishimoto, M., Ayuzawa, N., Hirohama, D., Nagae, G., Fujimoto, M., Arai, E., Kanai, Y., Hoshino, J. & Fujita, T., 2024 9月, In: American Journal of Physiology - Renal Physiology. 327, 3, p. F397-F411

研究成果: Article › 査読

1 被引用数 (Scopus)

Abundant extrasynaptic expression of α3β4-containing nicotinic acetylcholine receptors in the medial habenula–interpeduncular nucleus pathway in mice

Tsuzuki, A., Yamasaki, M., Konno, K., Miyazaki, T., Takei, N., Tomita, S., Yuzaki, M. & Watanabe, M., 2024 12月, In: Scientific reports. 14, 1, 14193.

研究成果: Article › 査読

Open Access

1 被引用数 (Scopus)

A case of clear cell odontogenic carcinoma with an aggressive extension arising in the maxilla

Hashimoto, K., Muramoto, H., Suzuki, T., Kawachi, H., Nomura, T., Tanaka, Y. & Sasaki, A., 2024 3月, In: Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology. 36, 2, p. 247-252 6 p.

研究成果: Article › 査読

1 被引用数 (Scopus)

A case of community-acquired pneumonia caused by Bacillus subtilis subsp. natto in an immunocompetent patient

Tani, T., Takehara, T., Ishioka, K., Yoshifuji, A., Aoki, K. & Takahashi, S., 2024 5月, In: Respirology Case Reports. 12, 5, e01384.

研究成果: Article › 査読

Open Access

Activity-driven synaptic translocation of LGI1 controls excitatory neurotransmission

Cuhadar, U., Calzado-Reyes, L., Pascual-Caro, C., Aberra, A. S., Ritzau-Jost, A., Aggarwal, A., Ibata, K., Podgorski, K., Yuzaki, M., Geis, C., Hallerman, S., Hoppa, M. B. & de Juan-Sanz, J., 2024 5月 28, In: Cell Reports. 43, 5, 114186.

研究成果: Article › 査読

Open Access

3 被引用数 (Scopus)

Alcohol Consumption and Cerebral Small- and Large-Vessel Diseases: A Mendelian Randomization Analysis

Hisamatsu, T., Tabara, Y., Kadota, A., Torii, S., Kondo, K., Yano, Y., Shiino, A., Nozaki, K., Okamura, T., Ueshima, H. & Miura, K., 2024, In: Journal of atherosclerosis and thrombosis. 31, 2, p. 135-147 13 p.

研究成果: Article › 査読

Open Access

5 被引用数 (Scopus)

Amikacin liposome inhalation suspension for Mycobacterium avium complex pulmonary disease: A subgroup analysis of Japanese patients in the randomized, phase 3, CONVERT study

Morimoto, K., Nonaka, M., Yamazaki, Y., Nakagawa, T., Takasaki, J., Tsuyuguchi, K., Kitada, S., Jumadilova, Z., Yuen, D. W., Ciesielska, M. & Hasegawa, N., 2024 3月, In: Respiratory Investigation. 62, 2, p. 284-290 7 p.

研究成果: Article › 査読

Open Access

1 被引用数 (Scopus)

A Novel Organoid-Based Strategy Using Hybrid Colon Interposition for Short Bowel Syndrome: A Mini Review of In Vivo Models and Possible Human Candidates

Wada, M., Watanabe, K., Sugimoto, S., Sato, T. & Kobayashi, E., 2024 9月, In: Gastroenterology Clinics of North America. 53, 3, p. 481-491 11 p.

研究成果: Review article › 査読

A Novel Risk Score for Major Bleeding in Japanese Patients with Non-Valvular Atrial Fibrillation: The J-RISK AF Study

the J-RISK AF Research Group, 2024, In: Journal of atherosclerosis and thrombosis. 31, 11, p. 1591-1606 16 p.

研究成果: Article › 査読

Open Access

1 被引用数 (Scopus)

A pH imbalance is linked to autophagic dysregulation of inner ear hair cells in Atp6v1ba-deficient zebrafish

Ikeuchi, M., Inoue, M., Miyahara, H., Sebastian, W. A., Miyazaki, S., Takeno, T., Kiyota, K., Yano, S., Shiraishi, H., Shimizu, N., Hanada, R., Yoshimura, A., Ihara, K. & Hanada, T., 2024 3月 5, In: Biochemical and Biophysical Research Communications. 699, 149551.

研究成果: Article › 査読

1 被引用数 (Scopus)

A population-based urinary and plasma metabolomics study of environmental exposure to cadmium

Ishibashi, Y., Harada, S., Eitaki, Y., Kurihara, A., Kato, S., Kuwabara, K., Iida, M., Hirata, A., Sata, M., Matsumoto, M., Shibuki, T., Okamura, T., Sugiyama, D., Sato, A., Amano, K., Hirayama, A., Sugimoto, M., Soga, T., Tomita, M. & Takebayashi, T., 2024, In: Environmental Health and Preventive Medicine. 29, 22.

研究成果: Article › 査読

Open Access

3 被引用数 (Scopus)

Association between alcohol intake and death from cardiovascular diseases and its subtypes stratified by dyslipidemia in Japanese men: 20-years follow-up of NIPPON DATA90

Hirata, T., Hirata, A., Torii, S., Takashima, N., Kadota, A., Choudhury, S. R., Okayama, A., Miura, K. & Okamura, T., 2024, In: Environmental Health and Preventive Medicine. 29, 61.

研究成果: Article › 査読

Open Access

Association Between Awareness of Limiting Food Intake and All-cause Mortality: A Cohort Study in Japan

Japan Multi-Institutional Collaborative Cohort (J-MICC) Study Group, 2024, In: Journal of epidemiology. 34, 6, p. 286-294 9 p.

研究成果: Article › 査読

Open Access

Association between consumption of small fish and all-cause mortality among Japanese: the Japan Multi-Institutional Collaborative Cohort Study

Kasahara, C., Tamura, T., Wakai, K., Tamada, Y., Kato, Y., Kubo, Y., Okada, R., Nagayoshi, M., Hishida, A., Imaeda, N., Goto, C., Otonari, J., Ikezaki, H., Nishida, Y., Shimanoe, C., Oze, I., Koyanagi, Y. N., Nakamura, Y., Kusakabe, M. & Nishimoto, D. & 12 others, Shimoshikiryo, I., Suzuki, S., Watanabe, M., Ozaki, E., Omichi, C., Kuriki, K., Takashima, N., Miyagawa, N., Arisawa, K., Katsuura-Kamano, S., Takeuchi, K. & Matsuo, K., 2024 5月 3, In: Public Health Nutrition. 27, 1, e135.

研究成果: Article › 査読

Open Access

Association Between In-hospital Mortality and the Institutional Factors of Intensive Care Units with a Focus on the Intensivist- to-bed Ratio: A Retrospective Cohort Study

Endo, H., Okamoto, H., Hashimoto, S. & Miyata, H., 2024 10月, In: Journal of Intensive Care Medicine. 39, 10, p. 958-964 7 p.

研究成果: Article › 査読

Association of Nonalcoholic Fatty Liver Disease with Arterial Stiffness and its Metabolomic Profiling in Japanese Community-Dwellers

Hirata, A., Harada, S., Iida, M., Kurihara, A., Fukai, K., Kuwabara, K., Kato, S., Matsumoto, M., Sata, M., Miyagawa, N., Toki, R., Edagawa, S., Sugiyama, D., Sato, A., Hirayama, A., Sugimoto, M., Soga, T., Tomita, M., Okamura, T. & Takebayashi, T., 2024, In: Journal of atherosclerosis and thrombosis. 31, 7, p. 1031-1047 17 p.

研究成果: Article › 査読

Open Access

6 被引用数 (Scopus)

Association of Pro-Inflammatory Diet with Long-Term Risk of All-Cause and Cardiovascular Disease Mortality: NIPPON DATA80

Ganbaatar, G., Okami, Y., Kadota, A., Ganbaatar, N., Yano, Y., Kondo, K., Harada, A., Okuda, N., Yoshita, K., Okamura, T., Okayama, A., Ueshima, H. & Miura, K., 2024, In: Journal of atherosclerosis and thrombosis. 31, 3, p. 326-343 18 p.

研究成果: Article › 査読

Open Access

3 被引用数 (Scopus)

Association of step counts with cognitive function in apparently healthy middle-aged and older Japanese men

Shibukawa, T., Fujiyoshi, A., Moniruzzaman, M., Miyagawa, N., Kadota, A., Kondo, K., Saito, Y., Kadowaki, S., Hisamatsu, T., Yano, Y., Arima, H., Tooyama, I., Ueshima, H. & Miura, K., 2024 2月, In: Preventive Medicine Reports. 38, 102615.

研究成果: Article › 査読

Open Access

2 被引用数 (Scopus)

Benchmarking System Monitoring on Quality Improvement in Percutaneous Coronary Intervention: A Nationwide Registry in Japan

J-PCI Registry Investigators, 2024 4月, In: JACC: Asia. 4, 4, p. 323-331 9 p.

研究成果: Article › 査読

Open Access

1 被引用数 (Scopus)

Bidirectional associations of high-level cognitive domains with hand motor function and gait speed in high-functioning older adults: A 7-year study

Kobayashi-Cuya, K. E., Sakurai, R., Sakuma, N., Suzuki, H., Ogawa, S., Takebayashi, T. & Fujiwara, Y., 2024 2月, In: Archives of Gerontology and Geriatrics. 117, 105232.

研究成果: Article › 査読

5 被引用数 (Scopus)

Bioorthogonal chemical labeling of endogenous neurotransmitter receptors in living mouse brains

Nonaka, H., Sakamoto, S., Shiraiwa, K., Ishikawa, M., Tamura, T., Okuno, K., Kondo, T., Kiyonaka, S., Susaki, E. A., Shimizu, C., Ueda, H. R., Kakegawa, W., Arai, I., Yuzaki, M. & Hamachi, I., 2024, In: Proceedings of the National Academy of Sciences of the United States of America. 121, 6

研究成果: Article › 査読

Open Access

13 被引用数 (Scopus)

医学部基礎教室

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