医化学

2001

Macrophage-derived IL-18-mediated intestinal inflammation in the murine model of Crohn’s disease

Kanai, T., Watanabe, M., Okazawa, A., Sato, T., Yamazaki, M., Okamoto, S., Ishii, H., Totsuka, T., Iiyama, R., Okamoto, R., Ikeda, M., Kurimoto, M., Takeda, K., Akira, S. & Hibi, T., 2001, In: Gastroenterology. 121, 4, p. 875-888 14 p.

研究成果: Article › 査読

Open Access

177 被引用数 (Scopus)

Polaprezinc attenuates the Helicobacter pylori-induced gastric mucosal leucocyte activation in Mongolian gerbils - A study using intravital videomicroscopy

Suzuki, H., Mori, M., Seto, K., Miyazawa, M., Kai, A., Suematsu, M., Yoneta, T., Miura, S. & Ishii, H., 2001, In: Alimentary Pharmacology and Therapeutics. 15, 5, p. 715-725 11 p.

研究成果: Article › 査読

45 被引用数 (Scopus)

Professor Toshio Ito: A clairvoyant in pericyte biology

Suematsu, M. & Aiso, S., 2001 6月, In: Keio Journal of Medicine. 50, 2, p. 66-71 6 p.

研究成果: Review article › 査読

Open Access

24 被引用数 (Scopus)

Restricted V_H gene usage in lamina propria B cells producing anticolon antibody from patients with ulcerative colitis

Inoue, N., Watanabe, M., Sato, T., Okazawa, A., Yamazaki, M., Kanai, T., Ogata, H., Iwao, Y., Ishii, H. & Hibi, T., 2001, In: Gastroenterology. 121, 1, p. 15-23 9 p.

研究成果: Article › 査読

Open Access

14 被引用数 (Scopus)

2000

Daily regeneration of rat adrenocortical cells: Circadian and zonal variations in cytogenesis

Miyamoto, H., Mitani, F., Mukai, K., Suematsu, M. & Ishimura, Y., 2000, In: Endocrine Research. 26, 4, p. 899-904 6 p.

研究成果: Article › 査読

14 被引用数 (Scopus)

Immunoneutralization of glycoprotein Ibα attenuates endotoxin-induced interactions of platelets and leukocytes with rat venular endothelium in vivo

Katayama, T., Ikeda, Y., Handa, M., Tamatani, T., Sakamoto, S., Ito, M., Ishimura, Y. & Suematsu, M., 2000 5月 26, In: Circulation research. 86, 10, p. 1031-1037 7 p.

研究成果: Article › 査読

Open Access

77 被引用数 (Scopus)

Increased sensitivity to the C-X-C chemokine CINC/gro in a model of chronic inflammation

Johnston, B., Burns, A. R., Suematsu, M., Watanabe, K., Issekutz, T. B. & Kubes, P., 2000, In: Microcirculation. 7, 2, p. 109-118 10 p.

研究成果: Article › 査読

4 被引用数 (Scopus)

Protective roles of endogenous carbon monoxide in neointimal development elicited by arterial injury

Togane, Y., Morita, T., Suematsu, M., Ishimura, Y., Yamazaki, J. I. & Katayama, S., 2000 2月, In: American Journal of Physiology - Heart and Circulatory Physiology. 278, 2 47-2, p. H623-H632

研究成果: Article › 査読

117 被引用数 (Scopus)

Roles of ICAM-1 for abnormal leukocyte recruitment in the microcirculation of bleomycin-induced fibrotic lung injury

Sato, N., Suzuki, Y., Nishio, K., Suzuki, K., Naoki, K., Takeshita, K., Kudo, H., Miyao, N., Tsumura, H., Serizawa, H., Suematsu, M. & Yamaguchi, K., 2000, In: American journal of respiratory and critical care medicine. 161, 5, p. 1681-1688 8 p.

研究成果: Article › 査読

45 被引用数 (Scopus)

Stage-specific expression of mucosal addressin cell adhesion molecule-1 during embryogenesis in rats

Iizuka, T., Tanaka, T., Suematsu, M., Miura, S., Watanabe, T., Koike, R., Ishimura, Y., Ishii, H., Miyasaka, N. & Miyasaka, M., 2000 3月 1, In: Journal of Immunology. 164, 5, p. 2463-2471 9 p.

研究成果: Article › 査読

Open Access

48 被引用数 (Scopus)

The heme oxygenase-carbon monoxide system: A regulator of hepatobiliary function

Suematsu, M. & Ishimura, Y., 2000, In: Hepatology. 31, 1, p. 3-6 4 p.

研究成果: Review article › 査読

Open Access

122 被引用数 (Scopus)

X-ray crystal structure and catalytic properties of Thr252Ile mutant of cytochrome P450cam: Roles of Thr252 and water in the active center

Hishiki, T., Shimada, H., Nagano, S., Egawa, T., Kanamori, Y., Makino, R., Park, S. Y., Adachi, S. I., Shiro, Y. & Ishimura, Y., 2000 1月 1, In: Journal of biochemistry. 128, 6, p. 965-974 10 p.

研究成果: Article › 査読

53 被引用数 (Scopus)

1999

Carbon monoxide-mediated alterations in paracellular permeability and vesicular transport in acetaminophen-treated perfused rat liver

Mori, M., Suematsu, M., Kyokane, T., Sano, T., Suzuki, H., Yamaguchi, T., Ishimura, Y. & Ishii, H., 1999, In: Hepatology. 30, 1, p. 160-168 9 p.

研究成果: Article › 査読

Open Access

31 被引用数 (Scopus)

Carbon monoxide overproduced by heme oxygenase-1 causes a reduction of vascular resistance in perfused rat liver

Wakabayashi, Y., Takamiya, R., Mizuki, A., Kyokane, T., Goda, N., Yamaguchi, T., Takeoka, S., Tsuchida, E., Suematsu, M. & Ishimura, Y., 1999 11月, In: American Journal of Physiology - Gastrointestinal and Liver Physiology. 277, 5 40-5, p. G1088-G1096

研究成果: Article › 査読

62 被引用数 (Scopus)

Development of functional zonation in the rat adrenal cortex

Mitani, F., Mukai, K., Miyamoto, H., Suematsu, M. & Ishimura, Y., 1999, In: Endocrinology. 140, 7, p. 3342-3353 12 p.

研究成果: Article › 査読

Open Access

81 被引用数 (Scopus)

Kupffer cell-independent acute hepatocellular oxidative stress and decreased bile formation in post-cold-ischemic rat liver

Kumamoto, Y., Suematsu, M., Shimazu, M., Kato, Y., Sano, T., Makino, N., Hirano, K. I., Naito, M., Wakabayashi, G. O., Ishimura, Y. & Kitajima, M., 1999, In: Hepatology. 30, 6, p. 1454-1463 10 p.

研究成果: Article › 査読

Open Access

53 被引用数 (Scopus)

Microvascular oxidative stress, immune reaction and apoptosis in hypertensives

Suzuki, H., Suematsu, M. & Schmid-Schönbein, G. W., 1999, In: Clinical Hemorheology and Microcirculation. 21, 3-4, p. 161-168 8 p.

研究成果: Article › 査読

4 被引用数 (Scopus)

Nitric oxide inhibits microvascular protein leakage induced by leukocyte adhesion-independent and adhesion-dependent inflammatory mediators

Johnston, B., Gaboury, J. P., Suematsu, M. & Kubes, P., 1999, In: Microcirculation. 6, 2, p. 153-162 10 p.

研究成果: Article › 査読

32 被引用数 (Scopus)

Paracrine upregulation of VEGF receptor mRNA in endothelial cells by hypoxia-exposed Hep G2 cells

Suzuki, H., Seto, K., Shinoda, Y., Mori, M., Ishimura, Y., Suematsu, M. & Ishii, H., 1999 1月, In: American Journal of Physiology - Gastrointestinal and Liver Physiology. 276, 1 39-1, p. G92-G97

研究成果: Article › 査読

21 被引用数 (Scopus)

Putidaredoxin-cytochrome P450(cam) interaction: Spin state of the heme iron modulates putidaredoxin structure

Shimada, H., Nagano, S., Ariga, Y., Unno, M., Egawa, T., Hishiki, T., Ishimura, Y., Masuya, F., Obata, T. & Hori, H., 1999 4月 2, In: Journal of Biological Chemistry. 274, 14, p. 9363-9369 7 p.

研究成果: Article › 査読

Open Access

38 被引用数 (Scopus)

Recent advances in the vascular pathophysiology of heme oxygenase-carbon monoxide system

Suematsu, M., Makino, N. & Ishimura, Y., 1999 12月, In: Pathophysiology. 6, 3, p. 143-148 6 p.

研究成果: Article › 査読

Recent developments in hepatic circulatory physiology

Suematsu, M., 1999, In: Hepato-gastroenterology. 46, SUPPL. 2, p. 1406-1408 3 p.

研究成果: Short survey › 査読

6 被引用数 (Scopus)

Studies on cytogenesis in adult rat adrenal cortex: Circadian and zonal variations and their modulation by adrenocorticotropic hormone

Miyamoto, H., Mitani, F., Mukai, K., Suematsu, M. & Ishimura, Y., 1999, In: Journal of biochemistry. 126, 6, p. 1175-1183 9 p.

研究成果: Article › 査読

28 被引用数 (Scopus)

1998

Carbon monoxide as a regulator of bile canalicular contractility in cultured rat hepatocytes

Shinoda, Y., Suematsu, M., Wakabayashi, Y., Suzuki, T., Goda, N., Saito, S., Yamaguchi, T. & Ishimura, Y., 1998, In: Hepatology. 28, 2, p. 286-295 10 p.

研究成果: Article › 査読

60 被引用数 (Scopus)

CO overproduction is responcible for heme oxygenase 1-mediated microvascular hyporeactivity in perfused rat liver

Wakabayashi, Y., Takamiya, R., Mizuki, A., Suematsu, M. & Ishimura, Y., 1998 3月 20, In: FASEB Journal. 12, 5, p. A1001

研究成果: Article › 査読

Discontinuous total parenteral nutrition prevents postischemic mitochondrial dysfunction in rat liver

Morikawa, N., Suematsu, M., Kyokane, T., Goda, N., Kumamoto, Y., Okitsu, T., Ishimura, Y. & Kitajima, M., 1998, In: Hepatology. 28, 5, p. 1289-1299 11 p.

研究成果: Article › 査読

Open Access

15 被引用数 (Scopus)

Distribution of heme oxygenase isoforms in rat liver. Topographic basis for carbon monoxide-mediated microvascular relaxation

Goda, N., Suzuki, K., Naito, M., Takeoka, S., Tsuchida, E., Ishimura, Y., Tamatani, T. & Suematsu, M., 1998 2月 1, In: Journal of Clinical Investigation. 101, 3, p. 604-612 9 p.

研究成果: Article › 査読

Open Access

250 被引用数 (Scopus)

Distribution of heme oxygenase isoforms in rat liver characterized by novel monoclonal antibodies

Goda, N., Naito, M., Tamatani, T., Ishimura, Y. & Suematsu, M., 1998 3月 20, In: FASEB Journal. 12, 5, p. A1001

研究成果: Article › 査読

Effect of rebamipide on H. pylori-associated gastric mucosal injury in Mongolian gerbils

Suzuki, H., Mori, M., Kai, A., Suzuki, M., Suematsu, M., Miura, S. & Ishii, H., 1998, In: Digestive Diseases and Sciences. 43, 9 SUPPL., p. 181S-187S

研究成果: Article › 査読

14 被引用数 (Scopus)

Hepatocyte growth factor is a potent trigger of neutrophil adhesion through rapid activation of lymphocyte function-associated antigen-1

Mine, S., Tanaka, Y., Suematu, M., Aso, M., Fujisaki, T., Yamada, S. & Eto, S., 1998 11月, In: Laboratory Investigation. 78, 11, p. 1395-1404 10 p.

研究成果: Article › 査読

39 被引用数 (Scopus)

Modulation of P-selectin dependent leukocyte-endothelial cell interactions by inducible heme oxygenase in rat post-capillary venules in vivo

Takamiya, R., Hayashi, S., Goda, N., Wakabayashi, Y., Kitajima, M., Tamatani, T., Tojo, S., Ishimura, Y. & Suematsu, M., 1998 3月 20, In: FASEB Journal. 12, 5, p. A806

研究成果: Article › 査読

1997

Constitutive expression of ICAM-1 in rat microvascular systems analyzed by laser confocal microscopy

Iigo, Y., Suematsu, M., Higashida, T., Oheda, J. I., Matsumoto, K., Wakabayashi, Y., Ishimura, Y., Miyasaka, M. & Takashi, T., 1997, In: American Journal of Physiology - Heart and Circulatory Physiology. 42, 1

研究成果: Article › 査読

Constitutive expression of ICAM-1 in rat microvascular systems analyzed by laser confocal microscopy

Iigo, Y., Suematsu, M., Higashida, T., Oheda, J. I., Matsumoto, K., Wakabayashi, Y., Ishimura, Y., Miyasaka, M. & Takashi, T., 1997 7月, In: American Journal of Physiology - Heart and Circulatory Physiology. 273, 1 42-1, p. H138-H147

研究成果: Article › 査読

71 被引用数 (Scopus)

Effect of lipopolysaccharides on erythrocyte flow velocity in rat liver

Horie, Y., Kato, S., Ohki, E., Hamamatsu, H., Fukumura, D., Kurose, I., Suzuki, H., Suematsu, M., Miura, S. & Ishii, H., 1997 12月, In: Journal of gastroenterology. 32, 6, p. 783-790 8 p.

研究成果: Article › 査読

11 被引用数 (Scopus)

Electrophysiological characterization of cultured hepatic stellate cells in rats

Kashiwagi, S., Suematsu, M., Wakabayashi, Y., Kawada, N., Tachibana, M., Koizumi, A., Inoue, M., Ishimura, Y. & Kaneko, A., 1997 4月, In: American Journal of Physiology - Gastrointestinal and Liver Physiology. 272, 4 35-4, p. G742-G750

研究成果: Article › 査読

24 被引用数 (Scopus)

Endogenous carbon monoxide suppression stimulates bile acid-dependent biliary transport in perfused rat liver

Sano, T., Shiomi, M., Wakabayashi, Y., Shinoda, Y., Goda, N., Yamaguchi, T., Nimura, Y., Ishimura, Y. & Suematsu, M., 1997 5月, In: American Journal of Physiology - Gastrointestinal and Liver Physiology. 272, 5 35-5, p. G1268-G1275

研究成果: Article › 査読

40 被引用数 (Scopus)

Endothelial-derived nitric oxide preserves anticoagulant heparan sulfate expression in cultured porcine aortic endothelial cells

Irokawa, M., Nishinaga, M., Ikeda, U., Shinoda, Y., Suematsu, M., Gouda, N., Ishimura, Y. & Shimada, K., 1997 11月 1, In: Atherosclerosis. 135, 1, p. 9-17 9 p.

研究成果: Article › 査読

13 被引用数 (Scopus)

Enhanced lymphocyte interaction in postcapillary venules of Peyer's patches during fat absorption in rats

Tsuzuki, Y., Miura, S., Kurose, I., Suematsu, M., Higuchi, H., Shigematsu, T., Kimura, H., Serizawa, H., Hokari, R., Akiba, Y., Yagita, H., Okumura, K., Tso, P., Granger, D. N. & Ishii, H., 1997, In: Gastroenterology. 112, 3, p. 813-825 13 p.

研究成果: Article › 査読

21 被引用数 (Scopus)

Gaseous monoxides as an endogenous modulator of organ function--application of multifunctional digital microfluorography

Suematsu, M., Wakabayashi, Y. & Ishimura, Y., 1997 5月, In: Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme. 42, 7 Suppl, p. 1075-1079 5 p.

研究成果: Review article › 査読

Role of CD18-ICAM-1 in the entrapment of stimulated leukocytes in alveolar capillaries of perfused rat lungs

Aoki, T., Suzuki, Y., Nishio, K., Suzuki, K., Miyata, A., Iigou, Y., Serizawa, H., Tsumura, H., Ishimura, Y., Suematsu, M. & Yamaguchi, K., 1997, In: American Journal of Physiology - Heart and Circulatory Physiology. 273, 5 42-5, p. H2361-H2371

研究成果: Article › 査読

32 被引用数 (Scopus)

Vasoactive intestinal peptide modulates T lymphocyte migration in Peyer's patches of rat small intestine

Miura, S., Serizawa, H., Tsuzuki, Y., Kurose, I., Suematsu, M., Higuchi, H., Shigematsu, T., Hokari, R., Hirokawa, M., Kimura, H. & Ishii, H., 1997 1月, In: American Journal of Physiology - Gastrointestinal and Liver Physiology. 272, 1 35-1, p. G92-G99

研究成果: Article › 査読

13 被引用数 (Scopus)

1996

Gaseous monoxides: A new class of microvascular regulator in the liver

Suematsu, M., Wakabayashi, Y. & Ishimura, Y., 1996 10月, In: Cardiovascular Research. 32, 4, p. 679-686 8 p.

研究成果: Review article › 査読

91 被引用数 (Scopus)

Mitochondrial aldehyde dehydrogenase in diabetes associated with mitochondrial tRNA (Leu(UUR)) mutation at position 3243

Suzuki, Y., Muramatsu, T., Taniyama, M., Atsumi, Y., Suematsu, M., Kawaguchi, R., Higuchi, S., Asahina, T., Murata, C., Handa, M. & Matsuoka, K., 1996 12月, In: Diabetes care. 19, 12, p. 1423-1425 3 p.

研究成果: Article › 査読

23 被引用数 (Scopus)

Omeprazole attenuates oxygen-derived free radical production from human neutrophils

Suzuki, M., Mori, M., Miura, S., Suematsu, M., Fukumura, D., Kimura, H. & Ishii, H., 1996, In: Free Radical Biology and Medicine. 21, 5, p. 727-731 5 p.

研究成果: Article › 査読

108 被引用数 (Scopus)

Subthreshold UV light-induced peroxide formation in cultured corneal epithelial cells

Shimmura, S., Suematsu, M., Shimoyama, M., Tsubota, K., Oguchi, Y. & Ishimura, Y., 1996 2月 15, In: Investigative Ophthalmology and Visual Science. 37, 3, p. S355

研究成果: Article › 査読

Superoxide, NO and CO in liver microcirculation: Physiology and pathophysiology

Suematsu, M., Kumamoto, Y., Sano, T., Wakabayashi, Y. & Ishimura, Y., 1996 1月 1, In: Journal of Hepato-Biliary-Pancreatic Surgery. 3, 2, p. 154-160 7 p.

研究成果: Article › 査読

1995

Carbon monoxide: An endogenous modulator of sinusoidal tone in the perfused rat liver

Suematsu, M., Goda, N., Sano, T., Kashiwagi, S., Egawa, T., Shinoda, Y. & Ishimura, Y., 1995 11月, In: Journal of Clinical Investigation. 96, 5, p. 2431-2437 7 p.

研究成果: Article › 査読

Open Access

364 被引用数 (Scopus)

Impairment of selectin-mediated leukocyte adhesion to venular endothelium in spontaneously hypertensive rats

Suematsu, M., Suzuki, H., Tamatani, T., Iigou, Y., DeLano, F. A., Miyasaka, M., Forrest, M. J., Kannagi, R., Zweifach, B. W., Ishimura, Y. & Schmid-Schönbein, G. W., 1995 10月, In: Journal of Clinical Investigation. 96, 4, p. 2009-2016 8 p.

研究成果: Article › 査読

Open Access

44 被引用数 (Scopus)

Intravital demonstration of sequential migration process of lymphocyte subpopulations in rat peyer's patches

Miura, S., Tsuzuki, Y., Fukumura, D., Serizawa, H., Suematsu, M., Kurose, I., Imaeda, H., Kimura, H., Nagata, H., Tsuchiya, M. & Ishii, H., 1995 10月, In: Gastroenterology. 109, 4, p. 1113-1123 11 p.

研究成果: Article › 査読

37 被引用数 (Scopus)

1994

Carbon monoxide as an endogenous modulator of hepatic vascular perfusion

Suematsu, M., Kashiwagi, S., Sano, T., Goda, N., Shinoda, Y. & Ishimura, Y., 1994 12月 15, In: Biochemical and Biophysical Research Communications. 205, 2, p. 1333-1337 5 p.

研究成果: Article › 査読

142 被引用数 (Scopus)

研究成果

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