先端医科学研究所

研究成果

年別の研究成果 1984 2016 2017 2018 2020 2021 2023

• 424 Article
• 39 Review article
• 7 Chapter
• 6 Comment/debate
• 12 その他
  • 4 Conference contribution
  • 4 Letter
  • 2 Editorial
  • 2 Short survey

年別の研究成果

年別の研究成果

検索結果

• 2023

  Acceleration of the Development of Microcirculation Embolism in the Brain due to Capillary Narrowing

  Murata, J., Unekawa, M., Kudo, Y., Kotani, M., Kanno, I., Izawa, Y., Tomita, Y., Tanaka, K. F., Nakahara, J. & Masamoto, K., 2023 8月 1, In: Stroke. 54, 8, p. 2135-2144 10 p.

  研究成果: Article › 査読

  • Intracranial Embolism 100%
  • Microcirculation 77%
  • Acceleration 72%
  • Capillaries 71%
  • Channelrhodopsins 45%

• A novel tdTomato transgenic mouse model to visualize FAP-positive cancer-associated fibroblasts

  Wei, F., Uchihara, T., Yonemura, A., Yasuda-Yoshihara, N., Yasuda, T., Semba, T., Fukuda, M., Akiyama, T., Kitamura, F., Bu, L., Hu, X., Fu, L., Zhang, J., Kariya, R., Yamasaki, J., Aihara, K., Yamashita, K., Nagano, O., Okada, S., Baba, H., & 1 othersIshimoto, T., 2023 5月, In: FEBS Journal. 290, 10, p. 2604-2615 12 p.

  研究成果: Article › 査読

  • Cancer-Associated Fibroblasts 100%
  • Transgenic Mice 63%
  • Fibroblasts 53%
  • Protein 29%
  • Proteins 26%

• CD83 expression characterizes precursor exhausted T cell population

  Wu, Z., Yoshikawa, T., Inoue, S., Ito, Y., Kasuya, H., Nakashima, T., Zhang, H., Kotaka, S., Hosoda, W., Suzuki, S. & Kagoya, Y., 2023 12月, In: Communications biology. 6, 1, 258.

  研究成果: Article › 査読

  Open Access

  • T-Lymphoid Precursor Cells 100%
  • T-lymphocytes 64%
  • Antigen 58%
  • T-Lymphocytes 43%
  • Chimeric Antigen Receptors 34%
  1 被引用数 (Scopus)

• Epithelial SOX9 drives progression and metastases of gastric adenocarcinoma by promoting immunosuppressive tumour microenvironment

  Fan, Y., Li, Y., Yao, X., Jin, J., Scott, A., Liu, B., Wang, S., Huo, L., Wang, Y., Wang, R., Pool Pizzi, M., Ma, L., Shao, S., Sewastjanow-Silva, M., Waters, R., Chatterjee, D., Liu, B., Shanbhag, N., Peng, G., Calin, G. A., & 11 othersMazur, P. K., Hanash, S. M., Ishizawa, J., Hirata, Y., Nagano, O., Wang, Z., Wang, L., Xian, W., McKeon, F., Ajani, J. A. & Song, S., 2023 4月, In: Gut. 72, 4, p. 624-637 14 p.

  研究成果: Article › 査読

  • Tumor Microenvironment 100%
  • Immunosuppressive Agents 80%
  • Adenocarcinoma 75%
  • Stomach 69%
  • Neoplasm Metastasis 59%
  6 被引用数 (Scopus)

• Mesolimbic dopamine release precedes actively sought aversive stimuli in mice

  Yawata, Y., Shikano, Y., Ogasawara, J., Makino, K., Kashima, T., Ihara, K., Yoshimoto, A., Morikawa, S., Yagishita, S., Tanaka, K. F. & Ikegaya, Y., 2023 12月, In: Nature communications. 14, 1, 2433.

  研究成果: Article › 査読

  Open Access

  • self stimulation 100%
  • dopamine 81%
  • Narcotic Antagonist 78%
  • Self Stimulation 74%
  • mice 55%

• Pupil Dynamics-derived Sleep Stage Classification of a Head-fixed Mouse Using a Recurrent Neural Network

  Kobayashi, G., Tanaka, K. F. & Takata, N., 2023, In: Keio Journal of Medicine. 72, 2, p. 44-59 16 p.

  研究成果: Article › 査読

  Open Access

  • Sleep Stages 100%
  • Pupil 87%
  • Electromyography 65%
  • Head 58%
  • Electrodes 41%
  1 被引用数 (Scopus)

• Quantum Optical Tomography using a Time-Resolved and Mode-Selective Frequency-Up-Conversion Detector

  Namekata, N., Kobayashi, N., Nomura, K., Sako, T., Takata, N. & Inoue, S., 2023, 2023 Conference on Lasers and Electro-Optics Europe and European Quantum Electronics Conference, CLEO/Europe-EQEC 2023. Institute of Electrical and Electronics Engineers Inc., (2023 Conference on Lasers and Electro-Optics Europe and European Quantum Electronics Conference, CLEO/Europe-EQEC 2023).

  研究成果: Conference contribution

  • Optical tomography 100%
  • Photons 86%
  • penetration 59%
  • tomography 57%
  • Detectors 56%

• Separate optogenetic manipulation of Nerve/glial antigen 2 (NG2) glia and mural cells using the NG2 promoter

  Oishi, M., Passlick, S., Yamazaki, Y., Unekawa, M., Adachi, R., Yamada, M., Imayoshi, I., Abe, Y., Steinhäuser, C. & Tanaka, K. F., 2023 2月, In: Glia. 71, 2, p. 317-333 17 p.

  研究成果: Article › 査読

  • Optogenetics 100%
  • Neuroglia 68%
  • Antigens 48%
  • Neurons 47%
  • Trans-Activators 36%
  1 被引用数 (Scopus)

• Serotonergic neurons control cortical neuronal intracellular energy dynamics by modulating astrocyte-neuron lactate shuttle

  Natsubori, A., Hirai, S., Kwon, S., Ono, D., Deng, F., Wan, J., Miyazawa, M., Kojima, T., Okado, H., Karashima, A., Li, Y., Tanaka, K. F. & Honda, M., 2023 1月 20, In: iScience. 26, 1, 105830.

  研究成果: Article › 査読

  Open Access

  • Serotonergic Neurons 100%
  • Astrocytes 68%
  • Lactic Acid 66%
  • Neurons 45%
  • Adenosine Triphosphate 43%
  1 被引用数 (Scopus)

• Slow-rising and fast-falling dopaminergic dynamics jointly adjust negative prediction error in the ventral striatum

  Shikano, Y., Yagishita, S., Tanaka, K. F. & Takata, N., 2023, (Accepted/In press) In: European Journal of Neuroscience.

  研究成果: Article › 査読

  Open Access

  • Ventral Striatum 100%
  • Reward 72%
  • Motivation 52%
  • Photometry 15%
  • Food 15%
  3 被引用数 (Scopus)

• Starburst amacrine cells amplify optogenetic visual restoration through gap junctions

  Katada, Y., Kunimi, H., Serizawa, N., Lee, D., Kobayashi, K., Negishi, K., Okano, H., Tanaka, K. F., Tsubota, K. & Kurihara, T., 2023 9月 14, In: Molecular Therapy - Methods and Clinical Development. 30, p. 1-13 13 p.

  研究成果: Article › 査読

  Open Access

  • Amacrine Cells 100%
  • Optogenetics 96%
  • Retinal Ganglion Cells 85%
  • Gap Junctions 85%
  • Channelrhodopsins 57%

• Stromal Reprogramming through Dual PDGFRα/β Blockade Boosts the Efficacy of Anti-PD-1 Immunotherapy in Fibrotic Tumors

  Akiyama, T., Yasuda, T., Uchihara, T., Yasuda-Yoshihara, N., Tan, B. J. Y., Yonemura, A., Semba, T., Yamasaki, J., Komohara, Y., Ohnishi, K., Wei, F., Fu, L., Zhang, J., Kitamura, F., Yamashita, K., Eto, K., Iwagami, S., Tsukamoto, H., Umemoto, T., Masuda, M., & 6 othersNagano, O., Satou, Y., Saya, H., Tan, P., Baba, H. & Ishimoto, T., 2023 3月 2, In: Cancer Research. 83, 5, p. 753-770 18 p.

  研究成果: Article › 査読

  • Platelet-Derived Growth Factor beta Receptor 100%
  • Immunotherapy 64%
  • Myeloid-Derived Suppressor Cells 28%
  • Stomach Neoplasms 27%
  • Neoplasms 23%
  8 被引用数 (Scopus)
• 2022

  A gradual temporal shift of dopamine responses mirrors the progression of temporal difference error in machine learning

  Amo, R., Matias, S., Yamanaka, A., Tanaka, K. F., Uchida, N. & Watabe-Uchida, M., 2022 8月, In: Nature Neuroscience. 25, 8, p. 1082-1092 11 p.

  研究成果: Article › 査読

  • Machine Learning 100%
  • Dopamine 74%
  • Reward 36%
  • Cues 33%
  • Ventral Striatum 16%
  11 被引用数 (Scopus)

• Angiopoietin-like 4 promotes glucose metabolism by regulating glucose transporter expression in colorectal cancer

  Mizuno, S., Seishima, R., Yamasaki, J., Hattori, K., Ogiri, M., Matsui, S., Shigeta, K., Okabayashi, K., Nagano, O., Li, L. & Kitagawa, Y., 2022 6月, In: Journal of Cancer Research and Clinical Oncology. 148, 6, p. 1351-1361 11 p.

  研究成果: Article › 査読

  • Angiopoietins 100%
  • Facilitative Glucose Transport Proteins 80%
  • Colorectal Neoplasms 55%
  • Glucose 43%
  • Neoplasms 16%
  2 被引用数 (Scopus)

• Development of an in vitro carcinogenesis model of human papillomavirus-induced cervical adenocarcinoma

  Zhang, M., Kiyono, T., Aoki, K., Goshima, N., Kobayashi, S., Hiranuma, K., Shiraishi, K., Saya, H. & Nakahara, T., 2022 3月, In: Cancer science. 113, 3, p. 904-915 12 p.

  研究成果: Article › 査読

  Open Access

  • Adenocarcinoma 100%
  • Carcinogenesis 97%
  • varespladib methyl 66%
  • Uterine Cervical Neoplasms 58%
  • In Vitro Techniques 55%
  4 被引用数 (Scopus)

• Downregulation of B d nf Expression in Adult Mice Causes Body Weight Gain

  Suzuki, T. & Tanaka, K. F., 2022 9月, In: Neurochemical Research.

  研究成果: Article › 査読

  • Weight Gain 100%
  • Brain-Derived Neurotrophic Factor 83%
  • Major Depressive Disorder 82%
  • Disorder 67%
  • Body Weight 56%
  2 被引用数 (Scopus)

• Dysfunction of parvalbumin-expressing cells in the thalamic reticular nucleus induces cortical spike-and-wave discharges and an unconscious state

  Abdelaal, M. S., Midorikawa, M., Suzuki, T., Kobayashi, K., Takata, N., Miyata, M., Mimura, M. & Tanaka, K. F., 2022, In: Brain Communications. 4, 2, fcac010.

  研究成果: Article › 査読

  Open Access

  • Thalamic Nuclei 100%
  • Parvalbumins 99%
  • Unconsciousness 90%
  • Seizures 52%
  • Trans-Activators 35%
  3 被引用数 (Scopus)

• Gene therapy using genome-edited iPS cells for targeting malignant glioma

  Tamura, R., Miyoshi, H., Imaizumi, K., Yo, M., Kase, Y., Sato, T., Sato, M., Morimoto, Y., Sampetrean, O., Kohyama, J., Shinozaki, M., Miyawaki, A., Yoshida, K., Saya, H., Okano, H. & Toda, M., 2022, (Accepted/In press) In: Bioengineering and Translational Medicine.

  研究成果: Article › 査読

  Open Access

  • Gene therapy 100%
  • Stem cells 80%
  • Induced Pluripotent Stem Cells 64%
  • Neural Stem Cells 64%
  • Genomics 59%
  3 被引用数 (Scopus)

• Immune evasion and chronological decrease in titer of neutralizing antibody against SARS-CoV-2 and its variants of concerns in COVID-19 patients

  for the Keio Donner Project, 2022 5月, In: Clinical Immunology. 238, 108999.

  研究成果: Article › 査読

  Open Access

  • SARS Virus 100%
  • Immune Evasion 85%
  • Neutralizing Antibodies 67%
  • Vaccination 54%
  • Infections 32%
  8 被引用数 (Scopus)

• Lateral habenula glutamatergic neurons projecting to the dorsal raphe nucleus promote aggressive arousal in mice

  Takahashi, A., Durand-de Cuttoli, R., Flanigan, M. E., Hasegawa, E., Tsunematsu, T., Aleyasin, H., Cherasse, Y., Miya, K., Okada, T., Keino-Masu, K., Mitsui, K., Li, L., Patel, V., Blitzer, R. D., Lazarus, M., Tanaka, K. F., Yamanaka, A., Sakurai, T., Ogawa, S. & Russo, S. J., 2022 12月, In: Nature communications. 13, 1, 4039.

  研究成果: Article › 査読

  Open Access

  • arousal 100%
  • Habenula 87%
  • Dorsal Raphe Nucleus 81%
  • mice 65%
  • neurons 63%
  5 被引用数 (Scopus)

• MEK inhibition suppresses metastatic progression of KRAS-mutated gastric cancer

  Yamasaki, J., Hirata, Y., Otsuki, Y., Suina, K., Saito, Y., Masuda, K., Okazaki, S., Ishimoto, T., Saya, H. & Nagano, O., 2022 3月, In: Cancer science. 113, 3, p. 916-925 10 p.

  研究成果: Article › 査読

  Open Access

  • Mitogen-Activated Protein Kinase Kinases 100%
  • Stomach Neoplasms 79%
  • Stomach 48%
  • Organoids 32%
  • Neoplasms 29%
  5 被引用数 (Scopus)

• Mutation of PTPN11 (Encoding SHP-2) Promotes MEK Activation and Malignant Progression in Neurofibromin-Deficient Cells in a Manner Sensitive to BRAP Mutation

  Harigai, R., Sato, R., Hirose, C., Takenouchi, T., Kosaki, K., Hirose, T., Saya, H. & Arima, Y., 2022 5月 1, In: Cancers. 14, 10, 2377.

  研究成果: Article › 査読

  Open Access

  • Neurofibromin 1 100%
  • Neurofibromatosis 1 79%
  • Mitogen-Activated Protein Kinase Kinases 70%
  • Mutation 36%
  • Neurofibrosarcoma 21%

• Optogenetic stimulus-triggered acquisition of seizure resistance

  Shimoda, Y., Beppu, K., Ikoma, Y., Morizawa, Y. M., Zuguchi, S., Hino, U., Yano, R., Sugiura, Y., Moritoh, S., Fukazawa, Y., Suematsu, M., Mushiake, H., Nakasato, N., Iwasaki, M., Tanaka, K. F., Tominaga, T. & Matsui, K., 2022 2月, In: Neurobiology of Disease. 163, 105602.

  研究成果: Article › 査読

  Open Access

  • Optogenetics 100%
  • Seizures 59%
  • Adenosine 45%
  • Brain 37%
  • Astrocytes 28%
  8 被引用数 (Scopus)

• Oscillatory Population-Level Activity of Dorsal Raphe Serotonergic Neurons Is Inscribed in Sleep Structure

  Kato, T., Mitsukura, Y., Yoshida, K., Mimura, M., Takata, N. & Tanaka, K. F., 2022 9月 21, In: Journal of Neuroscience. 42, 38, p. 7244-7255 12 p.

  研究成果: Article › 査読

  Open Access

  • Serotonergic Neurons 100%
  • Dorsal Raphe Nucleus 95%
  • Serotonin 63%
  • Sleep 58%
  • Eye Movements 38%
  4 被引用数 (Scopus)

• Presence of spontaneous epithelial-mesenchymal plasticity in esophageal cancer

  Tsuchihashi, K., Hirata, Y., Yamasaki, J., Suina, K., Tanoue, K., Yae, T., Masuda, K., Baba, E., Akashi, K., Kitagawa, Y., Saya, H. & Nagano, O., 2022 7月, In: Biochemistry and Biophysics Reports. 30, 101246.

  研究成果: Article › 査読

  Open Access

  • Plastic Property 100%
  • Esophageal Neoplasms 88%
  • Protein Splicing 31%
  • Marker 25%
  • Epithelial-Mesenchymal Transition 22%
  1 被引用数 (Scopus)

• Ratio-metric measurement of intracellular calcium in visceral muscles via selective expression of a yellow cameleon calcium sensor

  Takai, C., Iwata, N., Kanemaru, K., Tanaka, K. F., Yu, Y., Iino, S. & Nakayama, S., 2022 8月 1, In: Sensors and Actuators B: Chemical. 364, 131756.

  研究成果: Article › 査読

  Open Access

  • Striated Crystal 100%
  • smooth muscle 97%
  • skeletal muscle 88%
  • Calcium 74%
  • muscles 71%

• Rhythmic activation of excitatory neurons in the mouse frontal cortex improves the prefrontal cortex-mediated cognitive function

  Hazra, D., Yoshinaga, S., Yoshida, K., Takata, N., Tanaka, K. F., Kubo, K. & Nakajima, K., 2022 11月 21, In: Cerebral cortex (New York, N.Y. : 1991). 32, 23, p. 5243-5258 16 p.

  研究成果: Article › 査読

  • Frontal Lobe 100%
  • Prefrontal Cortex 96%
  • Cognition 84%
  • Light 75%
  • Neurons 65%
  1 被引用数 (Scopus)

• Synaptic pruning through glial synapse engulfment upon motor learning

  Morizawa, Y. M., Matsumoto, M., Nakashima, Y., Endo, N., Aida, T., Ishikane, H., Beppu, K., Moritoh, S., Inada, H., Osumi, N., Shigetomi, E., Koizumi, S., Yang, G., Hirai, H., Tanaka, K., Tanaka, K. F., Ohno, N., Fukazawa, Y. & Matsui, K., 2022 11月, In: Nature Neuroscience. 25, 11, p. 1458-1469 12 p.

  研究成果: Article › 査読

  • Neuronal Plasticity 100%
  • Synapses 96%
  • Neuroglia 92%
  • Learning 76%
  • Spine 32%
  8 被引用数 (Scopus)

• The Mlc1 Promoter Directs Müller Cell-specific Gene Expression in the Retina

  Danjo, Y., Shinozaki, Y., Natsubori, A., Kubota, Y., Kashiwagi, K., Tanaka, K. F. & Koizumi, S., 2022 1月, In: Translational Vision Science and Technology. 11, 1, 25.

  研究成果: Article › 査読

  Open Access

  • Neuroglia 100%
  • yellow cameleon 80%
  • Gene expression 64%
  • Retina 50%
  • Astrocytes 40%
  2 被引用数 (Scopus)

• Tumor-specific interendothelial adhesion mediated by FLRT2 facilitates cancer aggressiveness

  Ando, T., Tai-Nagara, I., Sugiura, Y., Kusumoto, D., Okabayashi, K., Kido, Y., Sato, K., Saya, H., Navankasattusas, S., Li, D. Y., Suematsu, M., Kitagawa, Y., Seiradake, E., Yamagishi, S. & Kubota, Y., 2022 3月 15, In: Journal of Clinical Investigation. 132, 6, e153626.

  研究成果: Article › 査読

  Open Access

  • Leucine 100%
  • Fibronectins 95%
  • Proteins 35%
  • Neoplasms 31%
  • Axon Guidance 17%
  7 被引用数 (Scopus)

• Young age, female sex, and presence of systemic adverse reactions are associated with high post-vaccination antibody titer after two doses of BNT162b2 mRNA SARS-CoV-2 vaccination: An observational study of 646 Japanese healthcare workers and university staff

  for the Keio Donner Project Team, 2022 2月 11, In: Vaccine. 40, 7, p. 1019-1025 7 p.

  研究成果: Article › 査読

  Open Access

  • SARS Virus 100%
  • observational studies 87%
  • health care workers 85%
  • vaccination 75%
  • Health Personnel 58%
  30 被引用数 (Scopus)
• 2021

  Activation of ventral CA1 hippocampal neurons projecting to the lateral septum during feeding

  Kosugi, K., Yoshida, K., Suzuki, T., Kobayashi, K., Yoshida, K., Mimura, M. & Tanaka, K. F., 2021 3月, In: Hippocampus. 31, 3, p. 294-304 11 p.

  研究成果: Article › 査読

  Open Access

  • Neurons 100%
  • Food 63%
  • Feeding Behavior 52%
  • Hippocampus 43%
  • Eating 40%
  12 被引用数 (Scopus)

• A Novel Alaska Pollock Gelatin Sealant Shows Higher Bonding Strength and Nerve Regeneration Comparable to That of Fibrin Sealant in a Cadaveric Model and a Rat Model

  Masuda, S., Suzuki, T., Shibata, S., Moritoki, N., Abe, Y., Chen, X., Mizuno, Y., Nishiguchi, A., Kimura, H., Matsumura, N., Iwamoto, T., Taguchi, T., Matsumoto, M. & Nakamura, M., 2021 11月 1, In: Plastic and Reconstructive Surgery. 148, 5, p. 742E-752E

  研究成果: Article › 査読

  • Fibrin Tissue Adhesive 100%
  • Nerve Regeneration 95%
  • Gelatin 85%
  • Sutures 46%
  • Sciatic Nerve 22%

• Assessment of humoral responses in COVID-19 using various quantitative antibody tests

  Wakui, M., Uwamino, Y., Kurafuji, T., Noguchi, M., Ohno, A., Yokota, H., Kikuchi, H., Hasegawa, N., Saya, H. & Murata, M., 2021 7月, In: Annals of Clinical Biochemistry. 58, 4, p. 368-376 9 p.

  研究成果: Article › 査読

  • SARS Virus 100%
  • Antibodies 87%
  • Antigen 66%
  • Time 56%
  • Seroconversion 51%
  1 被引用数 (Scopus)

• Astrocytic cAMP modulates memory via synaptic plasticity

  Zhou, Z., Okamoto, K., Onodera, J., Hiragi, T., Andoh, M., Ikawa, M., Tanaka, K. F., Ikegaya, Y. & Koyama, R., 2021 1月 15, In: Proceedings of the National Academy of Sciences of the United States of America. 118, 3, e2016584118.

  研究成果: Article › 査読

  Open Access

  • Neuronal Plasticity 100%
  • Astrocytes 77%
  • Memory 76%
  • Animal Behavior 27%
  • Psychology Retention 23%
  37 被引用数 (Scopus)

• CD44 modulates metabolic pathways and altered ROS-mediated Akt signal promoting cholangiocarcinoma progression

  Thanee, M., Dokduang, H., Kittirat, Y., Phetcharaburanin, J., Klanrit, P., Titapun, A., Namwat, N., Khuntikeo, N., Wangwiwatsin, A., Saya, H. & Loilome, W., 2021 3月, In: PloS one. 16, 3 March, e0245871.

  研究成果: Article › 査読

  Open Access

  • Cholangiocarcinoma 100%
  • Metabolic Networks and Pathways 87%
  • Oxidation-Reduction 83%
  • Cell Migration Inhibition 62%
  • 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid 61%
  7 被引用数 (Scopus)

• Chronic social defeat stress impairs goal-directed behavior through dysregulation of ventral hippocampal activity in male mice

  Yoshida, K., Drew, M. R., Kono, A., Mimura, M., Takata, N. & Tanaka, K. F., 2021 8月, In: Neuropsychopharmacology. 46, 9, p. 1606-1616 11 p.

  研究成果: Article › 査読

  Open Access

  • Hippocampus 100%
  • Depression 82%
  • Motivation 80%
  • Photometry 36%
  • Optogenetics 32%
  11 被引用数 (Scopus)

• Clinical utility of SARS-CoV-2 whole genome sequencing in deciphering source of infection

  Keio Donner Project, 2021 1月, In: Journal of Hospital Infection. 107, p. 40-44 5 p.

  研究成果: Article › 査読

  Open Access

  • Severe Acute Respiratory Syndrome 100%
  • Coronavirus 97%
  • Whole Genome Sequencing 90%
  • Infections 37%
  • Viral Genome 29%
  16 被引用数 (Scopus)

• Compartmentalized Input–Output Organization of Lugaro Cells in the Cerebellar Cortex

  Miyazaki, T., Yamasaki, M., Tanaka, K. F. & Watanabe, M., 2021 5月 10, In: Neuroscience. 462, p. 89-105 17 p.

  研究成果: Article › 査読

  • Cerebellar Cortex 100%
  • yellow cameleon 41%
  • Interneurons 31%
  • Axons 30%
  • Purkinje Cells 28%
  13 被引用数 (Scopus)

• Comprehensive genomic analysis contrasting primary colorectal cancer and matched liver metastases

  Shiomi, A., Kusuhara, M., Sugino, T., Sugiura, T., Ohshima, K., Nagashima, T., Urakami, K., Serizawa, M., Saya, H. & Yamaguchi, K., 2021 6月, In: Oncology Letters. 21, 6, 466.

  研究成果: Article › 査読

  Open Access

  • Liver Neoplasms 100%
  • Colorectal Neoplasms 79%
  • Neoplasm Metastasis 62%
  • Liver 51%
  • thrombospondin 2 26%
  6 被引用数 (Scopus)

• Deficiency of large tumor suppressor kinase 1 causes congenital hearing loss associated with cochlear abnormalities in mice

  Nishiyama, T., Fujioka, M., Saegusa, C., Oishi, N., Harada, T., Hosoya, M., Saya, H. & Ogawa, K., 2021 1月 1, In: Biochemical and Biophysical Research Communications. 534, p. 921-926 6 p.

  研究成果: Article › 査読

  • Cochlea 100%
  • Hearing Loss 90%
  • Phosphotransferases 73%
  • Physiological Role 58%
  • Auditory Hair Cells 54%
  2 被引用数 (Scopus)

• Differential pial and penetrating arterial responses examined by optogenetic activation of astrocytes and neurons

  Hatakeyama, N., Unekawa, M., Murata, J., Tomita, Y., Suzuki, N., Nakahara, J., Takuwa, H., Kanno, I., Matsui, K., Tanaka, K. F. & Masamoto, K., 2021 10月, In: Journal of Cerebral Blood Flow and Metabolism. 41, 10, p. 2676-2689 14 p.

  研究成果: Article › 査読

  Open Access

  • Optogenetics 100%
  • Astrocytes 70%
  • Cerebrovascular Circulation 55%
  • Neurons 47%
  • Dilatation 31%
  10 被引用数 (Scopus)

• Direct impact of motor cortical stimulation on the blood oxygen-level dependent response in rats

  Xin, Z., Abe, Y., Liu, S., Tanaka, K. F., Hosomi, K., Saitoh, Y. & Sekino, M., 2021, In: Magnetic Resonance in Medical Sciences. 20, 1, p. 83-90 8 p.

  研究成果: Article › 査読

  Open Access

  • Motor Cortex 100%
  • Oxygen 70%
  • Neuralgia 29%
  • Magnetic Resonance Imaging 28%
  • Tungsten 19%
  1 被引用数 (Scopus)

• Discovery of widespread transcription initiation at microsatellites predictable by sequence-based deep neural network

  FANTOM consortium, 2021 12月 1, In: Nature communications. 12, 1, 3297.

  研究成果: Article › 査読

  Open Access

  • microsatellites 100%
  • Microsatellite Repeats 67%
  • caps 48%
  • gene expression 37%
  • Tandem Repeat Sequences 20%
  8 被引用数 (Scopus)

• Elevated cellular PpIX potentiates sonodynamic therapy in a mouse glioma stem cell-bearing glioma model by downregulating the Akt/NF-κB/MDR1 pathway

  Shono, K., Mizobuchi, Y., Yamaguchi, I., Nakajima, K., Fujiwara, Y., Fujihara, T., Kitazato, K., Matsuzaki, K., Uto, Y., Sampetrean, O., Saya, H. & Takagi, Y., 2021 12月, In: Scientific reports. 11, 1, 15105.

  研究成果: Article › 査読

  Open Access

  • protoporphyrin IX 100%
  • Glioma 69%
  • Glioblastoma 63%
  • Stem Cells 55%
  • Down-Regulation 52%
  7 被引用数 (Scopus)

• Evaluation of the usability of various rapid antibody tests in the diagnostic application for COVID-19

  for the Keio Donner Project Team, 2021 5月, In: Annals of Clinical Biochemistry. 58, 3, p. 174-180 7 p.

  研究成果: Article › 査読

  Open Access

  • Chain Reaction 100%
  • Routine Diagnostic Tests 96%
  • Severe Acute Respiratory Syndrome 74%
  • Coronavirus 73%
  • Reverse Transcription 63%
  15 被引用数 (Scopus)

• Exacerbation of epilepsy by astrocyte alkalization and gap junction uncoupling

  Onodera, M., Meyer, J., Furukawa, K., Hiraoka, Y., Aida, T., Tanaka, K., Tanaka, K. F., Rose, C. R. & Matsui, K., 2021 3月 10, In: Journal of Neuroscience. 41, 10, p. 2106-2118 13 p.

  研究成果: Article › 査読

  Open Access

  • Gap Junctions 100%
  • Astrocytes 80%
  • Epilepsy 73%
  • Seizures 20%
  • Ions 14%
  23 被引用数 (Scopus)

• Flexible annotation atlas of the mouse brain: combining and dividing brain structures of the Allen Brain Atlas while maintaining anatomical hierarchy

  Takata, N., Sato, N., Komaki, Y., Okano, H. & Tanaka, K. F., 2021 12月, In: Scientific reports. 11, 1, 6234.

  研究成果: Article › 査読

  Open Access

  • Atlases 100%
  • Brain 45%
  • Boidae 13%
  • Research Personnel 12%
  • Neuroimaging 8%
  4 被引用数 (Scopus)

• FOXO3 is a latent tumor suppressor for FOXO3-positive and cytoplasmic-type gastric cancer cells

  Tsuji, T., Maeda, Y., Kita, K., Murakami, K., Saya, H., Takemura, H., Inaki, N., Oshima, M. & Oshima, H., 2021 4月 29, In: Oncogene. 40, 17, p. 3072-3086 15 p.

  研究成果: Article › 査読

  Open Access

  • Stomach Neoplasms 100%
  • Phosphatidylinositol 3-Kinases 42%
  • Neoplasms 37%
  • Carcinogenesis 22%
  • Organoids 18%
  15 被引用数 (Scopus)

• Global knockdown of glutamate decarboxylase 67 elicits emotional abnormality in mice

  Miyata, S., Kakizaki, T., Fujihara, K., Obinata, H., Hirano, T., Nakai, J., Tanaka, M., Itohara, S., Watanabe, M., Tanaka, K. F., Abe, M., Sakimura, K. & Yanagawa, Y., 2021 12月, In: Molecular brain. 14, 1, 5.

  研究成果: Article › 査読

  Open Access

  • Glutamate Decarboxylase 100%
  • Doxycycline 30%
  • Brain 16%
  • Mental Disorders 16%
  • Startle Reflex 8%
  8 被引用数 (Scopus)