先端医科学研究所(遺伝子)

研究成果

年別の研究成果 1984 2016 2017 2018 2019 2020 2021 2023

• 177 Article
• 17 Review article
• 4 Comment/debate
• 1 Chapter
• 3 その他
  • 1 Conference contribution
  • 1 Letter
  • 1 Short survey

年別の研究成果

年別の研究成果

検索結果

• 2023

  A novel tdTomato transgenic mouse model to visualize FAP-positive cancer-associated fibroblasts

  Wei, F., Uchihara, T., Yonemura, A., Yasuda-Yoshihara, N., Yasuda, T., Semba, T., Fukuda, M., Akiyama, T., Kitamura, F., Bu, L., Hu, X., Fu, L., Zhang, J., Kariya, R., Yamasaki, J., Aihara, K., Yamashita, K., Nagano, O., Okada, S., Baba, H., & 1 othersIshimoto, T., 2023 5月, In: FEBS Journal. 290, 10, p. 2604-2615 12 p.

  研究成果: Article › 査読

  • Cancer-Associated Fibroblasts 100%
  • Transgenic Mice 63%
  • Fibroblasts 53%
  • Protein 29%
  • Proteins 26%

• Epithelial SOX9 drives progression and metastases of gastric adenocarcinoma by promoting immunosuppressive tumour microenvironment

  Fan, Y., Li, Y., Yao, X., Jin, J., Scott, A., Liu, B., Wang, S., Huo, L., Wang, Y., Wang, R., Pool Pizzi, M., Ma, L., Shao, S., Sewastjanow-Silva, M., Waters, R., Chatterjee, D., Liu, B., Shanbhag, N., Peng, G., Calin, G. A., & 11 othersMazur, P. K., Hanash, S. M., Ishizawa, J., Hirata, Y., Nagano, O., Wang, Z., Wang, L., Xian, W., McKeon, F., Ajani, J. A. & Song, S., 2023 4月, In: Gut. 72, 4, p. 624-637 14 p.

  研究成果: Article › 査読

  • Tumor Microenvironment 100%
  • Immunosuppressive Agents 80%
  • Adenocarcinoma 75%
  • Stomach 69%
  • Neoplasm Metastasis 59%
  5 被引用数 (Scopus)

• Stromal Reprogramming through Dual PDGFRα/β Blockade Boosts the Efficacy of Anti-PD-1 Immunotherapy in Fibrotic Tumors

  Akiyama, T., Yasuda, T., Uchihara, T., Yasuda-Yoshihara, N., Tan, B. J. Y., Yonemura, A., Semba, T., Yamasaki, J., Komohara, Y., Ohnishi, K., Wei, F., Fu, L., Zhang, J., Kitamura, F., Yamashita, K., Eto, K., Iwagami, S., Tsukamoto, H., Umemoto, T., Masuda, M., & 6 othersNagano, O., Satou, Y., Saya, H., Tan, P., Baba, H. & Ishimoto, T., 2023 3月 2, In: Cancer Research. 83, 5, p. 753-770 18 p.

  研究成果: Article › 査読

  • Platelet-Derived Growth Factor beta Receptor 100%
  • Immunotherapy 64%
  • Myeloid-Derived Suppressor Cells 28%
  • Stomach Neoplasms 27%
  • Neoplasms 23%
  6 被引用数 (Scopus)
• 2022

  Angiopoietin-like 4 promotes glucose metabolism by regulating glucose transporter expression in colorectal cancer

  Mizuno, S., Seishima, R., Yamasaki, J., Hattori, K., Ogiri, M., Matsui, S., Shigeta, K., Okabayashi, K., Nagano, O., Li, L. & Kitagawa, Y., 2022 6月, In: Journal of Cancer Research and Clinical Oncology. 148, 6, p. 1351-1361 11 p.

  研究成果: Article › 査読

  • Angiopoietins 100%
  • Facilitative Glucose Transport Proteins 80%
  • Colorectal Neoplasms 55%
  • Glucose 43%
  • Neoplasms 16%
  2 被引用数 (Scopus)

• Development of an in vitro carcinogenesis model of human papillomavirus-induced cervical adenocarcinoma

  Zhang, M., Kiyono, T., Aoki, K., Goshima, N., Kobayashi, S., Hiranuma, K., Shiraishi, K., Saya, H. & Nakahara, T., 2022 3月, In: Cancer science. 113, 3, p. 904-915 12 p.

  研究成果: Article › 査読

  Open Access

  • Adenocarcinoma 100%
  • Carcinogenesis 97%
  • varespladib methyl 66%
  • Uterine Cervical Neoplasms 58%
  • In Vitro Techniques 55%
  4 被引用数 (Scopus)

• Gene therapy using genome-edited iPS cells for targeting malignant glioma

  Tamura, R., Miyoshi, H., Imaizumi, K., Yo, M., Kase, Y., Sato, T., Sato, M., Morimoto, Y., Sampetrean, O., Kohyama, J., Shinozaki, M., Miyawaki, A., Yoshida, K., Saya, H., Okano, H. & Toda, M., 2022, (Accepted/In press) In: Bioengineering and Translational Medicine.

  研究成果: Article › 査読

  Open Access

  • Gene therapy 100%
  • Stem cells 80%
  • Induced Pluripotent Stem Cells 64%
  • Neural Stem Cells 64%
  • Genomics 59%
  2 被引用数 (Scopus)

• Immune evasion and chronological decrease in titer of neutralizing antibody against SARS-CoV-2 and its variants of concerns in COVID-19 patients

  for the Keio Donner Project, 2022 5月, In: Clinical Immunology. 238, 108999.

  研究成果: Article › 査読

  Open Access

  • SARS Virus 100%
  • Immune Evasion 85%
  • Neutralizing Antibodies 67%
  • Vaccination 54%
  • Infections 32%
  8 被引用数 (Scopus)

• MEK inhibition suppresses metastatic progression of KRAS-mutated gastric cancer

  Yamasaki, J., Hirata, Y., Otsuki, Y., Suina, K., Saito, Y., Masuda, K., Okazaki, S., Ishimoto, T., Saya, H. & Nagano, O., 2022 3月, In: Cancer science. 113, 3, p. 916-925 10 p.

  研究成果: Article › 査読

  Open Access

  • Mitogen-Activated Protein Kinase Kinases 100%
  • Stomach Neoplasms 79%
  • Stomach 48%
  • Organoids 32%
  • Neoplasms 29%
  5 被引用数 (Scopus)

• Mutation of PTPN11 (Encoding SHP-2) Promotes MEK Activation and Malignant Progression in Neurofibromin-Deficient Cells in a Manner Sensitive to BRAP Mutation

  Harigai, R., Sato, R., Hirose, C., Takenouchi, T., Kosaki, K., Hirose, T., Saya, H. & Arima, Y., 2022 5月 1, In: Cancers. 14, 10, 2377.

  研究成果: Article › 査読

  Open Access

  • Neurofibromin 1 100%
  • Neurofibromatosis 1 79%
  • Mitogen-Activated Protein Kinase Kinases 70%
  • Mutation 36%
  • Neurofibrosarcoma 21%

• Presence of spontaneous epithelial-mesenchymal plasticity in esophageal cancer

  Tsuchihashi, K., Hirata, Y., Yamasaki, J., Suina, K., Tanoue, K., Yae, T., Masuda, K., Baba, E., Akashi, K., Kitagawa, Y., Saya, H. & Nagano, O., 2022 7月, In: Biochemistry and Biophysics Reports. 30, 101246.

  研究成果: Article › 査読

  Open Access

  • Plastic Property 100%
  • Esophageal Neoplasms 88%
  • Protein Splicing 31%
  • Marker 25%
  • Epithelial-Mesenchymal Transition 22%
  1 被引用数 (Scopus)

• Tumor-specific interendothelial adhesion mediated by FLRT2 facilitates cancer aggressiveness

  Ando, T., Tai-Nagara, I., Sugiura, Y., Kusumoto, D., Okabayashi, K., Kido, Y., Sato, K., Saya, H., Navankasattusas, S., Li, D. Y., Suematsu, M., Kitagawa, Y., Seiradake, E., Yamagishi, S. & Kubota, Y., 2022 3月 15, In: Journal of Clinical Investigation. 132, 6, e153626.

  研究成果: Article › 査読

  Open Access

  • Leucine 100%
  • Fibronectins 95%
  • Proteins 35%
  • Neoplasms 31%
  • Axon Guidance 17%
  7 被引用数 (Scopus)

• Young age, female sex, and presence of systemic adverse reactions are associated with high post-vaccination antibody titer after two doses of BNT162b2 mRNA SARS-CoV-2 vaccination: An observational study of 646 Japanese healthcare workers and university staff

  for the Keio Donner Project Team, 2022 2月 11, In: Vaccine. 40, 7, p. 1019-1025 7 p.

  研究成果: Article › 査読

  Open Access

  • SARS Virus 100%
  • observational studies 87%
  • health care workers 85%
  • vaccination 75%
  • Health Personnel 58%
  27 被引用数 (Scopus)
• 2021

  Assessment of humoral responses in COVID-19 using various quantitative antibody tests

  Wakui, M., Uwamino, Y., Kurafuji, T., Noguchi, M., Ohno, A., Yokota, H., Kikuchi, H., Hasegawa, N., Saya, H. & Murata, M., 2021 7月, In: Annals of Clinical Biochemistry. 58, 4, p. 368-376 9 p.

  研究成果: Article › 査読

  • SARS Virus 100%
  • Antibodies 87%
  • Antigen 66%
  • Time 56%
  • Seroconversion 51%
  1 被引用数 (Scopus)

• CD44 modulates metabolic pathways and altered ROS-mediated Akt signal promoting cholangiocarcinoma progression

  Thanee, M., Dokduang, H., Kittirat, Y., Phetcharaburanin, J., Klanrit, P., Titapun, A., Namwat, N., Khuntikeo, N., Wangwiwatsin, A., Saya, H. & Loilome, W., 2021 3月, In: PloS one. 16, 3 March, e0245871.

  研究成果: Article › 査読

  Open Access

  • Cholangiocarcinoma 100%
  • Metabolic Networks and Pathways 87%
  • Oxidation-Reduction 83%
  • Cell Migration Inhibition 62%
  • 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid 61%
  7 被引用数 (Scopus)

• Clinical utility of SARS-CoV-2 whole genome sequencing in deciphering source of infection

  Keio Donner Project, 2021 1月, In: Journal of Hospital Infection. 107, p. 40-44 5 p.

  研究成果: Article › 査読

  • Severe Acute Respiratory Syndrome 100%
  • Coronavirus 97%
  • Whole Genome Sequencing 90%
  • Infections 37%
  • Viral Genome 29%
  16 被引用数 (Scopus)

• Comprehensive genomic analysis contrasting primary colorectal cancer and matched liver metastases

  Shiomi, A., Kusuhara, M., Sugino, T., Sugiura, T., Ohshima, K., Nagashima, T., Urakami, K., Serizawa, M., Saya, H. & Yamaguchi, K., 2021 6月, In: Oncology Letters. 21, 6, 466.

  研究成果: Article › 査読

  Open Access

  • Liver Neoplasms 100%
  • Colorectal Neoplasms 79%
  • Neoplasm Metastasis 62%
  • Liver 51%
  • thrombospondin 2 26%
  5 被引用数 (Scopus)

• Deficiency of large tumor suppressor kinase 1 causes congenital hearing loss associated with cochlear abnormalities in mice

  Nishiyama, T., Fujioka, M., Saegusa, C., Oishi, N., Harada, T., Hosoya, M., Saya, H. & Ogawa, K., 2021 1月 1, In: Biochemical and Biophysical Research Communications. 534, p. 921-926 6 p.

  研究成果: Article › 査読

  • Cochlea 100%
  • Hearing Loss 90%
  • Phosphotransferases 73%
  • Physiological Role 58%
  • Auditory Hair Cells 54%
  2 被引用数 (Scopus)

• Discovery of widespread transcription initiation at microsatellites predictable by sequence-based deep neural network

  FANTOM consortium, 2021 12月 1, In: Nature communications. 12, 1, 3297.

  研究成果: Article › 査読

  Open Access

  • microsatellites 100%
  • Microsatellite Repeats 67%
  • caps 48%
  • gene expression 37%
  • Tandem Repeat Sequences 20%
  6 被引用数 (Scopus)

• Elevated cellular PpIX potentiates sonodynamic therapy in a mouse glioma stem cell-bearing glioma model by downregulating the Akt/NF-κB/MDR1 pathway

  Shono, K., Mizobuchi, Y., Yamaguchi, I., Nakajima, K., Fujiwara, Y., Fujihara, T., Kitazato, K., Matsuzaki, K., Uto, Y., Sampetrean, O., Saya, H. & Takagi, Y., 2021 12月, In: Scientific reports. 11, 1, 15105.

  研究成果: Article › 査読

  Open Access

  • protoporphyrin IX 100%
  • Glioma 69%
  • Glioblastoma 63%
  • Stem Cells 55%
  • Down-Regulation 52%
  7 被引用数 (Scopus)

• Evaluation of the usability of various rapid antibody tests in the diagnostic application for COVID-19

  for the Keio Donner Project Team, 2021 5月, In: Annals of Clinical Biochemistry. 58, 3, p. 174-180 7 p.

  研究成果: Article › 査読

  Open Access

  • Chain Reaction 100%
  • Routine Diagnostic Tests 96%
  • Severe Acute Respiratory Syndrome 74%
  • Coronavirus 73%
  • Reverse Transcription 63%
  15 被引用数 (Scopus)

• FOXO3 is a latent tumor suppressor for FOXO3-positive and cytoplasmic-type gastric cancer cells

  Tsuji, T., Maeda, Y., Kita, K., Murakami, K., Saya, H., Takemura, H., Inaki, N., Oshima, M. & Oshima, H., 2021 4月 29, In: Oncogene. 40, 17, p. 3072-3086 15 p.

  研究成果: Article › 査読

  Open Access

  • Stomach Neoplasms 100%
  • Phosphatidylinositol 3-Kinases 42%
  • Neoplasms 37%
  • Carcinogenesis 22%
  • Organoids 18%
  13 被引用数 (Scopus)

• Heterogeneous Glioma Cell Invasion under Interstitial Flow Depending on Their Differentiation Status

  Namba, N., Chonan, Y., Nunokawa, T., Sampetrean, O., Saya, H. & Sudo, R., 2021 4月, In: Tissue Engineering - Part A. 27, 7-8, p. 467-478 12 p.

  研究成果: Article › 査読

  Open Access

  • Interstitial 100%
  • Cells 92%
  • Glioma 88%
  • Adhesion 87%
  • Hydrogels 82%
  6 被引用数 (Scopus)

• Incomplete humoral response including neutralizing antibodies in asymptomatic to mild COVID-19 patients in Japan

  Keio Donner Project, 2021 3月, In: Virology. 555, p. 35-43 9 p.

  研究成果: Article › 査読

  Open Access

  • Neutralizing Antibodies 100%
  • Japan 82%
  • Pandemics 42%
  • Antibodies 33%
  • SARS Virus 29%
  20 被引用数 (Scopus)

• Isolation and characterization of neural stem/progenitor cells in the subventricular zone of the naked mole-rat brain

  Yamamura, Y., Kawamura, Y., Oiwa, Y., Oka, K., Onishi, N., Saya, H. & Miura, K., 2021 12月, In: Inflammation and Regeneration. 41, 1, 31.

  研究成果: Article › 査読

  Open Access

  • Mole Rats 100%
  • Neural Stem Cells 67%
  • Lateral Ventricles 66%
  • Stem Cells 44%
  • Brain 29%
  6 被引用数 (Scopus)

• Lactate reprograms energy and lipid metabolism in glucose-deprived oxidative glioma stem cells

  Minami, N., Tanaka, K., Sasayama, T., Kohmura, E., Saya, H. & Sampetrean, O., 2021 5月, In: Metabolites. 11, 5, 325.

  研究成果: Article › 査読

  Open Access

  • Lactate 100%
  • Lipid Metabolism 95%
  • Glioma 91%
  • Energy Metabolism 89%
  • Lactic Acid 88%
  8 被引用数 (Scopus)

• Lipidomic Analyses Uncover Apoptotic and Inhibitory Effects of Pyrvinium Pamoate on Cholangiocarcinoma Cells via Mitochondrial Membrane Potential Dysfunction

  Kittirat, Y., Phetcharaburanin, J., Promraksa, B., Kulthawatsiri, T., Wangwiwatsin, A., Klanrit, P., Sangkhamanon, S., Jarearnrat, A., Thongchot, S., Mahalapbutr, P., Loilome, W., Saya, H. & Namwat, N., 2021 12月 7, In: Frontiers in Public Health. 9, 766455.

  研究成果: Article › 査読

  Open Access

  • pyrvinium 100%
  • Lipidomics 72%
  • Cholangiocarcinoma 61%
  • Mitochondrial Membrane Potential 56%
  • cancer 48%

• MEK inhibition preferentially suppresses anchorage-independent growth in osteosarcoma cells and decreases tumors in vivo

  Shimizu, T., Kimura, K., Sugihara, E., Yamaguchi-Iwai, S., Nobusue, H., Sampetrean, O., Otsuki, Y., Fukuchi, Y., Saitoh, K., Kato, K., Soga, T., Muto, A. & Saya, H., 2021 12月, In: Journal of Orthopaedic Research. 39, 12, p. 2732-2743 12 p.

  研究成果: Article › 査読

  Open Access

  • Mitogen-Activated Protein Kinase Kinases 100%
  • Osteosarcoma 96%
  • trametinib 78%
  • Growth 46%
  • Neoplasms 29%
  3 被引用数 (Scopus)

• Modulation of Nogo receptor 1 expression orchestrates myelin-associated infiltration of glioblastoma

  Hong, J. H., Kang, S., Sa, J. K., Park, G., Oh, Y. T., Kim, T. H., Yin, J., Kim, S. S., D'Angelo, F., Koo, H., You, Y., Park, S., Kwon, H. J., Kim, C. I., Ryu, H., Lin, W., Park, E. J., Kim, Y. J., Park, M. J., Kim, H., & 17 othersKim, M. S., Chung, S., Park, C. K., Park, S. H., Kang, Y. H., Kim, J. H., Saya, H., Nakano, I., Gwak, H. S., Yoo, H., Lee, J., Hur, E. M., Shi, B., Nam, D. H., Iavarone, A., Lee, S. H. & Park, J. B., 2021 2月 1, In: Brain. 144, 2, p. 636-654 19 p.

  研究成果: Article › 査読

  Open Access

  • Nogo Receptor 1 100%
  • Myelin Sheath 58%
  • Glioblastoma 56%
  • Glioma 15%
  • Nogo Receptors 13%
  13 被引用数 (Scopus)

• Molecular pathology underlying the robustness of cancer stem cells

  Yoshida, G. J. & Saya, H., 2021 6月, In: Regenerative Therapy. 17, p. 38-50 13 p.

  研究成果: Review article › 査読

  Open Access

  • Stem cells 100%
  • Molecular Pathology 80%
  • Pathology 80%
  • Neoplastic Stem Cells 75%
  • Heterogeneity 65%
  14 被引用数 (Scopus)

• N-cadherin upregulation mediates adaptive radioresistance in glioblastoma

  Osuka, S., Zhu, D., Zhang, Z., Li, C., Stackhouse, C. T., Sampetrean, O., Olson, J. J., Yancey Gillespie, G., Saya, H., Willey, C. D. & Van Meir, E. G., 2021 3月 15, In: Journal of Clinical Investigation. 131, 6, e136098.

  研究成果: Article › 査読

  Open Access

  • Cadherins 100%
  • Glioblastoma 97%
  • Glioma 78%
  • Stem Cells 72%
  • Up-Regulation 71%
  26 被引用数 (Scopus)

• Oncogenic KRAS–expressing organoids with biliary epithelial stem cell properties give rise to biliary tract cancer in mice

  Kasuga, A., Semba, T., Sato, R., Nobusue, H., Sugihara, E., Takaishi, H., Kanai, T., Saya, H. & Arima, Y., 2021 5月, In: Cancer science. 112, 5, p. 1822-1838 17 p.

  研究成果: Article › 査読

  Open Access

  • Biliary Tract Neoplasms 100%
  • Organoids 92%
  • Stem Cells 51%
  • Epithelial Cells 50%
  • Cholangiocarcinoma 40%
  7 被引用数 (Scopus)

• Pericentromeric noncoding RNA changes DNA binding of CTCF and inflammatory gene expression in senescence and cancer

  Miyata, K., Imai, Y., Hori, S., Nishio, M., Loo, T. M., Okada, R., Yang, L., Nakadai, T., Maruyama, R., Fujii, R., Ueda, K., Jiang, L., Zheng, H., Toyokuni, S., Sakata, T., Shirahige, K., Kojima, R., Nakayama, M., Oshima, M., Nagayama, S., & 5 othersSeimiya, H., Hirota, T., Saya, H., Hara, E. & Takahashi, A., 2021 8月 31, In: Proceedings of the National Academy of Sciences of the United States of America. 118, 35, e2025647118.

  研究成果: Article › 査読

  Open Access

  • Untranslated RNA 100%
  • Cellular Senescence 97%
  • Gene Expression 53%
  • DNA 49%
  • Chromatin 29%
  28 被引用数 (Scopus)

• RT-PCR screening tests for SARS-CoV-2 with saliva samples in asymptomatic people: Strategy to maintain social and economic activities while reducing the risk of spreading the virus

  Oba, J., Taniguchi, H., Sato, M., Takamatsu, R., Morikawa, S., Nakagawa, T., Takaishi, H., Saya, H., Matsuo, K. & Nishihara, H., 2021, In: Keio Journal of Medicine. 70, 2, p. 35-43 9 p.

  研究成果: Article › 査読

  Open Access

  • Severe Acute Respiratory Syndrome 100%
  • Coronavirus 97%
  • Saliva 75%
  • Economics 60%
  • Viruses 51%
  18 被引用数 (Scopus)

• Sars-cov-2 infection among medical institution faculty and healthcare workers in tokyo, japan

  Nishimura, T., Uwamino, Y., Uno, S., Kashimura, S., Shiraki, T., Kurafuji, T., Morita, M., Noguchi, M., Azegami, T., Yamada-Goto, N., Murai-Takeda, A., Yokoyama, H., Kuwabara, K., Kato, S., Matsumoto, M., Hirata, A., Iida, M., Harada, S., Ishizaka, T., Misawa, K., & 8 othersMurata, M., Saya, H., Amagai, M., Kitagawa, Y., Takeuchi, T., Mori, M., Takebayashi, T. & Hasegawa, N., 2021, In: Internal Medicine. 60, 16, p. 2569-2575 7 p.

  研究成果: Article › 査読

  Open Access

  • Tokyo 90%
  • Coronavirus 80%
  • Health Personnel 66%
  • Japan 63%
  • Dysgeusia 38%
  2 被引用数 (Scopus)

• TGFβ signaling activated by cancer-associated fibroblasts determines the histological signature of lung adenocarcinoma

  Sato, R., Imamura, K., Semba, T., Tomita, Y., Saeki, S., Ikeda, K., Komohara, Y., Suzuki, M., Sakagami, T., Saya, H. & Arima, Y., 2021 9月 15, In: Cancer Research. 81, 18, p. 4751-4765 15 p.

  研究成果: Article › 査読

  Open Access

  • Cancer-Associated Fibroblasts 100%
  • Adenocarcinoma of Lung 76%
  • Keratin-7 24%
  • Neoplasms 23%
  • Fibroblasts 13%
  16 被引用数 (Scopus)

• The inhibitor of apoptosis protein livin confers resistance to fas-mediated immune cytotoxicity in refractory lymphoma

  Sugihara, E., Hashimoto, N., Osuka, S., Shimizu, T., Ueno, S., Okazaki, S., Yaguchi, T., Kawakami, Y., Kosaki, K., Sato, T. A., Okamoto, S. & Saya, H., 2021 10月 15, In: Cancer Research. 80, 20, p. 4439-4450 12 p.

  研究成果: Article › 査読

  Open Access

  • Inhibitor of Apoptosis Proteins 100%
  • Lymphoma 60%
  • Apoptosis 36%
  • Death Domain Receptors 14%
  • Fas Ligand Protein 14%
  5 被引用数 (Scopus)

• The membrane-linked adaptor FRS2β fashions a cytokine-rich inflammatory microenvironment that promotes breast cancer carcinogenesis

  Takeuchi, Y., Kimura, N., Murayama, T., Machida, Y., Iejima, D., Nishimura, T., Terashima, M., Wang, Y., Li, M., Sakamoto, R., Yamamoto, M., Itano, N., Inoue, Y., Ito, M., Yoshida, N., Inoue, J. I., Akashi, K., Saya, H., Fujita, K., Kuroda, M., & 5 othersKitabayashi, I., Voon, D., Suzuki, T., Tojo, A. & Gotoh, N., 2021 10月 26, In: Proceedings of the National Academy of Sciences of the United States of America. 118, 43, e2103658118.

  研究成果: Article › 査読

  Open Access

  • Mouse mammary tumor virus 100%
  • Carcinogenesis 82%
  • Breast Neoplasms 69%
  • Cytokines 67%
  • Membranes 64%
  4 被引用数 (Scopus)
• 2020

  2-Nitroimidazoles induce mitochondrial stress and ferroptosis in glioma stem cells residing in a hypoxic niche

  Koike, N., Kota, R., Naito, Y., Hayakawa, N., Matsuura, T., Hishiki, T., Onishi, N., Fukada, J., Suematsu, M., Shigematsu, N., Saya, H. & Sampetrean, O., 2020 12月 1, In: Communications biology. 3, 1, 450.

  研究成果: Article › 査読

  Open Access

  • Doranidazole 100%
  • azomycin 69%
  • 2-Nitroimidazole 65%
  • Ferroptosis 65%
  • nitroimidazoles 64%
  21 被引用数 (Scopus)

• Antifungal agent luliconazole inhibits the growth of mouse glioma-initiating cells in brain explants

  Nagashima, H., Koike, N., Yoshida, K., Saya, H. & Sampetrean, O., 2020, In: Keio Journal of Medicine. 69, 4, p. 97-104 8 p.

  研究成果: Article › 査読

  Open Access

  • luliconazole 100%
  • Antifungal Agents 60%
  • Glioma 47%
  • Growth 26%
  • Brain 25%
  1 被引用数 (Scopus)

• A potent blood–brain barrier-permeable mutant IDH1 inhibitor suppresses the growth of glioblastoma with IDH1 mutation in a patient-derived orthotopic xenograft model

  Machida, Y., Nakagawa, M., Matsunaga, H., Yamaguchi, M., Ogawara, Y., Shima, Y., Yamagata, K., Katsumoto, T., Hattori, A., Itoh, M., Seki, T., Nishiya, Y., Nakamura, K., Suzuki, K., Imaoka, T., Baba, D., Suzuki, M., Sampetrean, O., Saya, H., Ichimura, K., & 1 othersKitabayashi, I., 2020 2月, In: Molecular cancer therapeutics. 19, 2, p. 375-383 9 p.

  研究成果: Article › 査読

  • Growth Inhibitors 100%
  • Isocitrate Dehydrogenase 83%
  • Glioblastoma 75%
  • Glioma 70%
  • Heterografts 68%
  20 被引用数 (Scopus)

• Author Correction: CD44 variant inhibits insulin secretion in pancreatic β cells by attenuating LAT1-mediated amino acid uptake (Scientific Reports, (2018), 8, 1, (2785), 10.1038/s41598-018-20973-2)

  Kobayashi, N., Okazaki, S., Sampetrean, O., Irie, J., Itoh, H. & Saya, H., 2020 12月 1, In: Scientific reports. 10, 1, 6084.

  研究成果: Comment/debate › 査読

  Open Access

  • Insulin Secretion 100%
  • Amino Acids 70%
  1 被引用数 (Scopus)

• Blood and lymphatic systems are segregated by the FLCN tumor suppressor

  Tai-Nagara, I., Hasumi, Y., Kusumoto, D., Hasumi, H., Okabe, K., Ando, T., Matsuzaki, F., Itoh, F., Saya, H., Liu, C., Li, W., Mukouyama, Y. S., Marston Linehan, W., Liu, X., Hirashima, M., Suzuki, Y., Funasaki, S., Satou, Y., Furuya, M., Baba, M., & 1 othersKubota, Y., 2020 12月, In: Nature communications. 11, 1, 6314.

  研究成果: Article › 査読

  Open Access

  • lymphatic system 100%
  • suppressors 99%
  • Lymphatic System 89%
  • Lymphatic Vessels 83%
  • Plastic Property 80%
  10 被引用数 (Scopus)

• Downregulation of PD-L1 via FKBP5 by celecoxib augments antitumor effects of PD-1 blockade in a malignant glioma model

  Yamaguchi, I., Nakajima, K., Shono, K., Mizobuchi, Y., Fujihara, T., Shikata, E., Yamaguchi, T., Kitazato, K., Sampetrean, O., Saya, H. & Takagi, Y., 2020 1月 1, In: Neuro-Oncology Advances. 2, 1, vdz058.

  研究成果: Article › 査読

  Open Access

  • tacrolimus binding protein 5 100%
  • Celecoxib 67%
  • Glioma 49%
  • Ligands 37%
  • Down-Regulation 37%
  12 被引用数 (Scopus)

• Downregulation of the CCL2/CCR2 and CXCL10/CXCR3 axes contributes to antitumor effects in a mouse model of malignant glioma

  Shono, K., Yamaguchi, I., Mizobuchi, Y., Kagusa, H., Sumi, A., Fujihara, T., Nakajima, K., Kitazato, K. T., Matsuzaki, K., Saya, H. & Takagi, Y., 2020 12月 1, In: Scientific reports. 10, 1, 15286.

  研究成果: Article › 査読

  Open Access

  • CC Chemokines 100%
  • Glioma 72%
  • Ligands 55%
  • Down-Regulation 55%
  • Celecoxib 54%
  26 被引用数 (Scopus)

• Gene Therapy Using Neural Stem/Progenitor Cells Derived from Human Induced Pluripotent Stem Cells: Visualization of Migration and Bystander Killing Effect

  Tamura, R., Miyoshi, H., Morimoto, Y., Oishi, Y., Sampetrean, O., Iwasawa, C., Mine, Y., Saya, H., Yoshida, K., Okano, H. & Toda, M., 2020 3月, In: Human Gene Therapy. 31, 5-6, p. 352-366 15 p.

  研究成果: Article › 査読

  Open Access

  • Bystander Effect 100%
  • Induced Pluripotent Stem Cells 81%
  • Neural Stem Cells 80%
  • Thymidine Kinase 72%
  • Glioblastoma 70%
  16 被引用数 (Scopus)

• Identification of kit-ligand a as the gene responsible for the medaka pigment cell mutant few melanophore

  Otsuki, Y., Okuda, Y., Naruse, K. & Saya, H., 2020 1月 1, In: G3: Genes, Genomes, Genetics. 10, 1, p. 311-319 9 p.

  研究成果: Article › 査読

  Open Access

  • Melanophores 100%
  • Oryzias 92%
  • Stem Cell Factor 76%
  • Genes 25%
  • Piebaldism 15%
  6 被引用数 (Scopus)

• Lung adenocarcinoma mouse models based on orthotopic transplantation of syngeneic tumor-initiating cells expressing EpCAM, SCA-1, and Ly6d

  Semba, T., Sato, R., Kasuga, A., Suina, K., Shibata, T., Kohno, T., Suzuki, M., Saya, H. & Arima, Y., 2020 12月, In: Cancers. 12, 12, p. 1-18 18 p., 3805.

  研究成果: Article › 査読

  Open Access

  • Isogeneic Transplantation 100%
  • Epithelial Cell Adhesion Molecule 92%
  • Adenocarcinoma of Lung 71%
  • Neoplastic Stem Cells 70%
  • Organoids 52%
  7 被引用数 (Scopus)

• Molecular and cellular mechanisms underlying brain metastasis of breast cancer

  Hosonaga, M., Saya, H. & Arima, Y., 2020 9月 1, In: Cancer and Metastasis Reviews. 39, 3, p. 711-720 10 p.

  研究成果: Review article › 査読

  Open Access

  • Breast Neoplasms 100%
  • Neoplasm Metastasis 96%
  • Cellular Microenvironment 78%
  • Brain 76%
  • Triple Negative Breast Neoplasms 37%
  63 被引用数 (Scopus)

• Overexpression of a panel of cancer stem cell markers enhances the predictive capability of the progression and recurrence in the early stage cholangiocarcinoma

  Padthaisong, S., Thanee, M., Namwat, N., Phetcharaburanin, J., Klanrit, P., Khuntikeo, N., Titapun, A., Sungkhamanon, S., Saya, H. & Loilome, W., 2020 2月 10, In: Journal of Translational Medicine. 18, 1, 64.

  研究成果: Article › 査読

  Open Access

  • Cell Marker 100%
  • Cholangiocarcinoma 70%
  • Neoplastic Stem Cells 65%
  • Molecular Cluster 39%
  • Recurrence 35%
  13 被引用数 (Scopus)

• Phosphorylation of the Anaphase Promoting Complex activator FZR1/CDH1 is required for Meiosis II entry in mouse male germ cell

  Tanno, N., Kuninaka, S., Fujimura, S., Takemoto, K., Okamura, K., Takeda, N., Araki, K., Araki, M., Saya, H. & Ishiguro, K. I., 2020 12月 1, In: Scientific reports. 10, 1, 10094.

  研究成果: Article › 査読

  Open Access

  • Anaphase-Promoting Complex-Cyclosome 100%
  • Meiosis 78%
  • Germ Cells 67%
  • Phosphorylation 46%
  • Cell Cycle 15%
  7 被引用数 (Scopus)