坂口光洋記念講座

2022

Colon tumour cell death causes mTOR dependence by paracrine P2X4 stimulation

Schmitt, M., Ceteci, F., Gupta, J., Pesic, M., Böttger, T. W., Nicolas, A. M., Kennel, K. B., Engel, E., Schewe, M., Callak Kirisözü, A., Petrocelli, V., Dabiri, Y., Varga, J., Ramakrishnan, M., Karimova, M., Ablasser, A., Sato, T., Arkan, M. C., de Sauvage, F. J. & Greten, F. R., 2022 12月 8, In: Nature. 612, 7939, p. 347-353 7 p.

研究成果: Article › 査読

15 被引用数 (Scopus)

Intestinal epithelial organoids: regeneration and maintenance of the intestinal epithelium

Oda, M., Hatano, Y. & Sato, T., 2022 10月, In: Current Opinion in Genetics and Development. 76, 101977.

研究成果: Review article › 査読

2 被引用数 (Scopus)

In Vivo Intestinal Research Using Organoid Transplantation

Sugimoto, S., Kobayashi, E., Kanai, T. & Sato, T., 2022, In: Keio Journal of Medicine. 71, 4, p. 73-81 9 p.

研究成果: Article › 査読

Open Access

2 被引用数 (Scopus)

Microfluidic Device to Manipulate 3D Human Epithelial Cell-Derived Intestinal Organoids

Matsumoto, M., Morimoto, Y., Sato, T. & Takeuchi, S., 2022 12月, In: Micromachines. 13, 12, 2082.

研究成果: Article › 査読

Open Access

Organoid Medicine for Inflammatory Bowel Disease

Wakisaka, Y., Sugimoto, S. & Sato, T., 2022 2月, In: Stem Cells. 40, 2, p. 123-132 10 p.

研究成果: Review article › 査読

6 被引用数 (Scopus)

Organoid screening reveals epigenetic vulnerabilities in human colorectal cancer

Toshimitsu, K., Takano, A., Fujii, M., Togasaki, K., Matano, M., Takahashi, S., Kanai, T. & Sato, T., 2022 6月, In: Nature Chemical Biology. 18, 6, p. 605-614 10 p.

研究成果: Article › 査読

15 被引用数 (Scopus)

Organoid vs In Vivo Mouse Model: Which is Better Research Tool to Understand the Biologic Mechanisms of Intestinal Epithelium?

Sugimoto, S. & Sato, T., 2022 1月, In: CMGH. 13, 1, p. 195-197 3 p.

研究成果: Comment/debate › 査読

Open Access

10 被引用数 (Scopus)

2021

Analysis of risk factors for immune-related adverse events in various solid tumors using real-world data

Shimozaki, K., Sukawa, Y., Sato, Y., Horie, S., Chida, A., Tsugaru, K., Togasaki, K., Kawasaki, K., Hirata, K., Hayashi, H., Hamamoto, Y. & Kanai, T., 2021 7月, In: Future Oncology. 17, 20, p. 2593-2603 11 p.

研究成果: Article › 査読

Open Access

8 被引用数 (Scopus)

An organoid-based organ-repurposing approach to treat short bowel syndrome

Sugimoto, S., Kobayashi, E., Fujii, M., Ohta, Y., Arai, K., Matano, M., Ishikawa, K., Miyamoto, K., Toshimitsu, K., Takahashi, S., Nanki, K., Hakamata, Y., Kanai, T. & Sato, T., 2021 4月 1, In: Nature. 592, 7852, p. 99-104 6 p.

研究成果: Article › 査読

71 被引用数 (Scopus)

COVID-19 reinfection: A rapid systematic review of case reports and case series

Wang, J., Kaperak, C., Sato, T. & Sakuraba, A., 2021 8月 1, In: Journal of Investigative Medicine. 69, 6, p. 1253-1255 3 p.

研究成果: Review article › 査読

69 被引用数 (Scopus)

Demarcated redness associated with increased vascular density/size: A useful marker of flat-type dysplasia in patients with ulcerative colitis

Ikebata, A., Shimoda, M., Okabayashi, K., Uraoka, T., Maehata, T., Sugimoto, S., Mutaguchi, M., Naganuma, M., Kameyama, K., Yahagi, N., Kanai, T., Kitagawa, Y., Kanai, Y. & Iwao, Y., 2021 4月 1, In: Endoscopy International Open. 9, 4, p. E552-E561

研究成果: Article › 査読

Open Access

Meiosis-specific ZFP541 repressor complex promotes developmental progression of meiotic prophase towards completion during mouse spermatogenesis

Horisawa-Takada, Y., Kodera, C., Takemoto, K., Sakashita, A., Horisawa, K., Maeda, R., Shimada, R., Usuki, S., Fujimura, S., Tani, N., Matsuura, K., Akiyama, T., Suzuki, A., Niwa, H., Tachibana, M., Ohba, T., Katabuchi, H., Namekawa, S. H., Araki, K. & Ishiguro, K. I., 2021 12月 1, In: Nature communications. 12, 1, 3184.

研究成果: Article › 査読

Open Access

12 被引用数 (Scopus)

Phenotypic screening system using three-dimensional (3D) culture models for natural product screening

Suenaga, H., Kagaya, N., Kawada, M., Tatsuda, D., Sato, T. & Shin-ya, K., 2021 10月, In: Journal of Antibiotics. 74, 10, p. 660-666 7 p.

研究成果: Review article › 査読

1 被引用数 (Scopus)

Somatic cell-derived organoids as prototypes of human epithelial tissues and diseases

Fujii, M. & Sato, T., 2021 2月, In: Nature Materials. 20, 2, p. 156-169 14 p.

研究成果: Review article › 査読

Open Access

81 被引用数 (Scopus)

Synthetic mRNA-based differentiation method enables early detection of Parkinson's phenotypes in neurons derived from Gaucher disease-induced pluripotent stem cells

Akiyama, T., Sato, S., Ko, S. B. H., Sano, O., Sato, S., Saito, M., Nagai, H., Ko, M. S. H. & Iwata, H., 2021 4月, In: Stem Cells Translational Medicine. 10, 4, p. 572-581 10 p.

研究成果: Article › 査読

Open Access

7 被引用数 (Scopus)

Unbiased, comprehensive analysis of Japanese health checkup data reveals a protective effect of light to moderate alcohol consumption on lung function

Makino, K., Shimizu-Hirota, R., Goda, N., Hashimoto, M., Kawada, I., Kashiwagi, K., Hirota, Y., Itoh, H., Jinzaki, M., Iwao, Y., Ko, M., Ko, S. & Takaishi, H., 2021 12月, In: Scientific reports. 11, 1, 15954.

研究成果: Article › 査読

Open Access

Wnt Signaling Shapes the Histologic Variation in Diffuse Gastric Cancer

Togasaki, K., Sugimoto, S., Ohta, Y., Nanki, K., Matano, M., Takahashi, S., Fujii, M., Kanai, T. & Sato, T., 2021 2月, In: Gastroenterology. 160, 3, p. 823-830 8 p.

研究成果: Short survey › 査読

Open Access

32 被引用数 (Scopus)

2020

A microfluidic organoid trapping device to form tube-like intestinal organoids

Matsumoto, M., Morimoto, Y., Sato, T. & Takeuchi, S., 2020, MicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences. Chemical and Biological Microsystems Society, p. 871-872 2 p. (MicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences).

研究成果: Conference contribution

Characterization of radioresistant epithelial stem cell heterogeneity in the damaged mouse intestine

Sato, T., Sase, M., Ishikawa, S., Kajita, M., Asano, J., Sato, T., Mori, Y. & Ohteki, T., 2020 12月 1, In: Scientific reports. 10, 1, 8308.

研究成果: Article › 査読

Open Access

11 被引用数 (Scopus)

Chromosome Engineering of Human Colon-Derived Organoids to Develop a Model of Traditional Serrated Adenoma

Kawasaki, K., Fujii, M., Sugimoto, S., Ishikawa, K., Matano, M., Ohta, Y., Toshimitsu, K., Takahashi, S., Hosoe, N., Sekine, S., Kanai, T. & Sato, T., 2020 2月, In: Gastroenterology. 158, 3, p. 638-651.e8

研究成果: Article › 査読

44 被引用数 (Scopus)

Fatty Acid Synthesis Is Indispensable for Survival of Human Pluripotent Stem Cells

Tanosaki, S., Tohyama, S., Fujita, J., Someya, S., Hishiki, T., Matsuura, T., Nakanishi, H., Ohto-Nakanishi, T., Akiyama, T., Morita, Y., Kishino, Y., Okada, M., Tani, H., Soma, Y., Nakajima, K., Kanazawa, H., Sugimoto, M., Ko, M., Suematsu, M. & Fukuda, K., 2020 9月 25, In: iScience. 23, 9, 101535.

研究成果: Article › 査読

Open Access

38 被引用数 (Scopus)

Generation and Profiling of 2,135 Human ESC Lines for the Systematic Analyses of Cell States Perturbed by Inducing Single Transcription Factors

Nakatake, Y., Ko, S. B. H., Sharov, A. A., Wakabayashi, S., Murakami, M., Sakota, M., Chikazawa, N., Ookura, C., Sato, S., Ito, N., Ishikawa-Hirayama, M., Mak, S. S., Jakt, L. M., Ueno, T., Hiratsuka, K., Matsushita, M., Goparaju, S. K., Akiyama, T., Ishiguro, K. I., Oda, M., & 7 othersGouda, N., Umezawa, A., Akutsu, H., Nishimura, K., Matoba, R., Ohara, O. & Ko, M. S. H., 2020 5月 19, In: Cell Reports. 31, 7, 107655.

研究成果: Article › 査読

Open Access

17 被引用数 (Scopus)

Linking human intestinal scaffolds and organoids to combat intestinal failure

Fujii, M., Sugimoto, S. & Sato, T., 2020 10月 1, In: Nature medicine. 26, 10, p. 1517-1518 2 p.

研究成果: Comment/debate › 査読

3 被引用数 (Scopus)

MEIOSIN Directs the Switch from Mitosis to Meiosis in Mammalian Germ Cells

Ishiguro, K. I., Matsuura, K., Tani, N., Takeda, N., Usuki, S., Yamane, M., Sugimoto, M., Fujimura, S., Hosokawa, M., Chuma, S., Ko, M. S. H., Araki, K. & Niwa, H., 2020 2月 24, In: Developmental Cell. 52, 4, p. 429-445.e10

研究成果: Article › 査読

Open Access

82 被引用数 (Scopus)

Multiple immune-related adverse events and anti-tumor efficacy: Real-world data on various solid tumors

Shimozaki, K., Sukawa, Y., Beppu, N., Kurihara, I., Suzuki, S., Mizuno, R., Funakoshi, T., Ikemura, S., Tsugaru, K., Togasaki, K., Kawasaki, K., Hirata, K., Hayashi, H., Hamamoto, Y., Takaishi, H. & Kanai, T., 2020, In: Cancer Management and Research. 12, p. 4585-4593 9 p.

研究成果: Article › 査読

Open Access

29 被引用数 (Scopus)

Of infliximab with long-term administration in Japanese patients with Crohn's disease: Analysis using population pharmacokinetics

Matsuoka, K., Hamada, S., Shimizu, M., Nanki, K., Mizuno, S., Kiyohara, H., Arai, M., Sugimoto, S., Iwao, Y., Ogata, H., Hisamatsu, T., Nagauma, M., Kanai, T., Mochizuki, M. & Hashiguchi, M., 2020, In: International journal of clinical pharmacology and therapeutics. 58, 2, p. 89-102 14 p.

研究成果: Article › 査読

7 被引用数 (Scopus)

Organoid derivation and orthotopic xenotransplantation for studying human intestinal stem cell dynamics

Sugimoto, S., Fujii, M. & Sato, T., 2020, Methods in Molecular Biology. Humana Press Inc., p. 303-320 18 p. (Methods in Molecular Biology; vol. 2171).

研究成果: Chapter

6 被引用数 (Scopus)

Racial disparities in COVID-19 deaths reveal harsh truths about structural inequality in America

Anyane-Yeboa, A., Sato, T. & Sakuraba, A., 2020 10月 1, In: Journal of Internal Medicine. 288, 4, p. 479-480 2 p.

研究成果: Letter › 査読

Open Access

55 被引用数 (Scopus)

Regulated IFN signalling preserves the stemness of intestinal stem cells by restricting differentiation into secretory-cell lineages

Sato, T., Ishikawa, S., Asano, J., Yamamoto, H., Fujii, M., Sato, T., Yamamoto, K., Kitagaki, K., Akashi, T., Okamoto, R. & Ohteki, T., 2020 8月 1, In: Nature Cell Biology. 22, 8, p. 919-926 8 p.

研究成果: Article › 査読

14 被引用数 (Scopus)

2019

Cnnm4 deficiency suppresses Ca²⁺ signaling and promotes cell proliferation in the colon epithelia

Yamazaki, D., Hasegawa, A., Funato, Y., Tran, H. N., Mori, M. X., Mori, Y., Sato, T. & Miki, H., 2019 5月 16, In: Oncogene. 38, 20, p. 3962-3969 8 p.

研究成果: Article › 査読

12 被引用数 (Scopus)

Difference in the clinical characteristic and prognosis of colitis-associated cancer and sporadic neoplasia in ulcerative colitis patients

Mutaguchi, M., Naganuma, M., Sugimoto, S., Fukuda, T., Nanki, K., Mizuno, S., Hosoe, N., Shimoda, M., Ogata, H., Iwao, Y. & Kanai, T., 2019 9月, In: Digestive and Liver Disease. 51, 9, p. 1257-1264 8 p.

研究成果: Article › 査読

10 被引用数 (Scopus)

Induced Pluripotent Stem Cells Reprogrammed with Three Inhibitors Show Accelerated Differentiation Potentials with High Levels of 2-Cell Stage Marker Expression

Nishihara, K., Shiga, T., Nakamura, E., Akiyama, T., Sasaki, T., Suzuki, S., Ko, M. S. H., Tada, N., Okano, H. & Akamatsu, W., 2019 2月 12, In: Stem cell reports. 12, 2, p. 305-318 14 p.

研究成果: Article › 査読

Open Access

8 被引用数 (Scopus)

Induction of human pluripotent stem cells into kidney tissues by synthetic mRNAs encoding transcription factors

Hiratsuka, K., Monkawa, T., Akiyama, T., Nakatake, Y., Oda, M., Goparaju, S. K., Kimura, H., Chikazawa-Nohtomi, N., Sato, S., Ishiguro, K., Yamaguchi, S., Suzuki, S., Morizane, R., Ko, S., Itoh, H. & Ko, M., 2019 12月 1, In: Scientific reports. 9, 1, 913.

研究成果: Article › 査読

Open Access

32 被引用数 (Scopus)

Intramucosal poorly differentiated and signet-ring cell components in patients with ulcerative colitis-associated high-grade dysplasia

Sugimoto, S., Shimoda, M., Iwao, Y., Mutaguchi, M., Nanki, K., Mizuno, S., Kameyama, K., Ogata, H., Naganuma, M. & Kanai, T., 2019 11月 1, In: Digestive Endoscopy. 31, 6, p. 706-711 6 p.

研究成果: Article › 査読

6 被引用数 (Scopus)

In vitro modeling of the bipolar disorder and schizophrenia using patient-derived induced pluripotent stem cells with copy number variations of PCDH15 and RELN

Ishii, T., Ishikawa, M., Fujimori, K., Maeda, T., Kushima, I., Arioka, Y., Mori, D., Nakatake, Y., Yamagata, B., Nio, S., Kato, T. A., Yang, N., Wernig, M., Kanba, S., Mimura, M., Ozaki, N. & Okano, H., 2019, In: eNeuro. 6, 5, ENEURO.0403-18.2019.

研究成果: Article › 査読

Open Access

37 被引用数 (Scopus)

Long-term effect of NUDT15 R139C on hematologic indices in inflammatory bowel disease patients treated with thiopurine

Akiyama, S., Matsuoka, K., Fukuda, K., Hamada, S., Shimizu, M., Nanki, K., Mizuno, S., Kiyohara, H., Arai, M., Sugimoto, S., Iwao, Y., Ogata, H., Hisamatsu, T., Naganuma, M., Motobayashi, M., Suzuki, K., Takenaka, K., Fujii, T., Saito, E., Nagahori, M., & 5 othersOhtsuka, K., Mochizuki, M., Watanabe, M., Hashiguchi, M. & Kanai, T., 2019 10月 1, In: Journal of Gastroenterology and Hepatology (Australia). 34, 10, p. 1751-1757 7 p.

研究成果: Article › 査読

9 被引用数 (Scopus)

Modeling Human Digestive Diseases With CRISPR-Cas9–Modified Organoids

Fujii, M., Clevers, H. & Sato, T., 2019 2月, In: Gastroenterology. 156, 3, p. 562-576 15 p.

研究成果: Review article › 査読

Open Access

82 被引用数 (Scopus)

Perturbation of the titin/MURF1 signaling complex is associated with hypertrophic cardiomyopathy in a fish model and in human patients

Higashikuse, Y., Mittal, N., Arimura, T., Yoon, S. H., Oda, M., Enomoto, H., Kaneda, R., Hattori, F., Suzuki, T., Kawakami, A., Gasch, A., Furukawa, T., Labeit, S., Fukuda, K., Kimura, A. & Makino, S., 2019, In: DMM Disease Models and Mechanisms. 12, 11, dmm.041103.

研究成果: Article › 査読

Open Access

8 被引用数 (Scopus)

2018

Advancing Intestinal Organoid Technology Toward Regenerative Medicine

Nakamura, T. & Sato, T., 2018, In: CMGH. 5, 1, p. 51-60 10 p.

研究成果: Review article › 査読

82 被引用数 (Scopus)

Clinical efficacy of immune checkpoint inhibitors in the treatment of unresectable advanced or recurrent gastric cancer: An evidence-based review of therapies

Togasaki, K., Sukawa, Y., Kanai, T. & Takaishi, H., 2018, In: OncoTargets and Therapy. 11, p. 8239-8250 12 p.

研究成果: Review article › 査読

Open Access

29 被引用数 (Scopus)

Efficient differentiation of human pluripotent stem cells into skeletal muscle cells by combining RNA-based MYOD1-expression and POU5F1-silencing

Akiyama, T., Sato, S., Chikazawa-Nohtomi, N., Soma, A., Kimura, H., Wakabayashi, S., Ko, S. B. H. & Ko, M. S. H., 2018 12月 1, In: Scientific reports. 8, 1, 1189.

研究成果: Article › 査読

Open Access

20 被引用数 (Scopus)

Erratum to: Efficient genetic engineering of human intestinal organoids using electroporation (Nature Protocols, (2015), 10, 10, (1474-1485), 10.1038/nprot.2015.088)

Fujii, M., Matano, M., Nanki, K. & Sato, T., 2018 1月 1, (Accepted/In press) In: Nature Protocols.

研究成果: Article › 査読

2 被引用数 (Scopus)

Establishment of a rapid and footprint-free protocol for differentiation of human embryonic stem cells into pancreatic endocrine cells with synthetic mRNAs encoding transcription factors 10 Technology 1004 Medical Biotechnology

Ida, H., Akiyama, T., Ishiguro, K., Goparaju, S. K., Nakatake, Y., Chikazawa-Nohtomi, N., Sato, S., Kimura, H., Yokoyama, Y., Nagino, M., Ko, M. S. H. & Ko, S. B. H., 2018 10月 25, In: Stem Cell Research and Therapy. 9, 1, 277.

研究成果: Article › 査読

Open Access

10 被引用数 (Scopus)

Factors predicting the therapeutic response to infliximab during maintenance therapy in Japanese patients with Crohn's disease

Matsuoka, K., Hamada, S., Shimizu, M., Nanki, K., Mizuno, S., Kiyohara, H., Arai, M., Sugimoto, S., Iwao, Y., Ogata, H., Hisamatsu, T., Naganuma, M., Kanai, T., Mochizuki, M. & Hashiguchi, M., 2018 10月, In: PloS one. 13, 10, e0204632.

研究成果: Article › 査読

15 被引用数 (Scopus)

Post-progression survival following second-line chemotherapy in patients with advanced pancreatic cancer previously treated with gemcitabine: a meta-analysis

Kasuga, A., Hamamoto, Y., Takeuchi, A., Okano, N., Togasaki, K., Aoki, Y., Suzuki, T., Kawasaki, K., Hirata, K., Sukawa, Y., Kanai, T. & Takaishi, H., 2018 10月 1, In: Investigational new drugs. 36, 5, p. 939-948 10 p.

研究成果: Review article › 査読

6 被引用数 (Scopus)

Reconstruction of the Human Colon Epithelium In Vivo

Sugimoto, S., Ohta, Y., Fujii, M., Matano, M., Shimokawa, M., Nanki, K., Date, S., Nishikori, S., Nakazato, Y., Nakamura, T., Kanai, T. & Sato, T., 2018 2月 1, In: Cell stem cell. 22, 2, p. 171-176.e5

研究成果: Article › 査読

124 被引用数 (Scopus)

The pathogenesis linked to coenzyme Q10 insufficiency in iPSC-derived neurons from patients with multiple-system atrophy

Nakamoto, F. K., Okamoto, S., Mitsui, J., Sone, T., Ishikawa, M., Yamamoto, Y., Kanegae, Y., Nakatake, Y., Imaizumi, K., Ishiura, H., Tsuji, S. & Okano, H., 2018 12月 1, In: Scientific reports. 8, 1, 14215.

研究成果: Article › 査読

Open Access

40 被引用数 (Scopus)

2017

Bicarbonate-rich fluid secretion predicted by a computational model of guinea-pig pancreatic duct epithelium

Yamaguchi, M., Steward, M. C., Smallbone, K., Sohma, Y., Yamamoto, A., Ko, S. B. H., Kondo, T. & Ishiguro, H., 2017 3月 15, In: Journal of Physiology. 595, 6, p. 1947-1972 26 p.

研究成果: Article › 査読

Open Access

19 被引用数 (Scopus)

Cell competition with normal epithelial cells promotes apical extrusion of transformed cells through metabolic changes

Kon, S., Ishibashi, K., Katoh, H., Kitamoto, S., Shirai, T., Tanaka, S., Kajita, M., Ishikawa, S., Yamauchi, H., Yako, Y., Kamasaki, T., Matsumoto, T., Watanabe, H., Egami, R., Sasaki, A., Nishikawa, A., Kameda, I., Maruyama, T., Narumi, R., Morita, T., & 19 othersSasaki, Y., Enoki, R., Honma, S., Imamura, H., Oshima, M., Soga, T., Miyazaki, J. I., Duchen, M. R., Nam, J. M., Onodera, Y., Yoshioka, S., Kikuta, J., Ishii, M., Imajo, M., Nishida, E., Fujioka, Y., Ohba, Y., Sato, T. & Fujita, Y., 2017 5月 1, In: Nature Cell Biology. 19, 5, p. 530-541 12 p.

研究成果: Article › 査読

137 被引用数 (Scopus)

Defining the role of Lgr5⁺ stem cells in colorectal cancer: From basic research to clinical applications

Fujii, M. & Sato, T., 2017 7月 18, In: Genome Medicine. 9, 1, 66.

研究成果: Comment/debate › 査読

7 被引用数 (Scopus)

坂口光洋記念講座

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