薬学科

2023

Aberrant accumulation of NIK promotes tumor growth by dysregulating translation and post-translational modifications in breast cancer

Hayashi, Y., Nakayama, J., Yamamoto, M., Maekawa, M., Watanabe, S., Higashiyama, S., Inoue, J. I., Yamamoto, Y. & Semba, K., 2023 12月, In: Cancer Cell International. 23, 1, 57.

研究成果: Article › 査読

Open Access

A combination of 5/6-nephrectomy and unilateral ureteral obstruction model accelerates progression of remote organ fibrosis in chronic kidney disease

Homma, K., Enoki, Y., Uchida, S., Taguchi, K. & Matsumoto, K., 2023 10月, In: FASEB BioAdvances. 5, 10, p. 377-394 18 p.

研究成果: Article › 査読

Open Access

Activating mutations in EGFR and PI3K promote ATF4 induction for NSCLC cell survival during amino acid deprivation

Takahashi, M., Okamoto, Y., Kato, Y., Shirahama, H., Tsukahara, S., Sugimoto, Y. & Tomida, A., 2023 4月, In: Heliyon. 9, 4, e14799.

研究成果: Article › 査読

Open Access

1 被引用数 (Scopus)

Acute inhibition of AMPA receptors by perampanel reduces amyloid β-protein levels by suppressing β-cleavage of APP in Alzheimer's disease models

Ueda, S., Kuzuya, A., Kawata, M., Okawa, K., Honjo, C., Wada, T., Matsumoto, M., Goto, K., Miyamoto, M., Yonezawa, A., Tanabe, Y., Ikeda, A., Kinoshita, A. & Takahashi, R., 2023 11月, In: FASEB Journal. 37, 11, e23252.

研究成果: Article › 査読

Open Access

Antimicrobial Efficacy Evaluations of Metronidazole against Clostridioides difficile Infection using Fecal Pharmacokinetic and Pharmacodynamic Analyses

Tashiro, S., Taguchi, K., Enoki, Y. & Matsumoto, K., 2023 7月, In: Pharmaceutical research. 40, 7, p. 1799-1806 8 p.

研究成果: Article › 査読

1 被引用数 (Scopus)

A quality management system aiming to ensure regulatory-grade data quality in a glaucoma registry

Wada, S., Tsuda, S., Abe, M., Nakazawa, T. & Urushihara, H., 2023 6月, In: PloS one. 18, 6 June, e0286669.

研究成果: Article › 査読

Open Access

1 被引用数 (Scopus)

Aquaporins contribute to vacuoles formation in Nile grass type II diabetic rats

Aihara, K., Nakazawa, Y., Takeda, S., Hatsusaka, N., Onouchi, T., Hiramatsu, N., Nagata, M., Nagai, N., Funakoshi-Tago, M., Yamamoto, N. & Sasaki, H., 2023 12月, In: Medical Molecular Morphology. 56, 4, p. 274-287 14 p.

研究成果: Article › 査読

Association Between Ambulatory Blood Pressure and Risk of Home Hypertension in a Normotensive Population: The Ohasama Study

Nakayama, S., Satoh, M., Metoki, H., Murakami, T., Tatsumi, Y., Asayama, K., Hara, A., Hirose, T., Tsubota-Utsugi, M., Kikuya, M., Mori, T., Hozawa, A., Imai, Y. & Ohkubo, T., 2023 3月 1, In: American journal of hypertension. 36, 3, p. 151-158 8 p.

研究成果: Article › 査読

1 被引用数 (Scopus)

A validation study for the utility of serum microRNA as a diagnostic and prognostic marker in patients with osteosarcoma

Araki, Y., Asano, N., Yamamoto, N., Hayashi, K., Takeuchi, A., Miwa, S., Igarashi, K., Higuchi, T., Kensaku, A. B. E., Taniguchi, Y., Yonezawa, H., Morinaga, S., Asano, Y., Yoshida, T., Hanayama, R., Matsuzaki, J., Ochiya, T., Kawai, A. & Tsuchiya, H., 2023 6月, In: Oncology Letters. 25, 6, 222.

研究成果: Article › 査読

Open Access

BCL6B Contributes to Ocular Vascular Diseases via Notch Signal Silencing

Tanaka, M., Nakamura, S., Sakaue, T., Yamamoto, T., Maekawa, M., Nishinaka, A., Yasuda, H., Yunoki, K., Sato, Y., Sawa, M., Yoshino, K., Shimazawa, M., Hatano, M., Tokuhisa, T., Higashiyama, S. & Hara, H., 2023 6月 1, In: Arteriosclerosis, Thrombosis, and Vascular Biology. 43, 6, p. 927-942 16 p.

研究成果: Article › 査読

Open Access

Clinical and biomarker factors affecting survival in patients with platinum-sensitive relapsed ovarian cancer receiving olaparib monotherapy: a multicenter retrospective study

Tashiro, R., Kawazoe, H., Mamishin, K., Seto, K., Udagawa, R., Saito, Y., Hashimoto, H., Shimoi, T., Yonemori, K., Yonemura, M., Terakado, H., Nishimura, T., Kawasaki, T., Furukawa, T. & Nakamura, T., 2023 12月, In: Scientific reports. 13, 1, 11962.

研究成果: Article › 査読

Open Access

Comparison of Regulations for Arsenic and Heavy Metals in Herbal Medicines Using Pharmacopoeias of Nine Counties/Regions

Inada, I., Kiuchi, F. & Urushihara, H., 2023 9月, In: Therapeutic Innovation and Regulatory Science. 57, 5, p. 963-974 12 p.

研究成果: Article › 査読

Open Access

Comparison of the efficacy and safety of standard- and high-dose daptomycin: A systematic review and meta-analysis

Samura, M., Takada, K., Hirose, N., Kurata, T., Nagumo, F., Uchida, M., Inoue, J., Tanikawa, K., Enoki, Y., Taguchi, K., Matsumoto, K., Ueda, T., Fujimura, S., Mikamo, H., Takesue, Y. & Mitsutake, K., 2023 4月, In: British journal of clinical pharmacology. 89, 4, p. 1291-1303 13 p.

研究成果: Article › 査読

Open Access

Correction: Comparison of Regulations for Arsenic and Heavy Metals in Herbal Medicines Using Pharmacopoeias of Nine Counties/Regions (Therapeutic Innovation & Regulatory Science, (2023), 57, 5, (963-974), 10.1007/s43441-023-00532-2)

Inada, I., Kiuchi, F. & Urushihara, H., 2023 9月, In: Therapeutic Innovation and Regulatory Science. 57, 5, p. 975 1 p.

研究成果: Comment/debate › 査読

Open Access

Corrigendum to “Elucidation of the inhibitory effect of (+)-hopeaphenol on polyinosinicepolycytidylic acid-induced innate immunity activation in human cerebral microvascular endothelial cells” [Journal of Pharmacological Sciences 149 (2022) 147–157, (S134786132200038X), (10.1016/j.jphs.2022.04.011)]

Xu, L., Yu, Z., Uekusa, Y., Kawaguchi, S., Kikuchi, H., Daitoku, K., Minakawa, M., Motomura, S., Furukawa, K. I., Oshima, Y., Seya, K. & Imaizumi, T., 2023 1月, In: Journal of Pharmacological Sciences. 151, 1, p. 63-64 2 p.

研究成果: Comment/debate › 査読

Open Access

Criteria for preclinical models of cholangiocarcinoma: scientific and medical relevance

CCA Model Consortium, 2023 7月, In: Nature Reviews Gastroenterology and Hepatology. 20, 7, p. 462-480 19 p.

研究成果: Article › 査読

Open Access

4 被引用数 (Scopus)

Derivatives of Differentiation-Inducing Factor 1 Differentially Control Chemotaxis and Stalk Cell Differentiation in Dictyostelium discoideum

Kuwayama, H., Kikuchi, H. & Kubohara, Y., 2023 6月, In: Biology. 12, 6, 873.

研究成果: Article › 査読

Open Access

Detection of Vaccine Adverse Events Before Package Insert Revisions Using a Japanese Spontaneous Reporting System

Suzuki, S., Imai, S., Mitsuboshi, S., Kizaki, H., Hashiguchi, M. & Hori, S., 2023 8月, In: Journal of Clinical Pharmacology. 63, 8, p. 903-908 6 p.

研究成果: Article › 査読

Open Access

2 被引用数 (Scopus)

Determination of single-molecule transport activity of OATP2B1 by measuring the number of transporter molecules using electrophysiological approach

Yajima, K., Akiyoshi, T., Sakamoto, K., Suzuki, Y., Oka, T., Imaoka, A., Yamamura, H., Kurokawa, J. & Ohtani, H., 2023 11月, In: Journal of Pharmacological Sciences. 153, 3, p. 153-160 8 p.

研究成果: Article › 査読

Open Access

Development of a fluorescent-labeled trapping reagent to evaluate the risk posed by acyl-CoA conjugates

Shibazaki, C., Mashino, T. & Ohe, T., 2023 10月, In: Drug Metabolism And Pharmacokinetics. 52, 100509.

研究成果: Article › 査読

Development of an optimized and practical pharmacokinetics/pharmacodynamics analysis method for aztreonam/nacubactam against carbapenemase-producing K. pneumoniae

Igarashi, Y., Takemura, W., Liu, X., Kojima, N., Morita, T., Chuang, V. T. G., Enoki, Y., Taguchi, K. & Matsumoto, K., 2023 4月 1, In: Journal of Antimicrobial Chemotherapy. 78, 4, p. 991-999 9 p.

研究成果: Article › 査読

Open Access

1 被引用数 (Scopus)

Development of a novel drug information provision system for Kampo medicine using natural language processing technology

Maeda-Minami, A., Yoshino, T., Yumoto, T., Sato, K., Sagara, A., Inaba, K., Kominato, H., Kimura, T., Takishita, T., Watanabe, G., Nakamura, T., Mano, Y., Horiba, Y., Watanabe, K. & Kamei, J., 2023 12月, In: BMC Medical Informatics and Decision Making. 23, 1, 119.

研究成果: Article › 査読

Open Access

Differences in Pharmacokinetic/Pharmacodynamic Parameters of Tedizolid Against VRE and MRSA

Liu, X., Tashiro, S., Igarashi, Y., Takemura, W., Kojima, N., Morita, T., Hayashi, M., Enoki, Y., Taguchi, K. & Matsumoto, K., 2023 1月, In: Pharmaceutical research. 40, 1, p. 187-196 10 p.

研究成果: Article › 査読

6 被引用数 (Scopus)

Dysautonomia associated with immune checkpoint inhibitors

Tezuka, T., Okuzumi, S., Nakashima, C., Ide, T., Imai, S., Mitsuboshi, S., Kuwahara, Y., Takizawa, T., Seki, M., Minematsu, N., Aragane, N., Nakahara, J., Hori, S., Nakane, S. & Suzuki, S., 2023 7月, In: Journal of Neurology. 270, 7, p. 3413-3423 11 p.

研究成果: Article › 査読

1 被引用数 (Scopus)

Dysregulated ceramide metabolism in mouse progressive dermatitis resulting from constitutive activation of Jak1

Iino, Y., Naganuma, T. & Arita, M., 2023 2月, In: Journal of lipid research. 64, 2, 100329.

研究成果: Article › 査読

Open Access

1 被引用数 (Scopus)

Enzymatically-epoxidized docosahexaenoic acid, 19,20-EpDPE, suppresses hepatic crown-like structure formation and nonalcoholic steatohepatitis fibrosis through GPR120

Aoki, H., Isobe, Y., Yoshida, M., Kang, J. X., Maekawa, M. & Arita, M., 2023 3月, In: Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 1868, 3, 159275.

研究成果: Article › 査読

Open Access

2 被引用数 (Scopus)

Essential lipid autacoids rewire mitochondrial energy efficiency in metabolic dysfunction-associated fatty liver disease

López-Vicario, C., Sebastián, D., Casulleras, M., Duran-Güell, M., Flores-Costa, R., Aguilar, F., Lozano, J. J., Zhang, I. W., Titos, E., Kang, J. X., Zorzano, A., Arita, M. & Clària, J., 2023 4月, In: Hepatology. 77, 4, p. 1303-1318 16 p.

研究成果: Article › 査読

Open Access

9 被引用数 (Scopus)

Evidence for in vitro extensive proliferation of adult hepatocytes and biliary epithelial cells

Katsuda, T., Sussman, J., Li, J., Merrell, A. J., Vostrejs, W., Secreto, A., Matsuzaki, J., Ochiya, T. & Stanger, B. Z., 2023 7月 11, In: Stem cell reports. 18, 7, p. 1436-1450 15 p.

研究成果: Article › 査読

Open Access

Exploring Factors Affecting the Occurrence of Hypersensitivity Reactions Induced by Nonionic Iodine Contrast Media

Chatani, R., Kondo, S., Kamimura, T., Suzuki, S., Komatsubara, E., Hayashi, S., Hashiguchi, M., Kizaki, H., Imai, S. & Hori, S., 2023 9月, In: Journal of Clinical Pharmacology. 63, 9, p. 1002-1008 7 p.

研究成果: Article › 査読

Open Access

Fecal pharmacokinetics/pharmacodynamics characteristics of fidaxomicin and vancomycin against Clostridioides difficile infection elucidated by in vivo feces-based infectious evaluation models

Tashiro, S., Taguchi, K., Enoki, Y. & Matsumoto, K., 2023 5月, In: Clinical Microbiology and Infection. 29, 5, p. 616-622 7 p.

研究成果: Article › 査読

2 被引用数 (Scopus)

Fullerene derivatives as inhibitors of the SARS-CoV-2 main protease

Katagishi, D., Yasuda, D., Takahashi, K., Nakamura, S., Mashino, T. & Ohe, T., 2023 1月 15, In: Bioorganic and Medicinal Chemistry Letters. 80, 129121.

研究成果: Article › 査読

Open Access

1 被引用数 (Scopus)

Gas6 ameliorates intestinal mucosal immunosenescence to prevent the translocation of a gut pathobiont, Klebsiella pneumoniae, to the liver

Tsugawa, H., Ohki, T., Tsubaki, S., Tanaka, R., Matsuzaki, J., Suzuki, H. & Hozumi, K., 2023 6月, In: PLoS Pathogens. 19, 6, e1011139.

研究成果: Article › 査読

Open Access

GTN057, a komaroviquinone derivative, induced myeloma cells' death in vivo and inhibited c-MET tyrosine kinase

Okayama, M., Fujimori, K., Sato, M., Samata, K., Kurita, K., Sugiyama, H., Suto, Y., Iwasaki, G., Yamada, T., Kiuchi, F., Ichikawa, D., Matsushita, M., Hirao, M., Kunieda, H., Yamazaki, K. & Hattori, Y., 2023 4月, In: Cancer medicine. 12, 8, p. 9749-9759 11 p.

研究成果: Article › 査読

Open Access

GTS-21 Enhances Regulatory T Cell Development from T Cell Receptor-Activated Human CD4⁺ T Cells Exhibiting Varied Levels of CHRNA7 and CHRFAM7A Expression

Mashimo, M., Fujii, T., Ono, S., Moriwaki, Y., Misawa, H., Azami, T., Kasahara, T. & Kawashima, K., 2023 8月, In: International journal of molecular sciences. 24, 15, 12257.

研究成果: Article › 査読

Open Access

Gut microbiota-derived lipid metabolites facilitate regulatory T cell differentiation

Shiratori, H., Oguchi, H., Isobe, Y., Han, K. H., Sen, A., Yakebe, K., Takahashi, D., Fukushima, M., Arita, M. & Hase, K., 2023 12月, In: Scientific reports. 13, 1, 8903.

研究成果: Article › 査読

Open Access

Hesperetin treatment attenuates glycation of lens proteins and advanced-glycation end products generation

Doki, Y., Nakazawa, Y., Morishita, N., Endo, S., Nagai, N., Yamamoto, N., Tamura, H. & Funakoshi-Tago, M., 2023 5月, In: Molecular Medicine Reports. 27, 5, 103.

研究成果: Article › 査読

Open Access

Identification of DDX5 as an indispensable activator of the glucocorticoid receptor in adipocyte differentiation

Hokimoto, S., Funakoshi-Tago, M. & Tago, K., 2023 2月, In: FEBS Journal. 290, 4, p. 988-1007 20 p.

研究成果: Article › 査読

1 被引用数 (Scopus)

Identifying high-grade serous ovarian carcinoma- specific extracellular vesicles by polyketone-coated nanowires

Yokoi, A., Ukai, M., Yasui, T., Inokuma, Y., Hyeon-Deuk, K., Matsuzaki, J., Yoshida, K., Kitagawa, M., Chattrairat, K., Iida, M., Shimada, T., Manabe, Y., Chang, I. Y., Asano-Inami, E., Koya, Y., Nawa, A., Nakamura, K., Kiyono, T., Kato, T., Hirakawa, A., & 6 othersYoshioka, Y., Ochiya, T., Hasegawa, T., Baba, Y., Yamamoto, Y. & Kajiyama, H., 2023 7月 7, In: Science Advances. 9, 27, ade6958.

研究成果: Article › 査読

Open Access

Increased risk of Lambert-Eaton myasthenic syndrome (LEMS) in small-cell lung cancer patients treated with immune checkpoint inhibitor

Imai, S., Mitsuboshi, S., Hori, S. & Suzuki, S., 2023 2月, In: European Journal of Cancer. 180, p. 1-3 3 p.

研究成果: Letter › 査読

3 被引用数 (Scopus)

Influence of Voiced and Semi-voiced Sounds on the Subjective Similarity of Different Drug Names: A Cognitive Psychological Experiment

Yoshikawa, K., Kizaki, H., Imai, S. & Hori, S., 2023 11月, In: Biological and Pharmaceutical Bulletin. 46, 11, p. 1630-1634 5 p.

研究成果: Article › 査読

Open Access

Ingenol mebutate inhibits the growth of pancreatic cancer cells in vitro via STING with an efficacy comparable to that of clinically used anticancer agents

Kikuyama, F., Suzuki, S., Jibiki, A., Yokoyama, Y., Kawazoe, H., Kitanaka, S. & Nakamura, T., 2023 3月, In: Journal of Natural Medicines. 77, 2, p. 343-351 9 p.

研究成果: Article › 査読

Inhibition of the dorsomedial striatal direct pathway is essential for the execution of action sequences

Kono, A., Shikano, Y., Tanaka, K. F., Yamaura, K. & Tsutsui-Kimura, I., 2023 9月, In: Neuropsychopharmacology Reports. 43, 3, p. 414-424 11 p.

研究成果: Article › 査読

Open Access

Investigation of Prescription Status and Exploration of Risk Factors Related to Denosumab-Induced Hypocalcemia in Combination Therapy with 1α,25-Dihydroxy-vitamin D3

Ikegami, K., Saito, M., Imai, S., Kizaki, H., Yasumuro, O., Funakoshi, R. & Hori, S., 2023, In: Biological and Pharmaceutical Bulletin. 46, 1, p. 95-101 7 p.

研究成果: Article › 査読

Open Access

In vivo Pharmacokinetic/Pharmacodynamic Analysis of the Efficacy of the Cefepime/Nacubactam Combination Against β-Lactamase-Producing Enterobacterales based on the Instantaneous MIC Concept

Igarashi, Y., Takemura, W., Liu, X., Kojima, N., Morita, T., Chuang, V. T. G., Enoki, Y., Taguchi, K. & Matsumoto, K., 2023 10月, In: Pharmaceutical research. 40, 10, p. 2423-2431 9 p.

研究成果: Article › 査読

In vivo Pharmacokinetics/Pharmacodynamics Profiles for Appropriate Doses of Cefditoren pivoxil against S. pneumoniae in Murine Lung-Infection Model

Igarashi, Y., Kojima, N., Takemura, W., Liu, X., Morita, T., Mizukami, Y., Enoki, Y., Taguchi, K., Yokoyama, Y., Nakamura, T. & Matsumoto, K., 2023 7月, In: Pharmaceutical research. 40, 7, p. 1789-1797 9 p.

研究成果: Article › 査読

Kaposi's sarcoma–associated herpesvirus replication and transcription activator protein activates CD274/PD-L1 gene promoter

Miyazawa, M., Yamamoto, Y., Katayama, K., Sugimoto, Y. & Noguchi, K., 2023 4月, In: Cancer science. 114, 4, p. 1718-1728 11 p.

研究成果: Article › 査読

Open Access

L-type Amino Acid Transporter 1 (SLC7A5)-Mediated Transport of Pregabalin at the Rat Blood-Spinal Cord Barrier and its Sensitivity to Plasma Branched-Chain Amino Acids

Akashi, T., Noguchi, S., Takahashi, Y., Nishimura, T. & Tomi, M., 2023 4月, In: Journal of Pharmaceutical Sciences. 112, 4, p. 1137-1144 8 p.

研究成果: Article › 査読

Methemoglobin-albumin clusters for cyanide detoxification

Suzuki, Y., Taguchi, K., Okamoto, W., Enoki, Y., Komatsu, T. & Matsumoto, K., 2023 5月 1, In: Toxicology and Applied Pharmacology. 466, 116472.

研究成果: Article › 査読

Open Access

1 被引用数 (Scopus)

Mitochondria directly sense osmotic stress to trigger rapid metabolic remodeling via regulation of pyruvate dehydrogenase phosphorylation

Ikizawa, T., Ikeda, K., Arita, M., Kitajima, S., Soga, T., Ichijo, H. & Naguro, I., 2023 2月, In: Journal of Biological Chemistry. 299, 2, 102837.

研究成果: Article › 査読

Open Access

Model-informed precision dosing of teicoplanin for the rapid achievement of the target area under the concentration-time curve: A simulation study

Oda, K., Yamada, T., Matsumoto, K., Hanai, Y., Ueda, T., Samura, M., Shigemi, A., Jono, H., Saito, H. & Kimura, T., 2023 4月, In: Clinical and Translational Science. 16, 4, p. 704-713 10 p.

研究成果: Article › 査読

Open Access

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