薬科学科

2023

A brief introduction to highly symmetric N-heteroarene-based macrocycles

Xu, W. & Kumagai, N., 2023 7月 17, In: Tetrahedron. 141, 133512.

研究成果: Review article › 査読

Applying deep learning to iterative screening of medium-sized molecules for protein-protein interaction-targeted drug discovery

Shimizu, Y., Yonezawa, T., Bao, Y., Sakamoto, J., Yokogawa, M., Furuya, T., Osawa, M. & Ikeda, K., 2023 5月 11, In: Chemical Communications. 59, 44, p. 6722-6725 4 p.

研究成果: Article › 査読

Open Access

Azo-tagged C4N4 fluorophores: unusual overcrowded structures and their application to fluorescent imaging

Kohei, M., Takizawa, N., Tsutsumi, R., Xu, W. & Kumagai, N., 2023 1月 30, In: Organic and Biomolecular Chemistry. 21, 14, p. 2889-2893 5 p.

研究成果: Article › 査読

1 被引用数 (Scopus)

Chemical approaches to discover selective inhibitors of sulfurtransferases and transsulfuration enzymes

Sasaki, E. & Hanaoka, K., 2023 1月 1, Sulfurtransferases: Essential Enzymes for Life. Elsevier, p. 145-164 20 p.

研究成果: Chapter

Chemoselective Catalytic Dehydrogenation of Benzylic Amines Driven by the TEtraQuinoline/FeCl₂ Complex

Nishiwaki, M., Xu, W. & Kumagai, N., 2023 9月, In: Asian Journal of Organic Chemistry. 12, 9, e202300261.

研究成果: Article › 査読

Copper-Catalyzed Stereoselective Borylation and Palladium-Catalyzed Stereospecific Cross-Coupling to Give Aryl C-Glycosides

Kurahayashi, K., Hanaya, K., Sugai, T., Hirai, G. & Higashibayashi, S., 2023 1月 27, In: Chemistry - A European Journal. 29, 6, e202203376.

研究成果: Article › 査読

2 被引用数 (Scopus)

Development of pathway-oriented screening to identify compounds to control 2-methylglyoxal metabolism in tumor cells

Yanagi, K., Komatsu, T., Fujikawa, Y., Kojima, H., Okabe, T., Nagano, T., Ueno, T., Hanaoka, K. & Urano, Y., 2023 12月, In: Communications Chemistry. 6, 1, 68.

研究成果: Article › 査読

Open Access

Dietary iodine attenuates allergic rhinitis by inducing ferroptosis in activated B cells

Nakamura, Y., Fuse, Y., Komiyama, S., Nagatake, T., Kunisawa, J. & Hase, K., 2023 12月, In: Scientific reports. 13, 1, 5398.

研究成果: Article › 査読

Open Access

DLiP-PPI library: An integrated chemical database of small-to-medium-sized molecules targeting protein–protein interactions

Ikeda, K., Maezawa, Y., Yonezawa, T., Shimizu, Y., Tashiro, T., Kanai, S., Sugaya, N., Masuda, Y., Inoue, N., Niimi, T., Masuya, K., Mizuguchi, K., Furuya, T. & Osawa, M., 2023 1月 9, In: Frontiers in Chemistry. 10, 1090643.

研究成果: Article › 査読

Open Access

3 被引用数 (Scopus)

Dysfunction of Foxp3⁺ Regulatory T Cells Induces Dysbiosis of Gut Microbiota via Aberrant Binding of Immunoglobulins to Microbes in the Intestinal Lumen

Koshida, K., Ito, M., Yakabe, K., Takahashi, Y., Tai, Y., Akasako, R., Kimizuka, T., Takano, S., Sakamoto, N., Haniuda, K., Ogawa, S., Kimura, S., Kim, Y. G., Hase, K. & Harada, Y., 2023 5月, In: International journal of molecular sciences. 24, 10, 8549.

研究成果: Article › 査読

Open Access

1 被引用数 (Scopus)

Engineered Human Muscle Tissue from Multilayered Aligned Myofiber Sheets for Studies of Muscle Physiology and Predicting Drug Response

Takahashi, H., Wakayama, H., Nagase, K. & Shimizu, T., 2023 2月 17, In: Small Methods. 7, 2, 2200849.

研究成果: Article › 査読

2 被引用数 (Scopus)

Ethylene glycol-based thermoresponsive block copolymer brushes with cell-affinity peptides for thermally controlled interaction with target cells

Nagase, K. & Shimane, R., 2023 9月, In: Materials and Design. 233, 112234.

研究成果: Article › 査読

Open Access

Expeditious Access to the B₃NO₂ Heterocycle Enabling Modular Derivatization

Tsutsumi, R., Kashiwagi, N. & Kumagai, N., 2023 5月 5, In: Journal of Organic Chemistry. 88, 9, p. 6247-6251 5 p.

研究成果: Article › 査読

GTS-21 Enhances Regulatory T Cell Development from T Cell Receptor-Activated Human CD4⁺ T Cells Exhibiting Varied Levels of CHRNA7 and CHRFAM7A Expression

Mashimo, M., Fujii, T., Ono, S., Moriwaki, Y., Misawa, H., Azami, T., Kasahara, T. & Kawashima, K., 2023 8月, In: International journal of molecular sciences. 24, 15, 12257.

研究成果: Article › 査読

Open Access

Gut microbiota-derived lipid metabolites facilitate regulatory T cell differentiation

Shiratori, H., Oguchi, H., Isobe, Y., Han, K. H., Sen, A., Yakebe, K., Takahashi, D., Fukushima, M., Arita, M. & Hase, K., 2023 12月, In: Scientific reports. 13, 1, 8903.

研究成果: Article › 査読

Open Access

Hydration and dehydration behaviors of poly(N-isopropylacrylamide)-grafted silica beads

Nagase, K., Matsuda, J., Takeuchi, A. & Ikemoto, Y., 2023 8月, In: Surfaces and Interfaces. 40, 103058.

研究成果: Article › 査読

Inversion of Diaza[5]Helicenes Through an N−N Bond Breaking Pathway

Kobayashi, T., Ishiwari, F., Fukushima, T., Nojima, Y., Hasegawa, M., Mazaki, Y., Hanaya, K., Sugai, T. & Higashibayashi, S., 2023 8月 1, In: Chemistry - A European Journal. 29, 43, e202301466.

研究成果: Article › 査読

Open Access

Less Is More: N(BOH)₂ Configuration Exhibits Higher Reactivity than the B₃NO₂ Heterocycle in Catalytic Dehydrative Amide Formation

Opie, C. R., Noda, H., Shibasaki, M. & Kumagai, N., 2023 2月 3, In: Organic Letters. 25, 4, p. 694-697 4 p.

研究成果: Article › 査読

6 被引用数 (Scopus)

Medium-chain fatty acids suppress lipotoxicity-induced hepatic fibrosis via the immunomodulating receptor GPR84

Ohue-Kitano, R., Nonaka, H., Nishida, A., Masujima, Y., Takahashi, D., Ikeda, T., Uwamizu, A., Tanaka, M., Kohjima, M., Igarashi, M., Katoh, H., Tanaka, T., Inoue, A., Suganami, T., Hase, K., Ogawa, Y., Aoki, J. & Kimura, I., 2023 1月 24, In: JCI Insight. 8, 2, e165469.

研究成果: Article › 査読

Open Access

2 被引用数 (Scopus)

Oxa-TriQuinoline: A New Entry to Aza-Oxa-Crown Architectures**

Kobayashi, T. & Kumagai, N., 2023 8月 7, In: Angewandte Chemie - International Edition. 62, 32, e202307896.

研究成果: Article › 査読

Open Access

1 被引用数 (Scopus)

Protective effect of the tunneling nanotube-TNFAIP2/M-sec system on podocyte autophagy in diabetic nephropathy

Barutta, F., Bellini, S., Kimura, S., Hase, K., Corbetta, B., Corbelli, A., Fiordaliso, F., Bruno, S., Biancone, L., Barreca, A., Papotti, M. G., Hirsh, E., Martini, M., Gambino, R., Durazzo, M., Ohno, H. & Gruden, G., 2023, In: Autophagy. 19, 2, p. 505-524 20 p.

研究成果: Article › 査読

Open Access

12 被引用数 (Scopus)

Real-time in situ X-ray micro-computed tomography study of the effect of impurities on the crystallization of amorphous nifedipine

Amano, Y., Misawa, T., Miyazaki, T., Ando, D., Koide, T., Izutsu, K. I., Kanazawa, H., Hanaoka, K. & Yamamoto, E., 2023 3月 20, In: Journal of Pharmaceutical and Biomedical Analysis. 226, 115248.

研究成果: Article › 査読

1 被引用数 (Scopus)

Safe and efficient oral allergy immunotherapy using one-pot-prepared mannan-coated allergen nanoparticles

Li, S., Toriumi, H., Takahashi, D., Kamasaki, T., Fujioka, Y., Nagatoishi, S., Li, J., Liu, Y., Hosokawa, T., Tsumoto, K., Ohba, Y., Katayama, Y., Murakami, D., Hase, K. & Mori, T., 2023 12月, In: Biomaterials. 303, 122381.

研究成果: Article › 査読

Selective modification of tryptophan in polypeptides via C-N coupling with azoles using in situ-generated iodine-based oxidants in aqueous media

Watanabe, S., Wada, Y., Kawano, M., Higashibayashi, S., Sugai, T. & Hanaya, K., 2023 10月 16, In: Chemical Communications. 59, 87, p. 13026-13029 4 p.

研究成果: Article › 査読

Synthesis and luminescence properties of substituted benzils

Yasui, M., Fujihara, T., Ohtsu, H., Wada, Y., Shimada, T., Zhu, Y., Kawano, M., Hanaya, K., Sugai, T. & Higashibayashi, S., 2023 12月, In: Communications Chemistry. 6, 1, 245.

研究成果: Article › 査読

Open Access

TDP-43 N-terminal domain dimerisation or spatial separation by RNA binding decreases its propensity to aggregate

Miura, M., Sakaue, F., Matsuno, H., Morita, K., Yoshida, A., Hara, R. I., Nishimura, R., Nishida, Y., Yokogawa, M., Osawa, M. & Yokota, T., 2023 6月, In: FEBS Letters. 597, 12, p. 1667-1676 10 p.

研究成果: Article › 査読

TEtraQuinolines: A Missing Link in the Family of Porphyrinoid Macrocycles

Xu, W., Nagata, Y. & Kumagai, N., 2023 2月 1, In: Journal of the American Chemical Society. 145, 4, p. 2609-2618 10 p.

研究成果: Article › 査読

6 被引用数 (Scopus)

Thermoresponsive bio-affinity interfaces for temperature-modulated selective capture and release of targeted exosomes

Nagase, K., Yamazaki, K., Maekawa, Y. & Kanazawa, H., 2023 2月, In: Materials Today Bio. 18, 100521.

研究成果: Article › 査読

Open Access

3 被引用数 (Scopus)

Thermoresponsive mixed polymer brush to effectively control the adhesion and separation of stem cells by altering temperature

Nagase, K., Wakayama, H., Matsuda, J., Kojima, N. & Kanazawa, H., 2023 6月, In: Materials Today Bio. 20, 100627.

研究成果: Article › 査読

Open Access

3 被引用数 (Scopus)

Transition-Metal-Free β-Selective C-Glycosylation of β-Glycosyl Boronates via Stereoretentive 1,2-Migration

Yasutomi, H., Takeda, D., Yoritate, M., Higashibayashi, S., Sugai, T. & Hirai, G., 2023 3月 1, In: Synlett. 34, 4, p. 347-352 6 p.

研究成果: Article › 査読

1 被引用数 (Scopus)

Unified short syntheses of oxygenated tricyclic aromatic diterpenes by radical cyclization with a photoredox catalyst

Hashimoto, R., Hanaya, K., Sugai, T. & Higashibayashi, S., 2023 12月, In: Communications Chemistry. 6, 1, 169.

研究成果: Article › 査読

Open Access

2022

1,2-Rearrangement from o-Quinols to Multisubstituted Catechols via Retro Diels-Alder Reaction of o-Quinol Dimers

Hashimoto, R., Hanaya, K., Sugai, T. & Higashibayashi, S., 2022, In: Bulletin of the Chemical Society of Japan. 95, 4, p. 663-672 10 p.

研究成果: Article › 査読

2 被引用数 (Scopus)

A bis-pyridinium fullerene derivative induces apoptosis through the generation of ROS in BCR-ABL-positive leukemia cells

Sumi, K., Tago, K., Nakazawa, Y., Takahashi, K., Ohe, T., Mashino, T. & Funakoshi-Tago, M., 2022 2月 5, In: European journal of pharmacology. 916, 174714.

研究成果: Article › 査読

2 被引用数 (Scopus)

A double-helical S,C-bridged tetraphenyl-para-phenylenediamine and its persistent radical cation

Harada, K., Hasegawa, C., Matsumoto, T., Sugishita, H., Kitamura, C., Higashibayashi, S., Hasegawa, M., Suzuki, S. & Kato, S. I., 2022 12月 31, In: Chemical Communications. 59, 10, p. 1301-1304 4 p.

研究成果: Article › 査読

A Novel HDAC1-Selective Inhibitor Attenuates Autoimmune Arthritis by Inhibiting Inflammatory Cytokine Production

Zhe, W., Hoshina, N., Itoh, Y., Tojo, T., Suzuki, T., Hase, K. & Takahashi, D., 2022 9月, In: Biological and Pharmaceutical Bulletin. 45, 9, p. 1364-1372 9 p.

研究成果: Article › 査読

Open Access

1 被引用数 (Scopus)

A thermoresponsive cationic block copolymer brush-grafted silica bead interface for temperature-modulated separation of adipose-derived stem cells

Nagase, K., Okada, A., Matsuda, J., Ichikawa, D., Hattori, Y. & Kanazawa, H., 2022 12月, In: Colloids and Surfaces B: Biointerfaces. 220, 112928.

研究成果: Article › 査読

4 被引用数 (Scopus)

Chromatography columns packed with thermoresponsive-cationic-polymer-modified beads for therapeutic drug monitoring

Nagase, K., Takagi, H., Nakada, H., Ishikawa, H., Nagata, Y., Aomori, T. & Kanazawa, H., 2022 12月, In: Scientific reports. 12, 1, 12847.

研究成果: Article › 査読

Open Access

2 被引用数 (Scopus)

Cooperative action of gut-microbiota-accessible carbohydrates improves host metabolic function

Tomioka, S., Seki, N., Sugiura, Y., Akiyama, M., Uchiyama, J., Yamaguchi, G., Yakabe, K., Ejima, R., Hattori, K., Kimizuka, T., Fujimura, Y., Sato, H., Gondo, M., Ozaki, S., Honme, Y., Suematsu, M., Kimura, I., Inohara, N., Núñez, G., Hase, K., & 1 othersKim, Y. G., 2022 7月 19, In: Cell Reports. 40, 3, 111087.

研究成果: Article › 査読

Open Access

11 被引用数 (Scopus)

Development of p62-Keap1 protein–protein interaction inhibitors as doxorubicin-sensitizers against non-small cell lung cancer

Yasuda, D., Yoshida, I., Imamura, R., Katagishi, D., Takahashi, K., Kojima, H., Okabe, T., Ichimura, Y., Komatsu, M., Mashino, T. & Ohe, T., 2022 1月, In: Results in Chemistry. 4, 100609.

研究成果: Article › 査読

Open Access

Dietary-protein sources modulate host susceptibility to Clostridioides difficile infection through the gut microbiota

Yakabe, K., Higashi, S., Akiyama, M., Mori, H., Murakami, T., Toyoda, A., Sugiyama, Y., Kishino, S., Okano, K., Hirayama, A., Gotoh, A., Li, S., Mori, T., Katayama, T., Ogawa, J., Fukuda, S., Hase, K. & Kim, Y. G., 2022 9月 13, In: Cell Reports. 40, 11, 111332.

研究成果: Article › 査読

Open Access

5 被引用数 (Scopus)

_D-Tryptophan suppresses enteric pathogen and pathobionts and prevents colitis by modulating microbial tryptophan metabolism

Seki, N., Kimizuka, T., Gondo, M., Yamaguchi, G., Sugiura, Y., Akiyama, M., Yakabe, K., Uchiyama, J., Higashi, S., Haneda, T., Suematsu, M., Hase, K. & Kim, Y. G., 2022 8月 19, In: iScience. 25, 8, 104838.

研究成果: Article › 査読

Open Access

3 被引用数 (Scopus)

Erratum: Structural basis for the oligomerization-mediated regulation of NLRP3 inflammasome activation (Proceedings of the National Academy of Sciences of the United States of America 119 (e2121353119) DOI: 10.1073/pnas.2121353119)

Ohto, U., Kamitsukasa, Y., Ishida, H., Zhang, Z., Murakami, K., Hirama, C., Maekawa, S. & Shimizu, T., 2022 5月 3, In: Proceedings of the National Academy of Sciences of the United States of America. 119, 18, e2204762119.

研究成果: Comment/debate › 査読

Open Access

1 被引用数 (Scopus)

General Design Strategy to Precisely Control the Emission of Fluorophores via a Twisted Intramolecular Charge Transfer (TICT) Process

Hanaoka, K., Iwaki, S., Yagi, K., Myochin, T., Ikeno, T., Ohno, H., Sasaki, E., Komatsu, T., Ueno, T., Uchigashima, M., Mikuni, T., Tainaka, K., Tahara, S., Takeuchi, S., Tahara, T., Uchiyama, M., Nagano, T. & Urano, Y., 2022 11月 2, In: Journal of the American Chemical Society. 144, 43, p. 19778-19790 13 p.

研究成果: Article › 査読

18 被引用数 (Scopus)

Glia maturation factor-γis involved in S1P-induced marginal zone B-cell chemotaxis and optimal IgM production to type II T-independent antigen

Li, Y., Tang, Y., Liu, J., Meng, X., Wang, Y., Min, Q., Hong, R., Tsubata, T., Hase, K. & Wang, J. Y., 2022 1月 1, In: International immunology. 34, 1, p. 35-43 9 p.

研究成果: Article › 査読

2 被引用数 (Scopus)

Gut microbiota reinforce host antioxidant capacity via the generation of reactive sulfur species

Uchiyama, J., Akiyama, M., Hase, K., Kumagai, Y. & Kim, Y. G., 2022 3月 8, In: Cell Reports. 38, 10, 110479.

研究成果: Article › 査読

Open Access

30 被引用数 (Scopus)

Identification of Wnt7a^K190A mutant and its restorative action on blood-brain barrier

Yamagishi, H., Yonezu, Y., Misawa, H. & Muramatsu, R., 2022, In: Folia Pharmacologica Japonica. 157, 6, p. 474 1 p.

研究成果: Article › 査読

Inhibition of RANKL and Sema4D improves residual ridge resorption in mice

Hisamoto, M., Kimura, S., Iwata, K., Iwanaga, T. & Yokoyama, A., 2022 12月, In: Scientific reports. 12, 1, 4094.

研究成果: Article › 査読

Open Access

3 被引用数 (Scopus)

Intramolecular cyclization of m-homoprenylphenols through oxidative nucleophilic aromatic substitution

Deguchi, H., Hanaya, K., Sugai, T. & Higashibayashi, S., 2022 12月 15, In: Chemical Communications. 59, 6, p. 748-751 4 p.

研究成果: Article › 査読

2 被引用数 (Scopus)

Involvement of neuronal and muscular Trk-fused gene (TFG) defects in the development of neurodegenerative diseases

Yamamotoya, T., Hasei, S., Akasaka, Y., Ohata, Y., Nakatsu, Y., Kanna, M., Fujishiro, M., Sakoda, H., Ono, H., Kushiyama, A., Misawa, H. & Asano, T., 2022 12月, In: Scientific reports. 12, 1, 1966.

研究成果: Article › 査読

Open Access

3 被引用数 (Scopus)

Lysophosphatidic acid stimulates pericyte migration via LPA receptor 1

Yonezu, Y., Tanabe, S., Misawa, H. & Muramatsu, R., 2022 8月 27, In: Biochemical and Biophysical Research Communications. 618, p. 61-66 6 p.

研究成果: Article › 査読

Open Access

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