年別の研究成果
年別の研究成果
- 45 件
検索結果
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2024
The Effects of N-Glycosylation on the Expression and Transport Activity of OATP1A2 and OATP2B1
Kataoka, H., Akiyoshi, T., Uchida, Y., Imaoka, A., Terasaki, T. & Ohtani, H., 2024 5月, In: Journal of Pharmaceutical Sciences. 113, 5, p. 1376-1384 9 p.研究成果: Article › 査読
Open Access -
2023
Determination of single-molecule transport activity of OATP2B1 by measuring the number of transporter molecules using electrophysiological approach
Yajima, K., Akiyoshi, T., Sakamoto, K., Suzuki, Y., Oka, T., Imaoka, A., Yamamura, H., Kurokawa, J. & Ohtani, H., 2023 11月, In: Journal of Pharmacological Sciences. 153, 3, p. 153-160 8 p.研究成果: Article › 査読
Open Access1 被引用数 (Scopus) -
Irinotecan-induced gastrointestinal damage alters the expression of peptide transporter 1 and absorption of cephalexin in rats
Imaoka, A., Hattori, T., Akiyoshi, T. & Ohtani, H., 2023 10月, In: Biopharmaceutics and Drug Disposition. 44, 5, p. 372-379 8 p.研究成果: Article › 査読
Open Access -
The Effects of Jabara Juice on the Intestinal Permeation of Fexofenadine
Han, H., Akiyoshi, T., Morita, T., Tsuchitani, T., Nabeta, M., Yajima, K., Imaoka, A. & Ohtani, H., 2023, In: Biological and Pharmaceutical Bulletin. 46, 12, p. 1745-1752 8 p.研究成果: Article › 査読
Open Access2 被引用数 (Scopus) -
The influence of temperature on the metabolic activity of CYP2C9, CYP2C19, and CYP3A4 genetic variants in vitro
Kojima, M., Machida, K., Cho, S., Watanabe, D., Seki, H., Shimoji, M., Imaoka, A., Yamazaki, H., Guengerich, F. P., Nakamura, K., Yamamoto, K., Akiyoshi, T. & Ohtani, H., 2023, In: Xenobiotica. 53, 5, p. 357-365 9 p.研究成果: Article › 査読
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2022
Analysis of inhibition kinetics of three beverage ingredients, bergamottin, dihydroxybergamottin and resveratrol, on CYP2C9 activity
Akiyoshi, T., Uchiyama, M., Inada, R., Imaoka, A. & Ohtani, H., 2022 2月, In: Drug Metabolism And Pharmacokinetics. 42, 100429.研究成果: Article › 査読
Open Access3 被引用数 (Scopus) -
Comparison of the inhibitory properties of the fruit component naringenin and its glycosides against OATP1A2 genetic variants
Araki, N., Morita, T., Akiyoshi, T., Kataoka, H., Yajima, K., Katayama, K., Imaoka, A. & Ohtani, H., 2022 10月, In: Drug Metabolism And Pharmacokinetics. 46, 100464.研究成果: Article › 査読
Open Access4 被引用数 (Scopus) -
Comparison of the transport kinetics of fexofenadine and its pH dependency among OATP1A2 genetic variants
Han, H., Akiyoshi, T., Morita, T., Kataoka, H., Katayama, K., Yajima, K., Imaoka, A. & Ohtani, H., 2022 12月, In: Drug Metabolism And Pharmacokinetics. 47, 100470.研究成果: Article › 査読
1 被引用数 (Scopus) -
Evaluation of hepatic CYP3A enzyme activity using endogenous markers in lung cancer patients treated with cisplatin, dexamethasone, and aprepitant
Hibino, H., Sakiyama, N., Makino, Y., Makihara-Ando, R., Horinouchi, H., Fujiwara, Y., Kanda, S., Goto, Y., Yoshida, T., Okuma, Y., Shinno, Y., Murakami, S., Hashimoto, H., Akiyoshi, T., Imaoka, A., Ohe, Y., Yamaguchi, M. & Ohtani, H., 2022 4月, In: European Journal of Clinical Pharmacology. 78, 4, p. 613-621 9 p.研究成果: Article › 査読
3 被引用数 (Scopus) -
Inhibitory Effects of Cranberry Juice and Its Components on Intestinal OATP1A2 and OATP2B1: Identification of Avicularin as a Novel Inhibitor
Morita, T., Akiyoshi, T., Tsuchitani, T., Kataoka, H., Araki, N., Yajima, K., Katayama, K., Imaoka, A. & Ohtani, H., 2022 3月 16, In: Journal of agricultural and food chemistry. 70, 10, p. 3310-3320 11 p.研究成果: Article › 査読
9 被引用数 (Scopus) -
Mechanistic bottom-up estimation of passive drug absorption from the gastrointestinal tract: Comparison among primary cultured human intestinal cells, Caco-2 cells, artificial membrane, and animal scale-up
Tsuchitani, T., Akiyoshi, T., Imaoka, A. & Ohtani, H., 2022 5月, In: International journal of clinical pharmacology and therapeutics. 60, 5, p. 217-224 8 p.研究成果: Article › 査読
1 被引用数 (Scopus) -
2021
Comparison of the inhibitory effects of azole antifungals on cytochrome P450 3A4 genetic variants
Yamaguchi, Y., Akiyoshi, T., Kawamura, G., Imaoka, A., Miyazaki, M., Guengerich, F. P., Nakamura, K., Yamamoto, K. & Ohtani, H., 2021 6月, In: Drug Metabolism And Pharmacokinetics. 38, 100384.研究成果: Article › 査読
Open Access9 被引用数 (Scopus) -
Digoxin absorption decreased independently of P-gp activity in rats with irinotecan-induced gastrointestinal damage
Tsuchitani, T., Akiyoshi, T., Imaoka, A. & Ohtani, H., 2021 12月, In: Journal of Pharmaceutical Health Care and Sciences. 7, 1, 24.研究成果: Article › 査読
Open Access2 被引用数 (Scopus) -
Dual kinetics of OATP2B1: Inhibitory potency and pH-dependence of OATP2B1 inhibitors
Sato, R., Akiyoshi, T., Morita, T., Katayama, K., Yajima, K., Kataoka, H., Imaoka, A. & Ohtani, H., 2021 12月, In: Drug Metabolism And Pharmacokinetics. 41, 100416.研究成果: Article › 査読
Open Access8 被引用数 (Scopus) -
Estimation of absolute oral bioavailability without performing an intravenous clinical study
Ohtani, H., Iwata, R., Imaoka, A. & Akiyoshi, T., 2021 6月, In: Drug Metabolism And Pharmacokinetics. 38, 100392.研究成果: Article › 査読
Open Access3 被引用数 (Scopus) -
Exacerbation of atrioventricular block associated with concomitant use of amlodipine and aprepitant in a lung cancer patient: A case report
Hibino, H., Makino, Y., Sakiyama, N., Makihara-Ando, R., Hashimoto, H., Akiyoshi, T., Imaoka, A., Fujiwara, Y., Ohe, Y., Yamaguchi, M. & Ohtani, H., 2021 4月, In: International journal of clinical pharmacology and therapeutics. 59, 4, p. 328-332 5 p.研究成果: Article › 査読
3 被引用数 (Scopus) -
Relative contributions of metabolic enzymes to systemic elimination can be estimated from clinical DDI studies: Validation using an in silico approach
Koinuma, K., Tsuchitani, T., Imaoka, A., Akiyoshi, T. & Ohtani, H., 2021 3月, In: International journal of clinical pharmacology and therapeutics. 59, 3, p. 231-238 8 p.研究成果: Article › 査読
2 被引用数 (Scopus) -
Time-dependent inhibition of CYP3A4- mediated midazolam metabolism by macrolide antibiotics in CYP3A4 genetic variants: Comparison with testosterone metabolism
Akiyoshi, T., Naitou, R., Imaoka, A., Miyazaki, M., Guengerich, F. P., Nakamura, K., Yamamoto, K. & Ohtani, H., 2021 12月, In: International journal of clinical pharmacology and therapeutics. 59, 12, p. 745-782 38 p.研究成果: Article › 査読
Open Access -
2020
Citrus Fruit-Derived Flavanone Glycoside Narirutin is a Novel Potent Inhibitor of Organic Anion-Transporting Polypeptides
Morita, T., Akiyoshi, T., Sato, R., Uekusa, Y., Katayama, K., Yajima, K., Imaoka, A., Sugimoto, Y., Kiuchi, F. & Ohtani, H., 2020 12月 2, In: Journal of agricultural and food chemistry. 68, 48, p. 14182-14191 10 p.研究成果: Article › 査読
13 被引用数 (Scopus) -
Correction to: Novel method to estimate the appropriate dosing interval for activated charcoal to avoid interaction with other drugs (European Journal of Clinical Pharmacology, (2020), 76, 11, (1529-1536), 10.1007/s00228-020-02931-y)
Ohtani, H., Nakamura, K., Imaoka, A. & Akiyoshi, T., 2020 11月 1, In: European Journal of Clinical Pharmacology. 76, 11, p. 1537 1 p.研究成果: Comment/debate › 査読
Open Access -
Novel method to estimate the appropriate dosing interval for activated charcoal to avoid interaction with other drugs
Ohtani, H., Nakamura, K., Imaoka, A. & Akiyoshi, T., 2020 11月 1, In: European Journal of Clinical Pharmacology. 76, 11, p. 1529-1536 8 p.研究成果: Article › 査読
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pH-dependent transport kinetics of the human organic anion-transporting polypeptide 1A2
Morita, T., Akiyoshi, T., Sato, R., Katayama, K., Yajima, K., Kataoka, H., Imaoka, A., Sugimoto, Y. & Ohtani, H., 2020 4月, In: Drug Metabolism And Pharmacokinetics. 35, 2, p. 220-227 8 p.研究成果: Article › 査読
16 被引用数 (Scopus) -
Profile of the inhibitory effects of gefitinib in CYP2D6 variants in vitro
Semba, Y., Akiyoshi, T., Hibino, H., Imaoka, A. & Ohtani, H., 2020 10月, In: International journal of clinical pharmacology and therapeutics. 58, 10, p. 539-542 4 p.研究成果: Article › 査読
2 被引用数 (Scopus) -
2019
Effects of food type on the extent of drug-drug interactions between activated charcoal and phenobarbital in rats
Ogata, Y., Imaoka, A., Akiyoshi, T. & Ohtani, H., 2019 1月 1, In: Drug Metabolism And Pharmacokinetics.研究成果: Article › 査読
1 被引用数 (Scopus) -
Inhibitory kinetics of fruit components on CYP2C19 activity
Seki, H., Akiyoshi, T., Imaoka, A. & Ohtani, H., 2019 6月, In: Drug Metabolism And Pharmacokinetics. 34, 3, p. 181-186 6 p.研究成果: Article › 査読
9 被引用数 (Scopus) -
Irinotecan-induced gastrointestinal damage impairs the absorption of dabigatran etexilate
Hattori, T., Imaoka, A., Akiyoshi, T. & Ohtani, H., 2019 11月 1, In: Biopharmaceutics and Drug Disposition. 40, 9, p. 315-324 10 p.研究成果: Article › 査読
8 被引用数 (Scopus) -
The extent of drug-drug interaction between amlodipine and activated charcoal is attenuated by food intake in rats
Imaoka, A., Seki, K., Akiyoshi, T. & Ohtani, H., 2019 2月, In: Drug Metabolism And Pharmacokinetics. 34, 1, p. 108-110 3 p.研究成果: Article › 査読
2 被引用数 (Scopus) -
2017
5-Fluorouracil treatment alters the expression of intestinal transporters in rats
Yotsumoto, K., Akiyoshi, T., Wada, N., Imaoka, A. & Ohtani, H., 2017 12月, In: Biopharmaceutics and Drug Disposition. 38, 9, p. 509-516 8 p.研究成果: Article › 査読
10 被引用数 (Scopus) -
Analysis of the mechanism of prolonged persistence of drug interaction between terbinafine and amitriptyline or nortriptyline
Mikami, A., Hori, S., Ohtani, H. & Sawada, Y., 2017, In: Biological and Pharmaceutical Bulletin. 40, 7, p. 1010-1020 11 p.研究成果: Article › 査読
1 被引用数 (Scopus) -
Development and evaluation of an overseas clinical rotation program for undergraduate pharmacy students in Japan
Ohtani, H., Mitsui, R., Akiyoshi, T., Imaoka, A., Abe, Y., Kanke, M., Nakamura, T., Foster, P. & Mochizuki, M., 2017 5月, In: Currents in Pharmacy Teaching and Learning. 9, 3, p. 452-459 8 p.研究成果: Article › 査読
2 被引用数 (Scopus) -
Development of a new scholastic program for medication counseling practice in preclinical training, constructed for junior students by senior students based on their experiences of on-site practice
Suzuki, S., Aono, I., Imai, N., Kuwabara, A., Kenda, Y., Matsumoto, M., Yoshida, A., Watanabe, A., Takagi, A., Kobayashi, N., Saeki, H., Ohtani, H., Nakamur, T. & Kizud, J., 2017, In: Yakugaku Zasshi. 137, 11, p. 1391-1408 18 p.研究成果: Article › 査読
Open Access -
Inactivation kinetics and residual activity of CYP3A4 after treatment with erythromycin
Ishikawa, Y., Akiyoshi, T., Imaoka, A. & Ohtani, H., 2017 10月, In: Biopharmaceutics and Drug Disposition. 38, 7, p. 420-425 6 p.研究成果: Article › 査読
4 被引用数 (Scopus) -
2016
In silico evaluation of warfarin–bucolome therapy
Ohtani, H., Hakoda, R., Imaoka, A. & Akiyoshi, T., 2016, In: Biopharmaceutics and Drug Disposition. p. 233-242 10 p.研究成果: Article › 査読
3 被引用数 (Scopus) -
2015
Current status of illegal trade in pharmaceutical products on internet auction sites in japan and responses of site administrators to such transactions
Ohtani, H., Imaoka, A. & Akiyoshi, T., 2015 3月 1, In: Yakugaku Zasshi. 135, 3, p. 529-534 6 p.研究成果: Article › 査読
Open Access5 被引用数 (Scopus) -
Variation in the inhibitory potency of terbinafine among genetic variants of CYP2D6
Akiyoshi, T., Ishiuchi, M., Imaoka, A. & Ohtani, H., 2015 8月 1, In: Drug Metabolism And Pharmacokinetics. 30, 4, p. 321-324 4 p.研究成果: Article › 査読
5 被引用数 (Scopus) -
2014
Decrease in ciprofloxacin absorption by polyvalent metal cations is not fully attributable to chelation or adsorption
Imaoka, A., Hattori, M., Akiyoshi, T. & Ohtani, H., 2014, In: Drug Metabolism And Pharmacokinetics. 29, 5, p. 414-418 5 p.研究成果: Article › 査読
5 被引用数 (Scopus) -
Prediction of the extent and variation of grapefruit juice-drug interactions from the pharmacokinetic profile in the absence of grapefruit juice
Kogure, N., Akiyoshi, T., Imaoka, A. & Ohtani, H., 2014 10月 1, In: Biopharmaceutics and Drug Disposition. 35, 7, p. 373-381 9 p.研究成果: Article › 査読
6 被引用数 (Scopus) -
2013
Effect of aromatase inhibitors on bone mineral density in a Japanese breast cancer population
Akiyoshi, T., Shimomura, Y., Masuda, S., Okamoto, Y., Hiura, S., Kato, H., Asayama, T. & Ohtani, H., 2013, In: Drug Metabolism And Pharmacokinetics. 28, 5, p. 446-450 5 p.研究成果: Article › 査読
2 被引用数 (Scopus) -
Mechanism-based inhibition profiles of erythromycin and clarithromycin with cytochrome P450 3A4 genetic variants
Akiyoshi, T., Ito, M., Murase, S., Miyazaki, M., Peter Guengerich, F., Nakamura, K., Yamamoto, K. & Ohtani, H., 2013, In: Drug Metabolism And Pharmacokinetics. 28, 5, p. 411-415 5 p.研究成果: Article › 査読
28 被引用数 (Scopus) -
Pharmacokinetic model incorporating mechanism-based inactivation of CYP2D6 can explain both non-linear kinetics and drug interactions of paroxetine
Mikami, A., Ohtani, H., Hori, S. & Sawada, Y., 2013 5月, In: International journal of clinical pharmacology and therapeutics. 51, 5, p. 374-382 9 p.研究成果: Article › 査読
14 被引用数 (Scopus) -
2011
Bottom-up modeling and simulation of tacrolimus clearance: Prospective investigation of blood cell distribution, sex and CYP3A5 expression as covariates and assessment of study power
Ohtani, H., Barter, Z., Minematsu, T., Makuuchi, M., Sawada, Y. & Rostami-Hodjegan, A., 2011 12月, In: Biopharmaceutics and Drug Disposition. 32, 9, p. 498-506 9 p.研究成果: Article › 査読
6 被引用数 (Scopus) -
Comparison of the inhibitory profiles of itraconazole and cimetidine in cytochrome P450 3A4 genetic variants
Akiyoshi, T., Saito, T., Murase, S., Miyazaki, M., Murayama, N., Yamazaki, H., Guengerich, F. P., Nakamura, K., Yamamoto, K. & Ohtani, H., 2011 4月, In: Drug Metabolism and Disposition. 39, 4, p. 724-728 5 p.研究成果: Article › 査読
Open Access26 被引用数 (Scopus) -
2010
Pharmacokinetic modeling of the dosing interval dependency for the interaction between itraconazole and triazolam
Toi, A., Ohtani, H., Tsujimoto, M. & Sawada, Y., 2010 6月, In: International journal of clinical pharmacology and therapeutics. 48, 6, p. 356-366 11 p.研究成果: Article › 査読
2 被引用数 (Scopus) -
2009
Synergistic action of statins and nitrogen-containing bisphosphonates in the development of rhabdomyolysis in L6 rat skeletal myoblasts
Matzno, S., Nishiguchi, T., Akiyoshi, T., Anami, S., Nakabayashi, T. & Matsuyama, K., 2009 6月, In: Journal of Pharmacy and Pharmacology. 61, 6, p. 781-788 8 p.研究成果: Article › 査読
9 被引用数 (Scopus) -
The potential of vitamin K3 as an anticancer agent against breast cancer that acts via the mitochondria-related apoptotic pathway
Akiyoshi, T., Matzno, S., Sakai, M., Okamura, N. & Matsuyama, K., 2009, In: Cancer Chemotherapy and Pharmacology. 65, 1, p. 143-150 8 p.研究成果: Article › 査読
64 被引用数 (Scopus)